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Podcast title This Week in Microbiology
Website URL http://www.asm.org/twim/
Description This Week in Microbiology is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows 'This Week in Virology' (TWiV) and 'This Week in Parasitism' (TWiP), Racaniello and guests produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.
Updated Thu, 08 Aug 2019 07:05:29 +0000
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Category Science
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Episodes

1. 202: This frass doesn’t stink
http://www.microbe.tv/twim/twi... download (audio/mpeg, 28.31Mb)

Description:

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson and Michael Schmidt

Guest: Julie Wolf

Julie joins the TWiM team to reveal how microbiome and gut anatomy of a wood-feeding beetle promotes lignocellulose deconstruction, and bacteria that degrade PET plastic.

How wood-feeding beetles deconstruct lignocellulose (PNAS) Meet the Microbiologist hosted by Julie Wolf Bacteria that degrade PET plastic (Micr Res Ann) Microbiology resource of the month (ASM) Morgan Vague’s TED talk Pacific garbage patch (Pacific Beach Coal) NOAA marine debris program National Geographic’s Planet or Plastic Campaign  Image credit Letters read on TWiM 202

Subscribe to TWiM (free) on iTunesGoogle PodcastsStitcherAndroidRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a Patron of TWiM!

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



2. 201: Microbiology papers for first year students
http://www.microbe.tv/twim/twi... download (audio/mpeg, 38.50Mb)

Description:

Mark Martin joins Vincent and Michael to present compelling papers suitable for teaching microbiology to undergraduate students.

Become a patron of TWiM.

Links for this episode:

Paradigm shifts, paradigm drifts (pdf) Introducing THOR (mBio) Engineering bacteriophages to treat mycobacterial infection (Nat Med) Biofilms by Colter (Int Microbiol) Life in a world without microbes (PLoS Biol) Reduction of cholera in Bangladeshi villages (PNAS) Placenta goes viral (PLoS Biol) #OMG (jpg) #OMG illustration by Sarah Adkins Microbe-Biologist button (jpg) Microbial Centricity button (jpg) Microbial Eyes button (jpg) Micronauts button (jpg)

Send your microbiology questions and comments to twim@microbe.tv

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.



3. 200: In the company of Elio
http://www.microbe.tv/twim/twi... download (audio/mpeg, 42.25Mb)

Description:

Vincent, Michele, and Michael travel to San Diego to reminisce with Elio about his career, his work in microbiology, and his love for microbes and mushrooms.

VIDEO VERSION AVAILABLE: https://www.youtube.com/watch?v=Menlo1YvPko

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email.Get the entire ASM Podcast Network via our Microbeworld app.

Become a patronof TWiM.

Links for this episode Elio’s profile Elio’s memoirs Elio’s first paper, 1952 (J Bact) In the Company of Mushrooms Small Things Considered TWiM Listener survey

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 



4. 199: PhD Balance
http://www.microbe.tv/twim/twi... download (audio/mpeg, 34.52Mb)

Description:

From ASM Microbe 2019, the Microbials meet up with Susanna L. Harris and Alex Politis to talk about mental health in graduate school and NIH peer review.

Hosts: Vincent Racaniello, Michele Swansonand Michael Schmidt

Guests: Susanna L. Harrisand Alex Politis

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app.

Become a patron of TWiM

Links for this episode PhD Balance Susanna’s video(Vimeo) NIH Center for Scientific Review TWiM Listener survey

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 



5. 198: Unexpectedly pathogenic bacteriophages
http://www.microbe.tv/twim/twi... download (audio/mpeg, 27.71Mb)

Description:

The TWiM team presents an extracellular bacterium associated with Paramecium, and induction of antiviral immunity by a bacteriophage that prevents bacterial clearance.

Subscribe to TWiM (free) on iTunesGoogle PodcastsStitcherAndroidRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Bacteria on the outside of paramecia (ISME) Phage trigger antiviral immunity (Science) Image credit Letters read on TWiM 198

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



6. 197: Intercellular microbial trade
http://www.microbe.tv/twim/twi... download (audio/mpeg, 48.42Mb)

Description:

The Microbials reveal how a chemosynthetic symbiont stores energy for its marine flatworm host, and extraction of nutrients from host cells by E. coli injectisome components.

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Links for this episode:

Take the TWiM listener survey Bacteria store energy for gutless worms (PNAS) Paracatenula on TWiM #21 E. coli extracts nutrients from host cells (Cell) Image credit

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



7. 196: I hear you
http://www.microbe.tv/twim/twi... download (audio/mpeg, 43.76Mb)

Description:

The Microbials discuss how ambrosia beetles utilize ethanol to farm fungi, and how cleaved cochlin protein sequesters bacteria in the inner ear to preserve hearing function.

Links for this episode:

Ambrosia beetles, ethanol, and farmed fungi (PNAS) Cleaved cochlin protects the inner ear (Cell Host Microbe) Importance of flossing (ADA)

Subscribe to TWiM (free) on iTunesGoogle PodcastsStitcherAndroidRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a Patron of TWiM!

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



8. 195: Gingipain in the Alzheimer brain
http://www.microbe.tv/twim/twi... download (audio/mpeg, 34.19Mb)

Description:

Michael and Vincent discuss the finding of immunity to Cas9 protein in humans, and a potential role for an oral bacterium in Alzheimer’s disease.

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email.Get the entire ASM Podcast Network via our Microbeworld app.

Become a patron of TWiM.

Links for this episode Immunity to Cas9 protein in humans (Nat Med) P. gingivalis and Alzheimer’s disease (Science) Clinical trial of COR388 in AD patients (clinicaltrials.gov) TWiM Listener survey

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 



9. 194: Standard imperial procedure
http://www.microbe.tv/twim/twi... download (audio/mpeg, 30.03Mb)

Description:

Vincent RacanielloMichael Schmidt, Michele Swanson and Elio Schaechter

How a bacterium helps dengue virus replicate in the mosquito gut, and minicells as a damage disposal mechanism in E. coli.

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Links:

Please take the TWiM listener survey Bacteria help dengue virus in mosquito gut (Cell Host Micr) Fungus helps dengue virus in mosquito gut (TWiV 479) Minicells for disposal of damaged goods (mSphere) TWiM Listener survey

Subscribe to TWiM (free) on iTunesGoogle PodcastsStitcherAndroidRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a Patron of TWiM!

Send your microbiology questions and comments to twim@microbe.tv



10. 193: Persisters
http://www.microbe.tv/twim/twi... download (audio/mpeg, 27.88Mb)

Description:

The TWiM team explore how Lactobacillus reuteri can rescue social deficits in three mouse models of autism spectrum disorder, and the role of Salmonella persisters in undermining host defenses during antibiotic treatment.

Subscribe to TWiM (free) on iTunesGoogle PodcastsStitcherAndroidRSS, or by email. 

Become a Patron of TWiM!

Please take the TWiM listener surveyBacteria alter behavior in mouse autism models (Neuron) Mice behaving badly (TWiM 131) Salmonella persisters undermine host immune defenses (Science) Persister cells (Ann Rev Microbiol)

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



11. 192: A Qtip for phages
http://www.microbe.tv/twim/twi... download (audio/mpeg, 30.45Mb)

Description:

The TWiM team reveals an extremely low rate of mutation in a 2500 year old, 185 acre fungus in Michigan, and how a host-produced quorum sensing autoinducer controls the phage switch between lysis and lysogeny.

Please take the TWiM listener survey Vote for NJ State Microbe Huge fungus is 2500 years old (Proc Roy Soc B) Humongous fungus (Wikipedia) Host-produced autoinducer controls phage (Cell) These bacteria are bugged (virology blog)

Subscribe to TWiM (free) on iTunesGoogle PodcastsStitcherAndroidRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a Patron of TWiM!

Links for this episode Please take the TWiM listener survey Vote for NJ State Microbe Huge fungus is 2500 years old (Proc Roy Soc B) Humongous fungus (Wikipedia) Host-produced autoinducer controls phage (Cell) These bacteria are bugged (virology blog)L

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



12. 191: By the pulp of their teeth
http://www.microbe.tv/twim/twi... download (audio/mpeg, 28.27Mb)

Description:

The TWiM team reveals the oldest human plague from 4,900 years ago in Sweden, and engineering E. coli to become an endosymbiont in yeast, modeling the evolution of mitochondria.

Hosts: Vincent Racaniello, Elio Schaechter,  Michael Schmidt,  and Michele Swanson

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app.

Become a patron of TWiM.

Links for this episode Oldest human plague from 4,900 years ago (PNAS) Engineering yeast endosymbionts (PNAS) Letters read on TWiM 191 TWiM Listener survey

Send your microbiology questions and comments (email or recorded audio) to "mailto:twim@microbe.tv">twim@microbe.tv



13. 190: Exosomes in your nose and in your gut
http://traffic.libsyn.com/twim... download (audio/mpeg, 36.16Mb)

Description:

The TWiM-opods consider two stories about exosomes, vesicles that are shed from cells: those that eliminate airway pathogens, and those from the plants we eat that shape our gut microbiome.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Michele Swanson.

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app.

Become a patron of TWiM.

Links for this episode

Exosome swarms eliminate airway pathogens (J Aller Clin Immunol) Exosome release from Bacteria, Eukaryotes, Archaea (Infect Immun) Plant exosomes shape gut microbiome (Cell Host Microbe) Image credit Subscribe to MicrobeTV on YouTube TWiM Listener survey

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



14. 189: Salmonella BonJovi
http://www.microbe.tv/twim/twi... download (audio/mpeg, 32.61Mb)

Description:

The TWiM team considers the state of the world’s fungi as revealed by a report from the Kew Royal Botanical Gardens, and how Salmonella loses motility to evade host defenses.

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter, and Michele Swanson

Take our listener survey. Thanks! asm.org/twimpoll

Subscribe to TWiM (free) on iTunesGoogle PodcastsStitcherAndroidRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a Patron of TWiM!

Links for this episode:

Subscribe to MicrobeTV on YouTube State of the World’s Fungi 2018 Salmonella loses motility to avoid inflammasome activation (Cell Rep)

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



15. 188: Turducken antibiotics
http://www.microbe.tv/twim/twi... download (audio/mpeg, 37.04Mb)

Description:

The TWiM rock stars show how to modify gram-positive antibiotics so they can kill gram-negative cells, and bacteria that have both DNA and RNA in their genome.

Hosts: Vincent Racaniello and Michael Schmidt

Links for this episode

Antibiotics for gram-positives that kill gram-negatives (J Med Chem) Sideromycin commentary (Am Council Sci Health) Bacterial genome with DNA and RNA (J Am Chem Soc)

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app.

Become a patron of TWiM.



16. 187: Rounding up the bees
http://www.microbe.tv/twim/twi... download (audio/mpeg, 30.51Mb)

Description:

The TWiM people reveal that phages must cooperate to overcome CRISPR-Cas defenses, and the effect of the herbicide glyphosate on the gut microbiome of honey bees.

Hosts: Vincent Racaniello, Elio SchaechterMichael Schmidt, and Michele Swanson

Subscribe to TWiM (free) on iTunesGoogle PodcastsStitcherAndroidRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a Patron of TWiM!

Links for this episode:

Phages Cooperate to Overcome CRISPR-Cas Immunity (Cell) Glyphosate perturbs gut microbiota of honey bees (PNAS) Letters read on TWiM 187

17. 186: Crypto-metamorphosis
http://www.microbe.tv/twim/twi... download (audio/mpeg, 33.67Mb)

Description:

The TWiM team describe the involvement of a microbiome in snail metamorphosis, and using Listeria to kill tumors.

Hosts: Vincent Racaniello, Michael Schmidt, and Michele Swanson.

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app.

Become a Patron of TWiM!

Links for this episode

Infectious diseases after Florence (Med Inf Dis) Cryptic niche switching in gastropod (Proc Roy Soc B) Metamorphosis then no eating (NY Times) Listeria promotes tumor rejection (PNAS) Image credit LADD pathway (jpg) LADD (Aduro Biotech) Crawling cells and comet tails (YouTube) Letters read on TWiM 168

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

 



18. 185: There’s no moa Moa
http://www.microbe.tv/twim/twi... download (audio/mpeg, 31.37Mb)

Description:

The TWiM team considers the increasing tolerance of Enterococcus to handwash alcohols, and how the study of DNA in ancient dung reveals the diet and parasite burden of extinct New Zealand birds.

Subscribe to TWiM (free) on iTunesGoogle PodcastsStitcherAndroidRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a Patron of TWiM!

Episode Links:

Hand sanitizer alert (Emerg Inf Dis) Bacteria becoming hand sanitizer tolerant (NPR) Increasing tolerance of Enterococcus to handwash alcohols (Sci Transl Med) Coprolites and the Moa (PNAS) After Hurricane Florence, Significant Worry Over Infectious Diseases

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

 



19. 184: CRISPR-Cas immune systems
http://www.microbe.tv/twim/twi... download (audio/mpeg, 39.50Mb)

Description:

Sam Sternberg discusses his work on exploring and exploiting CRISPR-Cas immune systems, beginning as a graduate student with Jennifer Doudna, at a biotech start-up, and in his laboratory at Columbia University.

Host: Vincent Racaniello

Guest: Sam Sternberg

 Become a Patron of TWiM!

Links for this episode Sternberg Laboratory at Columbia Mechanism of substrate selection by Cas9 (RNA) DNA interrogation by Cas9 (Nature) Conformational control of DNA target cleavage by Cas9 (Nature) A Crack in Creation by Doudna and Sternberg What if we could rewrite the human genome? (YouTube) Sam Sternberg

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



20. 183: Two symbioses
http://www.microbe.tv/twim/twi... download (audio/mpeg, 26.19Mb)

Description:

The TWiMpeeps discuss two symbioses: a parasitoid bacterium of a heterotrophic protist, and fungal parasites in cicadas.

Become a patron of TWiM.

Links for this episode:

Parasitoid bacterium of protist (bioRxiv) Fungal symbiont recruitment in cicadas (PNAS) Fly by virus (TWiEVO 33) The Atlantic “How to Tame a Zombie Fungus” by Ed Yong Image credit Letters read on TWiM 183

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



21. 182: A micro story with macro implications
http://www.microbe.tv/twim/twi... download (audio/mpeg, 30.18Mb)

Description:

The TWiM hosts reveal how to test antimicrobial susceptibility in less than 30 minutes, and a carbonate-sensitive phytotransferrin in diatoms that controls iron uptake.

Become a Patron of TWiM!

Links for this episode:

Legionnaire’s Disease with Michele Swanson Antibiotic susceptibility in less than 30 min (PNAS) S. saprophyticus growing in microfluidic chip (movie, PNAS) Mother machine (Jun lab) E. coli growth in mother machine (YouTube) Diatom phytotransferrin (Nature) CRISPR tool kit (Nat Commun) A Crack in Creation by Doudna and Sternberg CRISPR/Cas9 for undergrads (BMBE) John Oliver on gene editing (YouTube) Image credit Letters read on TWiM 182

 

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



22. 181: Dr. Warhol’s Periodic Table of Microbes
http://traffic.libsyn.com/twim... download (audio/mpeg, 26.63Mb)

Description:

Vincent speaks with John Warhol about state microbes, the Periodic Table of the Microbes, and why microbiology is cooler than astrophysics, but they have better TV shows.

Host: Vincent Racaniello

Guest: John Warhol

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app.

Become a patron of TWiM.

Links for this episode

State Microbe (Wikipedia)

Micro Minutes! (tumblr)

Warhol Science on Etsy

Periodic Table of Microbes (Amazon)

Image credit

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



23. 180: Microbecentricity with Mark O. Martin
http://traffic.libsyn.com/twim... download (audio/mpeg, 29.55Mb)

Description:

Vincent speaks with Mark O. Martin about microbial centricity, teaching undergraduates microbiology, lux art, painting with glowing bacteria, tardigrades and much more at ASM Microbe 2018.

Host: Vincent Racaniello

Guest: Mark O. Martin

Subscribe to TWiM (free) on Apple Podcasts, Google Podcasts, Android, RSS, or by email. Get the entire ASM Podcast Network via our Microbeworld app.

Become a patron of TWiM.

Links for this episode

Microbial menagerie

All creatures great and small

Carski Award

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



24. 179: Viable but not culturable
http://traffic.libsyn.com/twim... download (audio/mpeg, 34.90Mb)

Description:

The TwiModulators discuss aerosolization of bacteria and viruses in an ocean-atmosphere mesocosm, and how the common practice of decontaminating produce with chlorine produces viable but non-culturable pathogens.

Become a patron of TWiM.

Links for this episode:

Taxon-specific aerosolization of bacteria and viruses (Nat Commun) Chlorine produces viable but non-culturable bacteria (mBio) Chlorine washing fails bacteria test (Guardian) Foodborne illness in US: Major pathogens (CDC) Chlorine dilution calculator (Public Health Toronto)

Multistate foodborne outbreak investigations (CDC)



25. 178: Corals are sexy with Christina Kellogg
http://www.microbe.tv/twim/twi... download (audio/mpeg, 29.74Mb)

Description:

The TWiM team travels to ASM Microbe 2018 in Atlanta, Georgia to speak with Christina Kellogg about her career and her research on coral microbial ecology.

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter and Michele Swanson

Guest: Christina Kellogg

Subscribe to TWiM (free) on iTunesStitcherAndroidRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a Patron of TWiM!

Links for this episode:

Christina Kellogg on twitter Coral microbial ecology Coral reef ecosystem studies Connectivity of vulnerable reefs

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



26. 177: Microbial sibling conflict
http://www.microbe.tv/twim/twi... download (audio/mpeg, 25.08Mb)

Description:

The TWiM team discuss bacteriophage evolution in a dairy plant, and killing of less fit cells among social microbes.

Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode

A decade of phage evolution (Appl Env Micr) Animation of phage infection (Vimeo) Double agar assay for phage (Dairy Science) Sibling conflict among social bacteria (mBio)

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



27. 176: Elio has lots of colanic acid
http://www.microbe.tv/twim/twi... download (audio/mpeg, 27.45Mb)

Description:

Vincent, Michael and Elio note the passing of Stanley Falkow, give E. coli an archaeal membrane, and show how the microbiome can make worms live longer.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a patron of TWiM.

Links for this episode

Fecal transplants in the good old days (STC) Stanley Falkow, 84 Loss of an old army buddy (STC) Giving E. coli an archaeal membrane (PNAS) Microbiome tunes host longevity (Cell) Letters read on TWiM 176

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



28. 175: Neomycin is antiviral
http://www.microbe.tv/twim/twi... download (audio/mpeg, 28.96Mb)

Description:

The TWiM team notes the passing of Allan Campbell, and explains how aminoglycoside antibiotics like neomycin enhance host resistance to viral infection.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Michele Swanson.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a patron of TWiM.

Links for this episode:

Happy Birthday, Elio! (STC) Allan Campbell, 88 (Stanford News) Life in Science by Allan Campbell (Bacteriophage) Aminoglycosides inhibit viral infection (Nat Micro) Image credit Letters read on TWiM 175

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



29. 174: A Gathering Typhoid Storm
http://www.microbe.tv/twim/twi... download (audio/mpeg, 28.64Mb)

Description:

The TWiMsters explain why untreatable typhoid fever might be on the way, and the evolution of fungal virulence in tropical frogs.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a patron of TWiM.

Links for this episode

Extensively drug resistant Salmonella typhi (mBio)

A Gathering Storm (mBio)

Typhoid vaccine recommendations (CDC)

Changes in dynamics of frog fungal disease (Science)

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 



30. 173: Gee whiz in style
http://www.microbe.tv/twim/twi... download (audio/mpeg, 40.29Mb)

Description:

The Masters of the Microbiological Universe discuss the humongouest fungus, and a commensal bacterium that protects against skin neoplasia.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a patron of TWiM.

Links for this episode

Fertile prototaxites (Proc Royal Soc B)

The humongousest fungus (STC)

Commensal Staphylococcus protects against skin cancer (Sci Adv)

Letters read on TWiM 173

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 



31. 172: Unfolding relaxases and soil malacidins
http://www.microbe.tv/twim/twi... download (audio/mpeg, 33.73Mb)

Description:

The TWiMmers discuss culture-independent discovery of malacidin antibiotics, and unfolding of relaxase during bacterial conjugation.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a patron of TWiM.

Links for this episode

Malacidins from soils (Nat Micro)

Excellent antibiotic resistance threat report (CDC, pdf)

Jo Handelsman on Women’s History Month (CBS)

Unfolding relaxase during bacterial conjugation (J Bact)

Letters read on TWiM 172

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



32. 171: If you give a bee a fungus
http://traffic.libsyn.com/twim... download (audio/mpeg, 27.79Mb)

Description:

The TWiM team explores a stingless bee that requires a fungal steroid to pupate, and colonic biofilms containing tumorigenic bacteria in patients with colorectal polyps.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a patron of TWiM.

Links for this episode

Bee larvae require fungal steroid to pupate (Sci Rep)

Biofilm refuge for tumorigenic bacteria (Science)

Letters read on TWiM 171

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



33. 170: Rats, lice, and nanoparticles
http://traffic.libsyn.com/twim... download (audio/mpeg, 25.66Mb)

Description:

The TWiM team reveals that spread of plague was likely by human ectoparasites, not rats, and deconstruct a durable, broadly protective protein nanoparticle influenza virus vaccine.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

Become a patron of TWiM.

Links for this episode

Ectoparasites and plague (PNAS)

SIR model for spread of disease (MAA)

Protein nanoparticle flu vaccines (Nat Commun)

Food washing (USDA)

Image credit

Letters read on TWiM 170

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 



34. 169: Breatharian Bacteria
http://traffic.libsyn.com/twim... download (audio/mpeg, 28.67Mb)

Description:

The cast of TWiM reveals how uropathogenic E. coli use a copper-binding protein to treat copper as a nutrient or a toxin, and Antarctic soil bacteria that survive on trace atmospheric gases.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

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Links for this episode

Copper import in E. coli (Nat Chem Biol)

Conversion of OD to cells/ml for E. coli

Nutritional immunity with Jennifer Bomberger (TWiM#141)

Microbes live on atmospheric trace gases in Antarctic soil (Nature)

Antarctic terrestrial ecosystem (SciHub)

Hypolith (Wikipedia)

Breatharians (Broadly)

Image credit

Letters read on TWiM 169Letters read on TWiM 169

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



35. TWiM #168: The lesser of two weevils
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Description:

Dickson joins the TWiM team to discuss the nasal microbiota of dairy farmers, and attenuation of bacterial virulence by quorum sensing in the maize weevil.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Michele Swanson.

Guest: Dickson Despommier

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Links for this episode:

Nasal microbiota of dairy farmers (PLoS One)

Measuring species richness, diversity, similarity (pdf one, pdf two)

Quorum sensing attenuates virulence (Cell Host Micr)

 

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 

 



36. TWiM #167: I have one word for you: Flink
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Description:

How pandemic influenza viruses suppress immunogenic cell death, and 3D printing of bacteria into functional materials.



37. TWiM #166: Dark fermentation
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Description:

Vincent and Elio discuss the reason for poor efficacy of one of the influenza virus vaccines, and using a hyperthermophilic anaerobe to produce hydrogen from fruit and vegetable wastes in seawater.

Hosts: 

Vincent Racaniello and Elio Schaechter.

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Links for this episode

Glycosylation site on influenza H3N2 viruses (PNAS)

Biohydrogen production by Thermotoga (Waste Man)

Image credit

Letters read on TWiM 166

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



38. TWiM #165: Pumping Copper
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Description:

The TWiM team discusses the use of copper on exercise weights to reduce bacterial burden, and the mechanism of antigenic variation by which a fungus that causes severe pneumonia escapes the immune system.

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson

Links for this episode:

Reducing bacteria on exercise weights with copper (Am J Inf Contr) Antigenic variation in Pneumocystis jirovecii (mBio) Letters read on TWiM 165

39. TWiM #164: Indiana Quorum
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Description:

From Indiana University, Vincent speaks with Ankur, Julia, and Xindan about their careers and their work on horizontal gene transfer, quorum sensing, and chromosome organization in bacteria.

Guests: Ankur Dalia, Julia Van Kessel, and Xindan Wang

Watch the video version! https://www.youtube.com/watch?v=ifGCe-qfnA0

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Links for this episode:

Dalia laboratory Van Kessel laboratory Wang laboratory Indiana U Dept of Biology Vibrio DNA uptake and chitin (Environ Micro) Activation of quorum-sensing genes (Mol Micro) Structural maintenance of chromosome complexes (Science)

40. TWiM #163: Saliva and sptR/S
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Description:

This episode is all about saliva: how certain bacteria survive in it, and how swallowing saliva might cause intestinal inflammation.

Links for this episode:

Genes for the Streptococcus pyogenes fitness in human saliva (mSphere) Swallowed bacteria drive colonic inflammation (Science) Intestinal inflammation induced by oral bacteria (Science) Human oral microbiome (J Bact) T cell subsets (Nat Rev Imm) Image credit

41. TWiM #162: Intracellular bacteria with flagella
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Description:

The TWiM hosts and associated microbiomes review a fungus destroying salamanders in Europe, and genes for flagella in intracellular bacteria.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

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Links for this episode

Fungus killing fire salamanders (Nature)

Chlamydia with flagella (ISME J)

Flagellar movement in rickettsia (PLoS One)

Image credit

Letters read on TWiM 162

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

 



42. TWiM #161: Eros, a bacterial aphrodisiac
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Description:

From the TWiM team, a discussion of Hurricane Harvey microbiology, and a bacterial enzyme that induces eukaryotic mating.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Links for this episode

Tainted Houston floodwaters (NYTimes)

Peter Hotez on TWiP 29

FAQ: Microbiology of Built Environments, American Academy of Microbiology

Microbiomes of the Built Environment:  A Research Agenda for Indoor Microbiology, Human Health, and Buildings, The National Academies of Sciences

Eukaryotic mating induced by bacterial enzyme (Cell)

Image credit: Arielle Woznica

Nicole King on TWiEVO 11

Letters read on TWiM 161

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com



43. TWiM #160: On the road to virus
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Description:

The TWiM team provides an update on Zika virus, and reveals a plasmid on the road to becoming a virus.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Michele Swanson.

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Links for this episode

Regional Zika update, Americas (PAHO, WHO)

FGCU, Zika (TWiV 454)

CDC Graphic of US zika cases as of May 2017

Archaeal plasmid travels cell to cell via vesicles (Nature Micro)

Letters read on TWiM 160

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com



44. TWiM #159: Immunophage synergy
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Description:

The TWiM team pays a tribute to Chris Condayan, and investigates the synergy between virus and the innate immune system for clearing bacterial pneumonia by phage therapy.



45. TWiM #158: The bottom line
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Description:

The TWiM team considers a report on prokaryotic viral DNA in mammalian brain, and how diarrhea is beneficial, by clearing enteric pathogens.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Links for this episode

Prokaryotic viral sequence in the brain (PNAS)

Diarrhea clears enteric pathogens (Cell Host Microbe)

Tight junction biology (Turner Laboratory)

Letters read on TWiM 158

 

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 



46. TWiM #157: Back to the ancestor
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Description:

The TWiMbionts explore the role of bacteria in the genesis of moonmilk, and how ancient host proteins can be used to engineer resistance to virus infection.

Hosts: 

Vincent Racaniello, Michele Swanson and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Links for this episode

Role of Streptomyces in moonmilk (bioRxiv)

TWiM 51: Cave science with Hazel Barton

Moonmilk (Wikipedia)

Ancient proteins for virus resistance (Cell Rep)

Image credit

Letters read on TWiM 157

 Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 



47. TWiM #156: Gifted microbes and defensive symbiosis
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Description:

The TWiM team explains the use of microbial genome mining to identify new drugs, and how a bacterial symbiont protects flies against parasitoid wasps.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

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Links for this episode

Molecular beacons identify gifted microbes (J Antibiot)

Defensive symbiosis (PLoS Path)

Letters read on TWiM 156

Image

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv

 



48. TWiM #155: Living in the stomach of a cell
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Description:

Michele updates the TWiMers on Legionella in the Flint water supply, and Elio informs us about how horizontally acquired biosynthesis genes boost the physiology of Coxiella burnetii.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Links for this episode

Legionella in Flint water (The Scientist)

Q fever with Robert Heinzen (TWiM Special)

Horizontally acquired genes boost C. burnetii (Front Cell Inf Micro)

Image credit

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



49. TWiM #154: Rigor, lotteries, and moonshots
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Description:

At Microbe 2017 in New Orleans, the TWiM team speaks with Arturo Casadevall about his thoughts on the pathogenic potential of a microbe, rigorous science, funding by lottery, and moonshot science.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

Watch the video version recorded live at ASM Microbe 2017!

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a patron of TWiM.

Links for this episode

Pathogenic potential of a microbe (mSphere)

Rigorous science (mBio)

Funding by lottery (mBio)

Moonshot science (mBio)

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



50. TWiM #153: Covert pathogenesis
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Description:

The TWiM team ventures into preprint space with an analysis of type VI secretion across human gut microbiomes, and provide insight into urinary tract infection: how bladder exposure to a member of the vaginal microbiota triggers E. coli egress from latent reservoirs.

Hosts: 

Vincent Racaniello, Michael Schmidt, Michele Swanson and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a patron of TWiM.

Links for this episode

ASM Microbe 2017

TWiM Live from ASM Microbe 2017

Landscape of type VI secretion (BioRxiv)

Type VI secretion structure (jpg)

Activation of dormant E. coli in urinary tract infection (PLoS Path)

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



51. TWiM #152: Wooden steps
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Description:

The TWiMmers get cozy with symbionts: the bacteria that allow a giant shipworm to oxidize sulfur, and algae that live within salamander cells.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Elio Schaechter.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Links for this episode

ASM Microbe 2017

Chemoautotrophic symbiosis in giant shipworm (PNAS)

There’s gold in them hills (TWiM 97)

Vertebrate-algal symbiosis (eLife)

Letters read on TWiM 152

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



52. TWiM #151: Bat and moth antimicrobials
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Description:

The TWiMsters discuss potential new sources of antimicrobial compounds from unusual places: the skin of bats and the intestines of moths.

Hosts: 

Vincent Racaniello, Michael SchmidtElio Schaechter, and Michele Swanson.

Subscribe to TWiM (free) on iPhone, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Become a patron of TWiM.

Links for this episode

JMBE science communication issue

Bat sources of novel antifungals (AEM)

White nose syndrome in US (jpg)

White nose syndrome fact sheet (pdf)

Symbiont-derived antimicrobials (Cell Chem Cell)

Bacteriocins (Wikipedia)

Letters read on TWiM 151

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv



53. TWiM #150: Microbiology is where it’s at
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Description:

In recognition of National Medical Laboratory Professionals Week, Robin Patel speaks with the TWiM team about directing a clinical bacteriology laboratory, and how an observation made by a laboratory technologist lead to the finding that Ureaplasma species can cause a system metabolic disturbance, hyperammonemia.

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson

Guest: Robin Patel

Links for this episode:

National Laboratory Professionals Week Mayo Clinic Clinical Microbiology Laboratory Infectious Diseases Laboratory, Mayo Clinic Murine model of Ureaplasma hyperammonemia (Eur J Clin Microbiol Infect Dis) Ureaplasma and human hyperammonemia (Sci Transl Med)

Become a patron of TWiM.

 



54. TWiM #149: You’re going to learn R
http://www.asm.org/index.php/p... download (audio/mpeg, 28.88Mb)

Description:

The TWiM team speaks with Pat Schloss about assigning sequence data to operational taxonomic units, and his experience with mSphere Direct, a new way of submitting papers for publication.

Hosts: 

Vincent Racaniello, Michael SchmidtElio Schaechter, and Michele Swanson.

Special guest: Pat Schloss

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Links for this episode

Schloss Laboratory

OptiClust (mSphere)

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55. TWiM #148: Neanderthal Dentistry
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Description:

Vincent, Elio, and Michael reveal what Neanderthals ate from analysis of DNA in their teeth, and new CRISPR-Cas systems found in the genomes of uncultured microbes.

Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt.

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Links for this episode

Ancient DNA in Neanderthal teeth (Nature) New CRISPRs from metagenomics (Nature) CRISPR/cas explained (Wikipedia) ASM Conference for Undergraduate Educators Image credit Letters read on TWiM 148

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twim

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56. TWiM #147: The Public Goods Dilemma
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Description:

The TWiM hosts reveal why phosphorus is essential for fungal brain disease, and how bacteria kill local competitors to favor the evolution of public goods cooperation.

Hosts: 

Vincent Racaniello, Michele Swanson, Michael Schmidt, and Elio Schaechter.

Links for this episode

Phosphate needed for Cryptococcus brain disease (mSphere)

Type VI killing drives phase separation (Nat Rep)

Type VI secretion review (Phil Trans Roy Soc)

Microbial cooperation and conflict (TedX)

Image credit

Letters read on TWiM 147

Become a patron of TWiM.

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twim

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57. TWiM #146: Viral arbitrium
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Description:

Vincent, Elio and Michael discuss the finding of a prion in bacteria, and how communication between bacteria guides the decision between lysis and lysogeny.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Elio Schaechter.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Links for this episode ASM 2017 Election is Open! VOTE HERE Prions in bacteria (Science) Communication guides lysis-lysogeny decisions (Nature)

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58. TWiM Special: Q fever with Robert Heinzen
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Description:

Host: Vincent Racaniello

Guest: Robert Heinzen

At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Robert Heinzen about the work of his laboratory on Q fever and its causative microbe, Coxiella burneti.

 

Become a Patron of TWiM!

Links for this episode Rocky Mountain Laboratory Heinzen Laboratory Small town, big science (TWiM 140)

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



59. TWiM #145: Anything but academic
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Description:

Vincent meets up with Catharine Bosio, Michael Merchlinsky, and Shilpa Gadwal at the ASM Biothreats meeting to talk about careers for scientists outside of the ivory tower.

Become a patron of TWiM.

Links for this episode:

ASM Biothreats 2017 Rocky Mountain Laboratory BARDA

 



60. TWiM #144: Did eukaryotes invent anything?
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Description:

The TWiMers discuss how changes in domestic laundering affect the removal of microorganisms, and assembly of a nucleus-like structure during viral replication in bacteria.

Hosts: 

Vincent Racaniello, Michael SchmidtElio Schaechter, and Michele Swanson.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Links for this episode Laundry hygiene (J Appl Micro) Nucleus-like structure in infected bacteria (Science) Video of nucleus assembly in bacteria (YouTube) Image credit Letters read on TWiM 144

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twim

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61. TWiM #143: E-scaffolds and receptor transfer
http://www.asm.org/index.php/p... download (audio/mpeg, 30.16Mb)

Description:

Vincent, Michael, and Michele explain the use of an electrochemical gradient to eliminate bacterial biofilms, and how phage susceptibility can be transferred by exchange of receptor proteins.

Hosts: 

Vincent Racaniello, Michael Schmidt, and Michele Swanson.

Right click to download TWiM#143 (32 MB .mp3, 66 minutes).

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Links for this episode

Electrochemical scaffold to eliminate persistent biofilms (npj Biofilms Microbiomes)

Experimental setup for electrochemical treatment of biofilm (pdf, from article)

Acquisition of phage sensitivity by transfer of cell receptors (Cell)

Image credit

Letters read on TWiM 143

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

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62. TWiM #142: A membrane-thickness caliper
http://www.asm.org/index.php/p... download (audio/mpeg, 26.92Mb)

Description:

Vincent, Elio and Michele wind up a year of microbial podcasts with a story about the lack of resistance to a crop antifungal compound, and how a bacterium uses a molecular caliper to measure membrane thickness.

Hosts: 

Vincent Racaniello, Elio Schaechter, and Michele Swanson.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode

Phenylpyrroles: Nearly no resistance (Front Micro)

Membrane-thickness caliper (J Bact)

Letters read on TWiM 142

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv 



63. TWiM #141: Nutritional immunity and polymicrobial infections
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Description:

Jennifer joins Vincent, Elio, and Michael to talk about the work of her laboratory on how a respiratory virus enhances bacterial growth by dysregulating nutritional immunity.

Hosts: 

Vincent Racaniello, Elio Schaechter, and Michael Schmidt.

Guest: Jennifer Bomberger

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode

Virus dysregulation of nutritional immunity (PNAS)

Podcast article mentioned by Michael

Compromised defenses (PLoS Path)

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64. TWiM 140: Small town, big science
http://www.microbe.tv/twim/twi... download (audio/mpeg, 46.36Mb)

Description:

Host: Vincent Racaniello

Guests: Marie Antonioli, Bryan Hansen, Forrest Jessop, Kyle Shifflet and Jim Striebel

At the Hamilton, Montana Performing Arts Center, Vincent speaks with three local high school graduates and two high school teachers about how Rocky Mountain Laboratories influenced school science programs and opened up career opportunities.

 

Subscribe to TWiM (free) on iTunesStitcherAndroidRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

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Links for this episode Poster of this event (jpg) Rocky Mountain Laboratories Hamilton, MT high school Video of this episode on YouTube

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



65. TWiM #139: Frackibacter and sticky fingers
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Description:

The TWiM team discusses microbial DNA found on ATM machines in New York City, and how hydraulic fracturing, or fracking, alters microbial ecosystems deep in the Earth.

Hosts: 

Vincent Racaniello, Michael SchmidtElio Schaechter, and Michele Swanson.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Microbial DNA on ATM machines in NYC (mSphere) NYC OpenData Altering deep microbial ecosystems by fracking (Nat Micro) Marcellus Shale Energy and Environment Laboratory Chemicals used for fracking (FracFocus) Marcellus and Utica shale formation map Consequences of fracking (GasBuddy) Image credit

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Register today for the 2017 ASM Scientific Writing and Publishing Online Course at bit.ly/swpoc17

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 



66. TWiM #138: Learning to love uranium and the A-baum
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Description:

The TWiM team brings you a bacterium from a Colorado field site that grows on uranium, and copper resistance in the emerging pathogen Acinetobacter baumannii.

Hosts: 

Vincent Racaniello, Michael SchmidtElio Schaechter, and Michele Swanson.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Kavli Microbiome Ideas Challenge Uranium-respiring bacterium from a field site (PLoS One) Acid mine drainage (Wikipedia) Copper resistance of Acinetobacter baumannii ASM Grant Writing Online Course TWiM #132: Bacteria learn long division Image credit

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 



67. TWiM #137: The battle for oxygen
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Description:

Highlights of the Recent Advances in Microbial Control meeting in San Diego, and expansion of a gut pathogen by virulence factors that stimulate aerobic respiration.

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Fred Neidhardt obituary Recent Advances in Microbial Control Science hero Bill Fenical Virulence factors and aerobic respiration (Science) Image credit Letters read on TWiM 137

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 



68. TWiM #136: Diderms and then monoderms
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Description:

Them TWiM team discusses the importance of neutrophils in microbial infections, and evidence that ancient bacteria had two cell walls.

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Conquering neutrophils (PLoS Path) Ancestral outer membrane in firmicutes (eLife ) Were gram positive rods the first bacteria? (Cell) Image credit Letters read on TWiM 136

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 



69. TWiM #135: Unruly individuals and their unruly friends
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Description: Links for this episode Dysbiosis of microbiome in critical illness (mSphere) Consequences of sewage spill into aquatic environment (App Env Mic) EPA recreational water guidelines (pdf) VRE following sewage spill (Outbreak Radio) FAQ: Human microbiome American gut project British gut project Rob Knight on human microbiome (TED) Rob Knight on TWiM Image credit TWiM 135 Letters

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 



70. TWiM #134: Lipids that live forever
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Description:

Design of a synchronously lysing bacterium for delivery of anti-tumor molecules in mice, and hopanoids, the lipids that live forever, brought to you by the four Microbies of TWiM.

Hosts: Vincent Racaniello, Elio Schaechter, Michael Schmidt, and Michele Swanson.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Bacterial lysis for in vivo delivery (Nature) Coley’s toxins (Iowa Orthop J) Hopanoids, stress tolerance, and nutrient storage (Geobiol) Lipids that last forever (STC) Fattening up microbial geological biomarkers (STC) Money spreads infection (Fut Micro)

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 



71. TWiM #133: Right under our noses
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Description:

Insight into the biology of rhinovirus C from cryo-electron microscopy, and a novel antibiotic from a commensal bacterium that grows in the human nose, from the doctors of TWiM.

Hosts: Vincent Racaniello, Elio Schaechter, and Michael Schmidt.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Cryo-EM of viruses and vaccine design (PNAS) Atomic structure of rhinovirus C (PNAS) Opening windows into the cell (STC) Human commensals produce novel antibiotic (Nature) The nose knows (Nature) Letters read on TWiM 133

Image in audio player: Molecular surface of a Human rhinovirus, showing protein spikes. By: Wiki user: Robin S

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 



72. TWiM #132: Bacteria learn long division
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Description:

Vincent, Elio, and Michele present cell division by longitudinal scission in an insect symbiont, and thermally activated charge transport in microbial nanowires.

Hosts: Vincent RacanielloMichele Swanson and Elio Schaechter.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Cell division by longitudinal scission (mBio) Bacterium learns long division (STC) Charge transport by microbial nanowires (Sci Rep) Mechanism of nanowire conductance (Nat Comm) Using nature to grow batteries (TED) SEM of Y-shaped S. poulsonii (above) - Image credit Extracellular electron transport (below) - image credit

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 



73. TWiM 131: Mice behaving badly
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Description:

Hosts: Vincent Racaniello and Michael Schmidt

Michael and Vincent present Spotlights, brief reviews of classic papers in the Journal of Bacteriology, and explain how a single bacterial species can reverse autism-like social deficits in the offspring of obese mice.

 

Links for this episode Protein secretion in E. coli (J Bacteriol) Plague pathogenesis (J Bacteriol) Reversal of diet induced social defects (Cell) Letters read on TWiM 131

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv



74. TWiM #130: Interkingdom interactions at ASM Microbe
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Description:

Filmed live in Boston, MA at Microbe 2016, David S. Schneider and Vanessa Sperandio talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help us recover.



75. TWiM #129: Dried and wrinkled, smooth and mucoid
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Description:

The arrival in the US of plasmid-mediated resistance to colistin antibiotics, a last line of defense against many gram-negative bacilli, and a quorum sensing system in a eukaryote are topics of this episode hosted by Vincent, Michael, and Michele.

Image: Etest used to determine the minimum inhibitory concentration of an antibiotic for a particular bacterium.

Hosts: Vincent RacanielloMichael Schmidt, and Michele Swanson. 

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode E. coli with mcr-1 on a plasmid in the US (AAC) Emergence of plasmid mediated colistin resistance in China (The Lancet) Major breach in last line of defense (The Lancet) Resistance plasmid families in Enterobacteriaceae (AAC) EUCAST MIC breakpoints (ClinCalc) Role of ASM in microbial resistance one, two (bLogphase) Quorum sensing in fungi (Cell Host Microbe) Image credit Letters read on TWiM 129

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 



76. TWiM #128: A moonlighting phage protein
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Description:

A eukaryote without a mitochondrion, and using a phage enzyme to eliminate intracellular bacteria are two topics discussed by the TWiMers on this episode.

Image (right): An entry in the ASM Agar Art Contest which bears an uncanny resemblance to one of the TWiM hosts.

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Copper and Michael Schmidt in the news (The Scientist) Fair Pay for Postdocs (Huff Post) National Microbiome Initiative (White House) The shrinking mitochondrion (The Scientist) Eukaryote without a mitochondrion (Curr Biol) Why have organelles retained genomes? (Cell Sys) Bugs as drugs (Amer Acad Micro) Phage encoded lysin eliminates intracellular bacteria (eLife)

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/m​icrobe ​and use the promo code MICROBE​.

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 



77. TWiM #127: Subway Snowblowers and Men in Black
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Description:

The TWiM team explores microbes in snowblower vents on the ocean floor, and cleavage of antibody molecules by a Mycoplasma protease.

Image (right): Photograph of the ‘Subway’ snowblower vent on the sea floor at Axial Seamount, Juan de Fuca Ridge. Visible are white ‘snow’ in the vent and orange floc on the seafloor. Credit: Canadian Scientific Submersible Facility and the University of Washington

Hosts: Vincent Racaniello, Elio Schaechter, Michele Swanson, and Michael Schmidt.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Happy Birthday, Elio! In the Company of Microbes Snowblower vents (Front Micro) Deep-sea snowblower vents video (YouTube) Visions 11 cruise photos Mycoplasma capture and cleave IgG (PNAS) Snowblower image (large) Letters read on TWiM 127

This episode is sponsored by ASM Agar Art Contest and ASM Grant Writing Course

Send your microbiology questions and comments (email or mp3 file) to twim@microbe.tv 



78. TWiM #126: I’m not scared of zebrafish and mice and bears (oh my!)
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Description:

The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele.

Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Microbiome of hibernating brown bear and energy metabolism (Cell Rep) Ten animals that hibernate (Cons Inst) Zebrafish model of sepsis (mSphere) Image credit Letters read on TWiM 126

This episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

 



79. TWiM #125: A minimal cell operating system
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Description:

Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt.

A deep sequencing study of commercially available probiotics, and design and synthesis of a minimal bacterial genome are the topics tackled by Vincent, Michael, and Michele on this episode of TWiM.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Culture-independent surveillance of probiotics (mSphere) Design and synthesis of a minimal bacterial genome (Science) J. Craig Venter Institute Image credit Letters read on TWiM 125

This episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

 

 



80. TWiM #124: Fungal pirates
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Description:

Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt.

Vincent, Michael, and Michele reveal how a fungal protease blunts the innate immune response and promotes pathogenicity.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Michele on Flint Legionella outbreak (Detroit News) Fungal mimicry of a mammalian aminopeptidase (Cell Host Micr)

 

This episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.



81. TWiM #123: A microbial MAGE
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Description:

Hosts: Vincent RacanielloMichael Schmidt, and Elio Schaechter.

Guest: Harris Wang

Harris joins Vincent, Elio, and Michael to describe multiplex automated genome engineering, a method for targeting many modifications in a population of bacterial cells.

Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode  MAGE - Multiplex automated genome engineering (Nature) Genome-scale promoter engineering (Nat Methods) Manipulating microbial communities in situ (Trends Genet) Engineering human microbiomes (Meth Mol Biol) Genome-scale engineering (Mol Syst Biol) Economic framework of microbial trade (PLoS One) Tardigrade t-shirt Image credit

This episode is sponsored by Microbe Magazine Podcast and ASM Microbe 2016

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv.

 



82. TWiM #122: Mayonii, microRNAs and the microbiome
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Description:

Vincent, Michele, and Michael reveal the discovery of a new species of the spirochaete that causes Lyme disease, and fecal microRNAs that shape the gut microbiome.

Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode

Identification of a novel Borrelia species causing Lyme disease (Lancet Inf Dis)

Parasite wonders with Bobbi Pritt (TWiP 75)

Reported cases of Lyme disease (CDC)

Signs and symptoms of Lyme disease (CDC)

Multilocus sequence typing

Borrelia MLST database

American Academy of Microbiology FAQ Human microbiome

Host fecal microRNA shapes gut microbiota (Cell)

Image credit

C.U.R.E. the game

Live Tiny, Die Never - Tardigrade T-shirt

This episode is sponsored by Microbe Magazine Podcast and ASM Microbe 2016

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

 



83. TWiM #121: A plague of pathogens
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Description:

Host: Vincent Racaniello

Special guests: Rebekah Kading and Wyndham Lathem

From the ASM Biodefense and Emerging Diseases Research meeting, Vincent speaks with Rebekah and Wyndham about their work on Rift Valley Fever virus and other vector-borne pathogens, and the evolution and pathogenesis of Yersinia pestis, the agent of plague.

Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode  Rift Valley fever virus risk (Emerg Micr Inf) Predicting Rift Valley fever virus transmission (PLoS NTD) Culex in New York City (BioOne) Early emergence of Y. pestis (Nature Comm) Pneumonic plague (Trends Micro)

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.



84. TWiM #120: Snakes in trouble
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Description:

Hosts: Vincent Racaniello and Elio Schaechter.

Vincent and Elio marvel in the finding that a phage tail-like structure from a marine bacterium stimulates tubeworm metamorphosis, and reveal Ophidiomyces as a cause of snake fungal disease.

Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode  Tubeworm metamorphosis by phage tail-like structures (Science) Cell enzyme becomes viral capsid protein (virology blog) Snake fungal disease in the laboratory (mBioi) Snake fungal disease in cottonmouths (PLoS Biol) Snake fungal disease (pdf) Image credit

This episode is sponsored by ASM Grant Writing Institute Online Webinar and 32nd Clinical Virology Symposium

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv.

 



85. TWiM #119: Power of one
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Description:

Hosts: Vincent RacanielloMichael Schmidt, and Elio Schaechter.

The microbophiles investigate the ratio of bacterial to human cells in our bodies, and how placing solar panels on a bacterium enables it to carry out photosynthesis.

Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode  Revised estimates of human and bacterial cells in the body (biorxiv) Power of ten (Small Things Considered) Solar-to-chemical production in bacteria (Science) Letters read on TWiM 119

This episode is sponsored by ASM Grant Writing Institute Online Webinar and 32nd Clinical Virology Symposium

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv.

Thumbnail image: Cell structure of a gram positive bacterium. This vector image is completely made by Ali Zifan - Own work; used information from Biology 10e Textbook (chapter 4, Pg: 63) by: Peter Raven, Kenneth Mason, Jonathan Losos, Susan Singer · McGraw-Hill Education.

 



86. TWiM #118: Spore-drops keep fallin’ on my head
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Description:

Hosts: Vincent Racaniello, Elio Schaechter and Michele Swanson

On the last episode for 2015, Vincent, Elio, and Michele discuss how soil amoeba hunt nematodes in packs, and the role of mushrooms as rainmakers.

Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode  Pack hunting by a common soil amoeba on nematodes (Environ Micro) Mushrooms as rainmakers (PLoS One) Mushroom by Nicholas Money In the Company of Mushrooms by Elio Schaechter Image credit Letters read on TWiM 118

This episode is sponsored by ASM Microbe 2016 and ASM Biodefense

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv.



87. TWiM #117: Finding the comammox
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Description:

The TWiM team marvels over the finding of a completely nitrifying Nitrospira, and horizontal gene transfer from Wolbachia into an animal genome.

Links for this episode:

Complete nitrification by Nitrospira bacteria (Nature one, two) Enigmatic comammox (PhysOrg) Ammonia-oxidizing bacteria (Ann Rev Micro) Tardigrade controversy (SciAlert) Horizontal gene transfer from Wolbachia to grasshopper (PeerJ) Thumbnail Image (nitrogen cycle) credit Letters read on TWiM 117


This episode is sponsored by ASM Microbe 2016 and ASM Biodefense

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv.



88. TWiM #116: Chewates and coconuts
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Description:

Hosts: Vincent RacanielloElio Schaechter and Michele Swanson

The TWiMeriti reveal a Brazilian social bee that must cultivate a fungus to survive, and diet-mediated reduction in gut colonization by Candida albicans.

Links for this episode  Bee cultivates fungus to survive (Curr Biol) Diet reduces C. albicans gut colonization (mSphere) mSphere, a new open-access ASM journal Image credit Letters read on TWiM 116

This episode is sponsored by ASM Biodefense and the 32nd Clinical Virology Symposium.

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv.



89. TWiM #115: Profiling the Poglianos
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Description:

Vincent visits the laboratories of Kit and Joseph Pogliano on the campus of the University of California, San Diego, where he learns about their work on the bacterial cytoskeleton, sporulation, and the effects of antibiotics on bacterial cells.

Visit microbeworld.org/twim for complete shownotes including the special video version of this episode. Thanks for listening and watching!



90. TWiM #114: Milestones in Blue
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Description:

Vincent, Elio, and Michele meet with Harry Mobley, Mary O’Riordan, and Vince Young at the University of Michigan, during the designation of the Department of Microbiology and Immunology as a Milestones in Microbiology site. They discuss how the laboratory has advanced the science and teaching of microbiology, and discuss faculty work on uropathogenic E. coli, induction of stress by bacterial infection, and the gut microbiome.

Visit microbeworld.org/twim for more including the special video version of this episode.



91. TWiM #113: Waves of Change
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Description:

Vincent meets up with Romney and Duncan at the 79th annual meeting of the Southern California branch of the American Society for Microbiology, where they talk about emerging technologies for antimicrobial susceptibility testing, and next generation sequencing and advanced molecular diagnostics.

Visit microbeworld.org/twim to watch the video version and for complete shownotes including links mentioned.



92. TWiM #112: Mushroom pickers and mushroom kickers
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Description:

The TWiM team wonders why definitions in biology often change, and discuss how the small molecule terrein is important for the growth of a soil fungus.

Image: Lesion formation on banana surfaces infected with Aspergillus terreus. Source

Links mentioned:

 

ASM Undergraduate Research Capstone Program ASM Undergraduate Fellowship Program Regulation of terrein production in Aspergillus terreus

Visit microbeworld.org/twim for more.

 



93. TWiM #111: Ancientbiotics and modernbiotics
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Description:

Hosts: Vincent RacanielloMichael Schmidt, and Elio Schaechter.

The TWiMitos discuss the reconstruction of a 1,000-year-old antimicrobial remedy, and using gallium as an antimicrobial in the battle for iron.

Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode  1,000 year old antimicrobial (mBio) Siderophore quenching with gallium (Evol Med Pub Health) Evolutionary dynamics of public goods (J Evol Biol) Image credit Letters read on TWiM 111

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.



94. TWiM #110: Exploring unseen life with unpronounceable words
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Description:

The TWiM team focuses on the gut microbiome, from a single member, Akkermansia muciniphila, to the effect of antibiotics on its composition and colonization resistance against C. difficile.

Subscribe to TWiM (free) on iTunesStitcherAndroidRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode 

Agar art contest

Akkermansia muciniphilia and obesity (Gut)

A. muciniphilia genome (Biol Direct)

Alterations of gut microbiota and C. difficile colonization (mBio)

Science Delivered

Girls Who Code

F.E.M.M.E.S.

Association for Women in Science

UMich Host-Microbiome Initiative

UMich anaerobic chamber room (png)



95. TWiM #109: Precision killing
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Description:

The TWiM cohort discusses the use of antimicrobial peptides to target specific bacteria in the microbiome, and how the intracellular bacterium Wolbachia selectively kills male hosts.

 

Links for this episode:

Antimicrobial peptides to modulate microbial ecology (PNAS)

Targeting specific bacteria in the oral microbiome (Trends Micro)

How Wolbachiakills male hosts (PLoS Biol)

Wolbachia phage on TWiV 332

 

Image: Transmission electron micrograph of Wolbachia within an insect cell.

By: Scott O'Neill - Genome Sequence of the Intracellular Bacterium Wolbachia. PLoS Biol 2/3/2004: e76.



96. TWiM #108: Vaccine in the time of cholera
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Description:

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter and Michele Swanson.  

The professors of TWiM discuss a University of Wisconsin plan for rescuing biomedical research in the US, and results of a clinical trial in Bangladesh of an oral cholera vaccine.

Subscribe to TWiM (free) on iTunesStitcherRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode Rescuing biomedical research (eLife) Rethinking graduate and postdoc education (iBiology) Oral cholera vaccine trial (Lancet)  Inexpensive cholera vaccine (NYTimes) Image credit Letters read on TWiM 108

97. TWiM #107: The battle in your bladder
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Description:

Hosts: Vincent Racaniello and Michael Schmidt.

Vincent and Michael discuss the highly diverse microbiome of uncontacted Amerindians, and how the composition of human urine plays a role in the battle for iron.

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode Microbiome of uncontacted Amerindians (Sci Adv) Urinary composition controls siderocalin activity (J Biol Chem) Urine acidity and UTI susceptibility (Infect Cont Today) Image (from pdb file 3cmp) shows siderocalin (magenta) complexed with iron (orange) and enterobactin (sticks)

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.



98. TWiM #106: Lawn mower disease
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Description:

 

Vincent and Michael speak with Katy Bosio about her research on pathogenesis, immunity, and vaccines against Franciscella tularensis, the causative agent of tularemia.



99. TWiM #105: Real bugs with legs
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Description:

The TWiM team reviews the microbiological safety of herbs in the United Kingdom, and how a peptide from the milkweek bug binds the ribosome and inhibits bacterial protein synthesis.

 

Links for this episode:

 

Microbes in whole-leaf herbs (J Appl Micro)

Antimicrobial peptide blocks ribosome (Nat Struct Mol Biol)

Bacterial protein synthesis (Micro Mol Biol Rev)

Antimicrobial peptides (Nature)

The battle for tryptophan (Front Cell Infect Micro)

Image credit

100. TWiM #104: Feed me polyamines, biofilm
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Description:

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter and Michele Swanson.  

The TWiM team discusses how measles vaccination protects against other infectious diseases, and links between bacterial biofilms and colon cancer.

Subscribe to TWiM (free) on iTunesStitcherRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode

Measles vaccination prevents all-cause infectious disease (Science)

Master of contagion (The Loom)

Video: Measles incidence to immunomodulation (Science)

FAQ: Adult vaccines

Metabolism links biofilms and colon cancer (Cell Metab)

Scripps Center for Metabolomics

Scripps metabolite database

Image credit

Sponsors for this episode: SciMedSolutionsICAAC-ICC

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

 



101. TWiM #103: The battle for iron
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Description:

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter and Michele Swanson

The TWiM team is amazed by the ocelloid, and an evolutionary battle for iron between mammalian transferrin and bacterial transferrin-binding protein.

Subscribe to TWiM (free) on iTunesStitcherRSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Links for this episode A unicellular camera-type eye structure (PLoS One) Escape from iron piracy (Science) Iron in infection and immunity (Cell Host Micr) Nutritional immunity (Nat Rev Micro) Evolutionary Path (Matthew Barber) Image credit: Janet Iwasa Sponsors for this episode: SciMedSolutionsICAAC-ICC

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

 



102. TWiM #102: Happiness is the spore-formers in your gut
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Description:

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter and Michele Swanson

The TWiM team discusses evidence that serotonin synthesis is regulated by spore-forming members of the gut microbiota.

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode When antibiotic resistance in vitro falls short (STC) Gut microbiota control serotonin in mice (Cell) Serotonin biosynthesis (Wikipedia) Microbial endocrinology (STC) Image credit Sponsors for this episode: SciMedSolutionsJmbe.asm.orgICAAC-ICC

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

Image: Serotonin temporary tattoo by flickr user: ChezShawna

 



103. TWiM #101: The MRSA in your home
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Description:

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter and Michele Swanson

The TWiMers discuss how aroma helps disperse yeast cells on insect vectors, and evidence that MRSA is transmitted within households.

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode Aroma promotes yeast dispersal on flies (Cell Rep) MRSA is transmitted within households (mBio) FAQ: The threat of MRSA (AAM) Image credit Letters read  on TWiM 101

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

 



104. TWiM #100: Omnis cellula e cellula
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Description:

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter and Jo Handelsman.  

The TWiM team celebrates 100 episodes with a Talmudic question, and discussion of how a single mutation alters bacterial host tropism.

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode A single mutation alters bacterial tropism (Nat Gen) Talmudic question #104 (Small Things Considered) Principles of Microbial Diversity (ASM Press) Journal of Microbiology & Biology Education Letters read on TWiM 100

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

Image: Yellow colonies of S. aureus on a blood agar plate, note regions of clearing around colonies caused by lysis of red cells in the agar By: HansN. on wikimedia. From the study (Nat Gen) "...only a single naturally occurring nucleotide mutation was required and sufficient to convert a human-specific S. aureus strain into one that could infect rabbits." 



105. TWiM #99: Careers in Biodefense
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Description:

Hosts: Vincent Racaniello

Guests: Maria Julia MarinissenEdward H. You, and David R. Howell

Vincent meets up with Maria, Edward, and David at the ASM Biodefense and Emerging Infections Research meeting to talk about alternative careers for scientists.

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

 

A video version of this episode is available at microbeworld.org/twim  Links for this episode: ASM Biodefense meeting FBI Biological Countermeasures Unit Office of Policy and Planning Division of Medical Countermeasures Strategy and Requirements Division of International Health Security


Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.



106. TWiM #98: Bacteria and eukaryotes get horizontal
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Description:

 

The TWiM crew ponders the question of how a bacterium finds its middle when dividing, then divulge the transfer of interbacterial antagonism genes to eukaryotes, where they may function in innate defense.

 

Links for this episode:

 

Size independent symmetric division (Nat Commun)

How does a bacterium find its middle? (Nat Struct Biol)

Genes transferred from bacteria augment eukaryotic defenses (Cell)

Antibacterial gene transfer (eLife)

Letters read on TWiM #98 on TWiM 98

Visit microbeworld.org/twim for complete shownotes and more.



107. TWiM #97: There’s gold in them hills
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Description:

The TWiM team reveal how bacteria in a shipworm’s gills help digest wood in the gut, and an approach that identifies a new antibiotic from the soil.

 

Links for this episode:

 

Gill bacteria enable a novel digestive strategy (PNAS)

Killing bacteria without resistance (Nature)

An irresistable newcomer (Nature)

Peptidoglycan synthesis animation

10 x 20 initiative (IDSA)

Longitude Prize

Visit microbeworld.org/twim for more.



108. TWiM #96: A lean, mean sequencing machine
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Description:

Hosts: Vincent Racaniello.

Special guest: Rob Knight

Vincent meets up with Rob Knight to talk about the technology that has fueled his drive to sequence the Earth and its inhabitants.

Check out the Microbeworld app.

Links for this episode Microbes en masse (Nature) Obesity alters gut microbial ecology (PNAS) Sharing microbiome with dogs (eLife) Earth microbiome project (BMC Biology) Stability of gut micobiota (Science) Gut microbes and the brain (J Neurosci)

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.



109. TWiM #95: A microbe lover in San Diego
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Description:

Hosts: Vincent Racaniello.

Special guest: Stanley Maloy

Vincent meets up with Stan Maloy on the campus of San Diego State University to talk about his career in microbiology and his work as Dean of Science.

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.
Links for this episode:  Maloy lab Salmonella.org Microbial genetics course page Typhoid Mary

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

 



110. TWiM #94: Nitrochondria
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Description:

Vincent, Elio, and Michael discuss a symbiosis between a nitrogen-fixing cyanobacteria and a single-celled eukaryotic alga.

 

Links for this episode:

 

Unicellular cyanobacterium and alga symbiosis (Science)

Diversity of nitrogen-fixing cyanobacterium and its host (Environ Micro)

Talmudic Question #4 (answer)

Talmudic Question #2

Coccolithophore (Wikipedia)

Visit microbeworld.org/twim to view the complete shownotes and entire back catalog.



111. TWiM #93: Worming in on bacteria
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Description:

 

Vincent, Elio, and Michael reveal that a soil-dwelling nematode can recognize and respond to a bacterial quorum sensing molecule through a sensory neuron.



112. TWiM #92: Flying biofilms
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Description:

Vincent, Elio, Michael and Michele discuss the possible eradication of wild poliovirus type 3, and how microsporidian parasites prevent locust swarming behavior.

 



113. TWiM #91: Rats, viruses, and bacteria
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Description:

Vincent, Elio, and Michele review a study of the viruses and bacteria in commensal rats in New York City.

Visit microbeworld.org/twim for complete show notes. Thanks for listening!



114. TWiM #90: Think globally, act locally
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Description:

 

Vincent meets up with Laurene and David at the Annual Meeting of the Southern California Branch of the American Society for Microbiology, where they discuss how the Los Angeles County Department of Health is preparing for an outbreak of Ebola virus infection, and Cepheid’s game-changing, modular PCR system for the diagnosis of infectious diseases.



115. TWiM #89: Microbial handoffs
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Description:

Vincent, Michele, and Michael discuss how a gene from bacteria protects a tick from plant cyanide poisoning, and enhanced transmission of Streptococcus pneumoniae by influenza virus co-infection in mice.



116. TWiM #88: A century of excellence in microbiology
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Description:

Michele speaks with members of the Department of Bacteriology at the University of Wisconsin - Madison, on the occasion of its designation as a Milestones in Microbiology site, where they discuss how the department has advanced the science and teaching of microbiology.

 


117. TWiM #87: Avogadro, archaeal fossils, and ICAAC
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Description:

Vincent, Elio, and Michael explore the fossilization of archaeal lipids, and highlight the recent ICAAC in Washington, D.C.

 


118. TWiM #86: Blurring the line between organelle and endosymbiont
http://www.microbeworld.org/co... download (audio/mpeg, 49.63Mb)

Description:

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter and Michele Swanson

Vincent, Elio, Michael, and Michele consider whether our eating behavior is manipulated by gastrointestinal microbiota, and an aphid gene of bacterial origin whose gene product encodes a protein that is transported to an obligate endosymbiont. 

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode National Biosafety Stewardship month Aphid gene of bacterial origin (Curr Biol) Eroding symbiont/organelle distinction (Curr Biol) Is our eating manipulated by our microbiota? (Bioessays) Road to microbial endocrinology (STC) Microbial endocrinology (STC) Letters read on TWiM 86

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.



119. TWiM #85: Oscillation in the ocean and a Verona integron
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Description:

Vincent, Elio, Michael, and Michele discuss the diel transcriptional rythmns of bacterioplankton communities in the ocean, and extensively drug resistant Pseudomonas in Ohio.



120. TWiM #84: Microbiology Down Under
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Description:

In Melbourne, Australia Vincent speaks with David, Melanie, and Adam about their work on group A Streptococcus, Helicobacter pylori, and infections of Koalas with Chlamydia.



121. TWiM #83: Illuminating tuberculosis and cryptococcosis
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Description:

Vincent, Michael, Elio and Michele review a new fluorogenic diagnostic test for tuberculosis bacteria, and the role of a metalloprotease in helping a fungus invade the central nervous system. 

 


122. TWiM #82: Betrayal and compromise
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Description:

Hosts: Vincent RacanielloMichael SchmidtElio Schaechter and Michele Swanson.

Vincent, Michael, Elio and Michele discuss how an endosymbiont betrays its aphid host to alert plant defenses, and a new immunosuppressive cell that allows infection of neonates.

 

Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app.

Links for this episode Endosymbiont protein betrays aphid (PNAS) Plant immune system (Nature) Plant defenses against pathogens (Am Phyt Soc) New neonatal defense against infection (Nature) Marty Blaser and Bill Maher (YouTube) Two days from any village (YouTube) Letters read on TWiM 82

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.



123. TWiM #81: Cold iron is the master of them all
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Description:

Vincent, Michael, and Michele discuss how iron might disperse bacterial biofilms in carotid arterial plaques, and controlling Salmonella by modulating host iron homeostasis. 



124. TWiM #80: Hurling fleas and designer chromosomes
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Description:

Hosts: Vincent RacanielloElio Schaechter, and Michele Swanson

Vincent, Elio, and Michele discuss how to synthesize a designer yeast chromosome, and deciphering the genetic changes path that allowed Yersinia pestis to be transmitted by fleas.

Links for this episode: Total synthesis of a yeast chromosome (Science) Evolution of Y. pestis to flea-borne transmission (Cell Host Micr) Proventricular valve (Wikipedia) Image: flea with Y. pestis proventricular mass Letters read on TWiM 80

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.



125. TWiM #79: A community of microbiologists
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Description:

Vincent, Michael, and Michele review highlights of the 2014 General Meeting of the American Society for Microbiology in Boston, MA.



126. TWiM #78: A bacterium grows in Brooklyn
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Description:

Vincent, Elio, and Michael consider a fungal pathogen of insects that acquired a gene from its host that facilitates infection, and presence of gram-negative nosocomial pathogens on community surfaces near hospitals in Brooklyn. 



127. TWiM #77: Zombie plants and no pain, no gain
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Description:

Vincent, Elio, Michael, and Michelle review how a pathogen promotes plant attractiveness to insect vectors, and activation of sensory neurons that modulate pain and inflammation by bacterial infection.

 


128. TWiM #76: Genetic biopixels and a pathogenic sweet tooth
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Description:

Vincent, Elio, Michael, and Michelle discuss the use of bacteria to build a genetic sensor for heavy metals, and how host sugars help enteric pathogens to expand after antibiotic treatment.

 


129. TWiM #75: Pellicles on pickle jars
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Description:

Vincent, Elio, Michael, and Michelle discuss a symbiosis between a bacterium and fungus that increases the virulence of oral biofilms, and the assembly of amyloid fibers, which are needed for biofilm formation.

 


130. TWiM #74: It came from the Siberian permafrost
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Description:

Vincent, Elio, and Michael discuss a huge 30,000 year old virus recovered from Siberia, and nested symbiosis facilitated by horizontal gene transfer from bacteria to insect.



131. TWiM #73: Eyeing root nodule development
http://www.microbeworld.org/po... download (audio/mpeg, 54.79Mb)

Description:

Vincent, Michael, and Michele discuss how soil-dwelling bacteria induce the formation of root nodules on legumes via a protein called CYCLOPS. 



132. TWiM #72: The benefits of virulence
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Description:

Vincent, Elio, Michael, and Michele review how microbial virulence can be increased as a consequence of community surveillance and adaptation to macrophages.

 


133. TWiM #71: Colon cancer’s little shop of horrors
http://www.microbeworld.org/po... download (audio/mpeg, 54.11Mb)

Description:

Vincent, Michael, and Michele explain how the gut microbiome modulates colon tumorigenesis, and regulation of intestinal macrophage function by the microbial metabolite butyrate.



134. TWiM #70: A paroxysmal cough
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Description:

Vincent, Elio, Michael, and Michele discuss evidence that the acellular pertussis vaccine fails to prevent infection and transmission in nonhuman primates, and the use of bacterial cytological profiling to identify pathways targeted by antibiotics.



135. TWiM #69: Bacterial DNA in the human genome
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Description:

Vincent, Elio, Jo, and Michele review evidence for bacterial DNA integrated into the human genome, and control of the symbiont population in an insect midgut.




136. TWiM #68: The fungus among us
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Description:

Vincent, Elio, Michael, and Michele discuss the amazingly high level of intergenera gene exchange among haloarchaea in an Antarctic lake, and the diversity of fungi on residential surfaces and the human forehead. 



137. TWiM #67: Black mushrooms and RNA thermosensors
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Description:

Vincent, Elio, and Michael discuss how temperature triggers Neisseria menigitidis immune evasion, and protection of mice from ionizing radiation by feeding them black mushrooms.



138. TWiM #66: The shape of a container
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Description:

Vincent, Elio, Michael, and Michele discuss the curious outer membrane vesicles of Neisseria meningitides, and sources of Clostridium difficile infection revealed by genome sequencing.



139. TWiM #65: Leanness is transmissible
http://www.microbeworld.org/po... download (audio/mpeg, 35.47Mb)

Description:

Hosts: Vincent Racaniello and Michelle Swanson.

Vincent and Michelle reveal how the human gut microbiota can modulate obesity in mice.

Links for this episode:  Gut microbiota modulate metabolism (Science) 

Fighting obesity with bacteria (Science)

Letters read on TWiM 065

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.



140. TWiM #64: URI and UTI at ICAAC in Denver
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Description:

Vincent and Michael recorded this episode at the 53rd ICAAC in Denver, where they spoke with James Gern and James Johnson about rhinoviruses and extra-intestinal pathogenic E. coli.




141. TWiM #63: Superantigens, S. aureus, and the armpit microbiome
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Description:

Vincent, Michael, and Michelle discuss how a Staphylococcus aureus superantigen is critical for pathogenesis in a rabbit model, and the relationship of body odor to the axilla microbiome.



142. TWiM #62: Breaking bad and protein chain mail
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Description:

Vincent and Michael discuss how infection with influenza A virus disperses Streptococcus pneumoniae biofilms leading to disease, and an amazing protein chainmail in a viral capsid 



143. TWiM #61: The irony of probiotics
http://www.microbeworld.org/po... download (audio/mpeg, 41.27Mb)

Description:

Vincent, Elio, and Michele review how horizontal gene transfer from bacteria to an insect genome enables a tripartite nested mealybug symbiosis, and how probiotic bacteria work by competing for iron in the intestine.



144. TWiM #60: Microbial electrochemistry and diversity-generating retroelements
http://www.microbeworld.org/po... download (audio/mpeg, 49.41Mb)

Description:

Vincent, Elio, and Michael discuss how an error-prone reverse transcriptase produces enormous diversity in a Legionella protein, and using microbes to convert waste into bioelectricity and chemicals.



145. TWiM #59: Are viruses part of our immune system?
http://www.microbeworld.org/po... download (audio/mpeg, 58.63Mb)

Description:

Vincent and Michael discuss the finding that bacteriophage might be part of the mucosal antimicrobial defense system.



146. TWiM #58: The brain microbiome?
http://www.microbeworld.org/po... download (audio/mpeg, 56.33Mb)

Description:

Vincent, Elio and Michael review how underground mycelial networks carry signals that warn neighboring plants of aphid attack, and the presence of bacteria in the human brain.




147. TWiM #57: Updating the human gut microbiome to degrade seaweed
http://www.microbeworld.org/po... download (audio/mpeg, 40.55Mb)

Description:

Vincent, Elio and Michael discuss fungi that use pheromones to trap nematodes, and how genes obtained from marine bacteria help gut bacteria degrade algal carbohydrates. 



148. TWiM #56: Live at ASM in Denver
http://www.microbeworld.org/po... download (audio/mpeg, 70.21Mb)

Description:

Vincent, Elio and Michael recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Andrew, Ferric, Suzanne, and Michelle about their research on a phage system for evading innate immunity, retractions of research papers, bacterial infections of the eye, and cytoplasmic defenses against intracellular bacteria.

This episode was filmed live at ASM GM 2013 in Denver, CO. Visit www.microbeworld.org/asmlive to watch the full video archive of this episode as well as all the videos recorded during GM. 



149. TWiM #55: In the copper room
http://www.microbeworld.org/po... download (audio/mpeg, 58.49Mb)

Description:

Vincent, Elio and Michael discuss the finding that copper surfaces reduce microbial burden and hospital-acquired infections in the intensive care unit.



150. TWiM #54: Dueling injectors and the microgenderome
http://www.microbeworld.org/po... download (audio/mpeg, 50.18Mb)

Description:

Vincent, Elio, and Michael review how sex-dependent differences in the mouse microbiome regulate type I diabetes, and counterattack among bacteria.



151. TWiM #53: Live in Manchester
http://www.microbeworld.org/po... download (audio/mpeg, 41.96Mb)

Description:

Vincent, Laura, David, Kalin and Paul get together at the Society for General Microbiology meeting in Manchester, England to talk about next-generation approaches to antimicrobial therapy.



152. TWiM #52: Clinical microbiology with Ellen Jo Baron
http://www.microbeworld.org/po... download (audio/mpeg, 41.83Mb)

Description:
Vincent and Michael meet up with Ellen Jo Baron to talk about working in a clinical microbiology laboratory.


153. TWiM #51: Cave science with Hazel Barton
http://www.microbeworld.org/po... download (audio/mpeg, 36.35Mb)

Description:

Vincent, Michael, and Elio meet up with Hazel Barton to talk about cave microbiology.



154. TWiM #50: These things aren’t even bacteria!
http://www.microbeworld.org/po... download (audio/mpeg, 44.26Mb)

Description:

Vincent, Michael, and Stanley review the scientific career of Carl Woese.



155. TWiM #49: Grape-like Clusters
http://traffic.libsyn.com/twim... download (audio/mpeg, 50.94Mb)

Description:

Vincent, Michael, and Elio discuss the HIV co-receptor CCR5 as a receptor for S. aureus leukotoxin ED, and the vineyard yeast microbiome.




156. TWiM #48: It’s all about direction
http://www.microbeworld.org/po... download (audio/mpeg, 52.71Mb)

Description:

Vincent, Michael, and Jo discuss how subtle gender bias of science faculty favors male students, and the relationship of invasive infection and antibody orientation at bacterial surfaces.




157. TWiM #47: Resistance on the surface
http://www.microbeworld.org/in... download (audio/mpeg, 49.04Mb)

Description:

Horizontal transfer of antibiotic resistance genes on metal surfaces, and using bacteriophage to reverse antibiotic resistance.



158. TWiM #46: Spore!
http://www.microbeworld.org/in... download (audio/mpeg, 48.08Mb)

Description:

Vincent, Michael, and Elio meet up with Jonathan Dworkin to discuss how bacteria form spores and how they return to vegetative growth.



159. TWiM #45: Secreted nucleic acids RIG a STING
http://www.microbeworld.org/in... download (audio/mpeg, 49.68Mb)

Description:

Vincent, Michael, Elio review innate immune sensing of Listeria secreted bacterial nucleic acids, and how Wolbachia enhances egg production in Drosophila.



160. TWiM #44: Phage interruptus
http://www.microbeworld.org/in... download (audio/mpeg, 45.74Mb)

Description:

Vincent, Michael, Elio discuss the role of prophage excision in exit of Listeria from the phagosome, and analysis of bacterial communities in saliva.



161. TWiM #43: Bacterial caveolae and zapping acne with phages
http://www.microbeworld.org/in... download (audio/mpeg, 55.10Mb)

Description:

Vincent, Michael, Elio review formation of caveolae in a bacterium, and the limited genetic diversity and broad killing activity of P. acnes bacteriophages.



162. TWiM #42: Staphylococcus, a three-star pathogen
http://www.microbeworld.org/in... download (audio/mpeg, 49.56Mb)

Description:

Vincent, Michael, Elio, and Joe review highlights of the 15th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI) in Lyon, France.



163. TWiM #41: ICAAC live in San Francisco
http://www.microbeworld.org/in... download (audio/mpeg, 47.54Mb)

Description:

Vincent and Michael travel to San Francisco for the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), where they meet with Bill, John, and Victor to discuss tuberculosis, monitoring infectious disease outbreaks with online data, and outside-the-box approaches to antibacterial therapy.




164. TWiM #40: A mecca for microbiology
http://www.microbeworld.org/in... download (audio/mpeg, 42.88Mb)

Description:

**MicrobeWorld app users, click the "e" symbol in the bottom right corner of this description to watch a bonus video version of this episode!**

Vincent and Stanley meet with Waclaw Szybalski and John Kirby at Cold Spring Harbor Laboratory on the occasion of its designation as a Milestones in Microbiology site. They reminisce about how the well known laboratory has advanced the science and teaching of microbiology, and discuss John’s work on the soil dwelling, predatory myxobacteria.

If you don't have the app, please visit www.microbeworld.org/app to get more information about downloading the app for your iOS or Android device.

This video is also available for free at www.microbeworld.org in the TWiM section, epsiode #40.




165. TWiM #39: What Darwin never knew
http://www.microbeworld.org/in... download (audio/mpeg, 52.17Mb)

Description:

Vincent, Michael, and Elio reviews chapters from Microbes and Evolution, a collection of short, personal essays by microbiologists.




166. TWiM #38: The sound of whooping cough
http://www.microbeworld.org/in... download (audio/mpeg, 48.99Mb)

Description:

Vincent, Jo, Michael, and Elio review an outbreak of pertussis in Washington, and how culturing can reveal rare members of the soil biosphere.



167. TWiM #37: Microbial Jekyll and Hyde
http://www.microbeworld.org/in... download (audio/mpeg, 53.69Mb)

Description:

Vincent, Jo, Michael, and Elio discuss two examples of dynamic microbial symbioses that switch between mutualistic and pathogenic states.



168. TWiM #36: Domesticating a pathogen
http://www.microbeworld.org/in... download (audio/mpeg, 55.53Mb)

Description:

Vincent, Michael, and Elio explore the origin of Mycoplasma pathogens of ruminants, and share their thoughts on the recent ASM General Meeting.



169. TWiM #35: Ohne hauch
http://www.microbeworld.org/in... download (audio/mpeg, 48.37Mb)

Description:

Vincent, Michael, and Elio review necrotizing fasciitis, and a link between surface remodeling in gram-positive and gram-negative bacteria.



170. TWiM #34: Doing the DISCO with Emiliania
http://www.microbeworld.org/in... download (audio/mpeg, 47.59Mb)

Description:

Hosts: Vincent RacanielloMichael Schmidt, and Elio Schaechter

Vincent, Michael, and Elio discuss changing populations of Emiliania huxleyi and their viruses in the North and Black Seas.

Right click to download TWiM #34 (50 MB .mp3, 69 minutes).

Links for this episode: The protist wonderland (Microbe) Emiliania huxleyi home page DISCO in the North Sea (FEMS Microbiol Ecol) 7000 years of Emiliania huxleyi in the Black Sea (Science) Cheshire cat escape by Emiliania huxleyi (PNAS) Letters read on TWiM 34

171. TWiM #33: Tuning the immune organ
http://www.microbeworld.org/in... download (audio/mpeg, 47.32Mb)

Description:

Vincent, Michael, and Ivo review the requirement for segmented, filamentous bacteria for the induction of a specific type of helper T cell in the gut.

Links for this episode:

Induction of Th17 cells by segmented filamentous bacteria (Cell) Segmented filamentous bacteria take the stage (Nature) Genome of segmented filamentous bacteria reveals auxotrophy (Cell) Segmented filamentous bacteria and diabetes protection (PNAS)

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv , 



172. TWiM #32: Not the shadow biosphere
http://www.microbeworld.org/in... download (audio/mpeg, 46.27Mb)

Description:

Rosie Redfield talks about her evidence that a bacterium cannot grow on arsenic instead of phosphorus. 



173. TWiM 31: Screen door on a submarine
http://www.microbeworld.org/in... download (audio/mpeg, 51.93Mb)

Description:

Hosts: Vincent RacanielloJo Handelsman, and Michael Schmidt

Vincent, Jo, and Michael discuss an archetypal protein transport system in bacterial outer membranes, and evidence that gut microbial enterotypes might not fall into defined groups.

Links for this episode:

Discovery of a TAM, a new bacterial protein transport system (Nat Struct Mol Biol) Commentary on TAM discovery Enterotypes of the human gut microbiome (Nature) Gut enterotypes might be less clear-cut (Ed Yong) Letters read on TWiM #31

174. TWiM #30: Unraveling melioidosis and insulin resistance
http://www.microbeworld.org/in... download (audio/mpeg, 48.43Mb)

Description:

On episode #30 of the podcast, Vincent, Elio, and Michael review how a toxin from Burkholderia pseudomallei inhibits protein synthesis, and the role of the gut microbiome in modulating insulin resistance in mice lacking an innate immune sensor.



175. TWiM #29: Death and an iron-loaded spike
http://www.microbeworld.org/in... download (audio/mpeg, 43.45Mb)

Description:

On episode #29 of the podcast, Vincent and Stanley review how a phage pierces the cell membrane with an iron-loaded spike, and two programmed cell death systems in E. coli.



176. TWiM #28: Not unorganized bags of enzymes
http://www.microbeworld.org/in... download (audio/mpeg, 53.35Mb)

Description:

Vincent, Michael, and Elio review how competition within a host drives virulence of Streptococcus pneumoniae, and the expanding universe of the bacterial cytoskeleton.



177. TWiM #27: An inflamed gut is good for Salmonella
http://www.microbeworld.org/in... download (audio/mpeg, 51.81Mb)

Description:

Vincent, Elio, and Michael review how inflammation allows Salmonella to compete with fermenting gut microbes, and a riboswitch in bacterial and Archeal species that is triggered by fluoride.



178. TWiM #26: Suum cuique
http://www.microbeworld.org/in... download (audio/mpeg, 51.88Mb)

Description:

Vincent, Elio, and Michael discuss the finding of Sutterella species in the gut of autistic children, and methods for cultivating oral bacteria. 



179. TWiM #25: Magnetotactic bacteria and totally drug resistant TB
http://www.microbeworld.org/in... download (audio/mpeg, 53.14Mb)

Description:

On episode #25 of the podcast, Vincent, Elio, and Michael review bacteria that use the earth’s magnetic field for navigation, and identification of totally drug resistant Mycobacterium tuberculosis.



180. TWiM #24: This year in microbiology
http://www.microbeworld.org/in... download (audio/mpeg, 54.83Mb)

Description:

Vincent, Michael, and Cliff review ten compelling microbiology stories from 2011.



181. TWiM #23: Fighting antibiotics with toxic gas and starvation
http://www.microbeworld.org/in... download (audio/mpeg, 52.57Mb)

Description:

Vincent, Jo, Elio, and Michael explain how a swarming bacterium helps disperse a non-motile fungus, and bacterial antibiotic tolerance mediated by hydrogen sulfide and starvation responses.



182. TWiM #22: Microbiology 911
http://www.microbeworld.org/in... download (audio/mpeg, 45.38Mb)

Description:

Vincent and Michael speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about microbial infections encountered in the emergency room.



183. TWiM #21: Symbiotic margheritas
http://www.microbeworld.org/in... download (audio/mpeg, 47.35Mb)

Description:

Vincent and Elio discuss ancient symbiosis between Alphaproteobacteria and catenulid flatworms, and a toxin from Helicobacter pylori that engages the mitochondrial fission machinery to induce host cell death.



184. TWiM #20: Facebook for bacteria
http://www.microbeworld.org/in... download (audio/mpeg, 46.92Mb)

Description:

On episode #20 of the podcast This Week in Microbiology, Vincent, Michael, and Elio follow up on the outbreaks of E. coli in Germany and cholera in Haiti, then discuss genes that confer self-identity to Proteus mirabilis.



185. TWiM #19: Your microbiome is what you eat
http://www.microbeworld.org/in... download (audio/mpeg, 41.06Mb)

Description:

Vincent, Michael, Elio, and Jo discuss the genome sequence of Y. pestis from victims of the Black Death, and the effect of diet on gut microbial enterotypes.



186. TWiM #18: Escherichia coli K-12, an emerging pathogen?
http://www.microbeworld.org/in... download (audio/mpeg, 51.19Mb)

Description:

Vincent, Michael, Elio, and Stanley explain how to make the human intestinal commensal and benign laboratory bacterium Escherichia coli K-12 into an invasive organism, and the unearthing of century-old spores in New York City.



187. TWiM #17: Debugging endosymbiosis
http://www.microbeworld.org/in... download (audio/mpeg, 48.75Mb)

Description:

Vincent, Michael, and Elio focus on endosymbiosis: the rapid spread of Ricekttsia in whitefiles, and a metabolic patchwork in nested symbionts of mealybugs.



188. TWiM #16: ICAAC Live
http://www.microbeworld.org/in... download (audio/mpeg, 61.60Mb)

Description:

On episode #16 of the podcast This Week in Microbiology, VincentMichaelArturoStuart, and David converse about antimicrobial resistance and why most fungi do not cause disease at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).



189. TWiM #15: Microbial long distance relationships
http://www.microbeworld.org/in... download (audio/mpeg, 40.81Mb)

Description:

On episode #15 of the podcast This Week in Microbiology, Vincent, Michael and Jo review the number of species on Earth, evidence that the 2010 Haitian cholera outbreak originated in Nepal, and how gut microbiota influence the immune response to influenza virus infection of the lung. 



190. TWiM #14: Vomocytosis and microbial transistors
http://www.microbeworld.org/in... download (audio/mpeg, 46.88Mb)

Description:

On episode #14 of the podcast This Week in Microbiology, Stanley, Margaret, Michael and Elio review how the fungus Cryptococcus escapes from macrophages, and electrical conductivity in nanowires formed by the bacterium Geobacter.



191. TWiM #13: Probiotics and inflammasomes: Telling good bacteria from the bad
http://www.microbeworld.org/in... download (audio/mpeg, 39.97Mb)

Description:

On episode #13 of the podcast This Week in Microbiology, Stanley, Jo, Michael and Elio discuss how colonic microbial ecology and risk for colitis are regulated by an inflammasome, and amelioration of intestinal inflammation in mice by delivery of a probiotic-derived soluble protein to the colon.



192. TWiM #12: Photothermal nanoblades and genome engineering
http://www.microbeworld.org/in... download (audio/mpeg, 52.09Mb)

Description:

Vincent, Margaret, Michael and Elio review the use of photothermal nanoblades to dissect the Burkholderia intracellular life cycle, and manipulation of chromosomes in vivo for genome-wide codon replacement in E. coli.



193. TWiM #11: Chickens, antibiotics, and asthma
http://www.microbeworld.org/in... download (audio/mpeg, 50.22Mb)

Description:

Vincent, Margaret, Michael and Elio review the presence of extended spectrum beta-lactamase genes in chicken meat and in humans, and a beneficial effect of Helicobacter pylori colonization on the development of allergen-induced asthma.



194. TWiM #10: A symbiotic cloaking device
http://www.microbeworld.org/in... download (audio/mpeg, 47.10Mb)

Description:

On episode #10 of the podcast This Week in Microbiology, Vincent, Margaret, Elio, Michael and Dickson discuss the symbiosis between the Hawaiian bobtail squid and the luminous, gram-negative bacterium Vibrio fischeri.



195. TWiM #9: Bean sprouts and E. coli O104:H4
http://www.microbeworld.org/in... download (audio/mpeg, 52.91Mb)

Description:

Vincent, Michael, and Cliff review the outbreak of bloody diarrhea and hemolytic uremic syndrome in Germany caused by Shiga toxin-producing Escherichia coli O104:H4.



196. TWiM # 8: Live in NOLA
http://www.microbeworld.org/in... download (audio/mpeg, 59.62Mb)

Description:

Vincent, Michael, and Stanley recorded TWiM #8 live at the 2011 ASM General Meeting in New Orleans, with guests Andreas Baümler, Nicole Dubilier, and Paul Rainey. They spoke about how pathogens benefit from disease, symbioses between chemosynthetic bacteria and marine invertebrates, and repetitive sequences in bacteria.



197. TWiM #7: Cycles of life and death, light and dark
http://www.microbeworld.org/in... download (audio/mpeg, 44.37Mb)

Description:

Vincent, Cliff, Elio, Margaret, and Michael discuss programmed cell death in E. coli, and the daily synthesis and degradation of enzymes needed for photosynthesis and nitrogen fixation by cyanobacteria.



198. TWiM #6: Antibacterial therapy with bacteriophage: Reality or fiction?
http://www.microbeworld.org/in... download (audio/mpeg, 56.76Mb)

Description:

Vincent, Cliff, Michael and Elio review the use of bacteriophages to manage infections, and the presence of antibiotic resistance genes in the bacteriophage from urban sewage and river water.



199. TWiM #5: Mercury-methylating Desulfovibrio and antimicrobial nanoparticles
http://www.microbeworld.org/in... download (audio/mpeg, 52.41Mb)

Description:

Vincent, Ron, Cliff, and Michael discuss the genome sequence of a mercury-methylating bacterium and the antimicrobial effects of nanoparticles.



200. TWiM #4: Cantaloupes and Salmonella gastroenteritis
http://www.microbeworld.org/in... download (audio/mpeg, 51.66Mb)

Description:

Vincent, Cliff, Margaret, and Michael review foodborne bacterial illness in the context of outbreaks associated with cantaloupes and Lebanon bologna.



201. TWiM #3: Anthrax, genomics and the FBI inquiry
http://www.microbeworld.org/in... download (audio/mpeg, 55.34Mb)

Description:

Vincent, Jo, Cliff, and Ron explore the genome analysis done in support of the Amerithrax investigation, and an insecticidal enterotoxin-deficient mutant of Bacillus thurigiensis.



202. TWiM #2: The plague, microbial virulence and the gut microbiome
http://www.microbeworld.org/in... download (audio/mpeg, 51.98Mb)

Description:

Vincent, Cliff, and Michael review a fatal laboratory acquired Yersinia pestis infection, and how gut bacteria control body weight and metabolic activity.



203. TWiM #1: Neisseria LINEs up
http://www.microbeworld.org/in... download (audio/mpeg, 58.04Mb)

Description:

On episode #1 of the podcast This Week in Microbiology, Vincent, Cliff, Michael, and Stan discuss transfer of DNA from a human host to a bacterial pathogen, and the ability of dry copper to kill bacteria on contact.