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Podcast title This Week in Virology
Website URL http://www.microbe.tv/twiv
Description TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer, who deconstruct viruses, explain how they cause illness, and dissect the latest research.
Updated Thu, 23 Nov 2017 19:46:56 +0000
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Category Science & Medicine
Health
Education
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Episodes

1. TWiV 468: Zika by the slice
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 62.52Mb)

Description:

Amy joins the TWiV team to talk about her career and her work on Zika virus neurotropism using embryonic mouse organotypic brain slice cultures.

Hosts: Vincent Racaniello, Dickson DespommierAlan DoveRich Condit, and Kathy Spindler

Guest: Amy Rosenfeld

Become a patron of TWiV!

Links for this episode Grad students face tax hike (Nature) House voted to bankrupt grad students (NYTimes) Neurotropism of early and late Zika virus isolates (PNAS) Zika virus blocks the neuron road (virology blog) Letters read on TWiV 468

This episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm

This episode is brought to you by  the Virology and Gene Therapy PhD program at the Mayo Clinic Graduate School of Biomedical Sciences in Rochester, Minnesota. The renowned Mayo Clinic Virology and Gene Therapy program is currently accepting applications until December first. If you want to be trained in the exciting fields of oncolytic virotherapy, gene therapy, vaccine creation, or basic virology, visit mayoclinic.org to apply to the Virology and Gene Therapy program at the Mayo Clinic Graduate School of Biomedical Sciences.

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



2. TWiV 467: Jon and Ted's Excellent Adventure
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 57.61Mb)

Description:

Jon and Teddy Yewdell join the TWiV team to talk about their careers, their research, and the problems with biomedical research.

Hosts: Vincent RacanielloAlan Dove,and Rich Condit

Guest: Jon Yewdell and Teddy Yewdell

Become a patron of TWiV!

Links for this episode Jon Yewdell laboratory Chaudhuri laboratory Truth Wins by Jon Yewdell (epub or mobi download) Noncoding RNAs and class switch recombination (Int Imm) Translating DRiPs (J Leuk Biol) Lamprey VLRP response to influenza virus (eLife) The Biomedical Research Crisis (TWiV 208)

This episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



3. TWiV 466: The Capsid Club
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 37.93Mb)

Description:

From Indiana University, Vincent and Kathy speak with Tuli Mukhopadhyay, John Patton, and Adam Zlotnick about their careers and their work on alphaviruses, hepatitis B virus, and rotaviruses.

Host: Vincent Racaniello and Kathy Spindler

Guests: Tuli MukhopadhyayJohn Patton, and Adam Zlotnick

Become a patron of TWiV!

Links for this episode Mukhopadhyay lab Patton lab Zlotnick lab Tuli on Twitter Palmitoylation of Sindbis virus TF protein (J Virol) Hepatitis B virus structure (Ann Rev Virol) Rotavirus RNA polymerase (Curr Opin Virol)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



4. TWiV 465: Theodora the explorer
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 63.39Mb)

Description:

Theodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit, and Kathy Spindler

Guest: Theodora Hatziioannou

Become a patron of TWiV!

Links for this episode ASU-UofA Joint Virology Symposium Laboratory of Retrovirology, Rockefeller University HIV-1-induced AIDS in monkeys (Science) APOBEC3H bound to duplex RNA (Nat Comm) Center for HIV RNA studies Image: Two molecules of APOBEC3H bound to dsRNA

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Theodora - To Kill A Mockingbird by Harper Lee
Kathy - 25 MILLION Orbeez in a pool
Dickson - Fluid Dynamics of Paint
Rich - The Hitchhiker's Guide to the Galaxy by Douglas Adams
Alan - 30 days at sea: timelapse
Vincent - TWiEVO 24 and Every Time Zone

Listener Picks

Fernando - Lego Women of NASA

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



5. TWiV 464: Boston baked viruses
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 50.74Mb)

Description:

At Tufts University Dental School in Boston, Vincent speaks with Katya Heldwein and Sean Whelan about their careers and their work on herpesvirus structure and replication of vesicular stomatitis virus.

Host: Vincent Racaniello

Guests: Katya Heldwein and Sean Whelan

Become a patron of TWiV!

Links for this episode Crystal structure of HSV gB (Science) Crystal structure of HSV fusion regulator gH-gL (Nat Struct Mol Biol) Nuclear Exodus: Herpesviruses Lead the Way (Ann Rev Virol) VSV Pseudotypes Bearing gB, gD, gH, and gL (J Virol) Recovery of infectious VSV from cDNA clones (PNAS) Structure of the L Protein of VSV (Cell) Unique strategy for mRNA cap methylation by VSV (PNAS) Molecular architecture of VSV RNA polymerase (PNAS)

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



6. TWiV 463: We haven't meth but these names ring Nobel
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 60.03Mb)

Description:

The TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation.

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich Condit, and Kathy Spindler

Become a patron of TWiV!

Links for this episode Truth Wins by Jonathan Yewdell (epub or mobi) Gabriel Victora awarded MacArthur Prize Forty Years of mRNA Splicing (CSH) 2017 Chemistry Nobel: Jacques Dubochet, Joachim FrankRichard Henderson 2017 Physiology or Medicine Nobel: Jeffrey C. Hall, Michael Rosbash, Michael W. Young 2017 Nobel Prize in Chemistry (pdf) 2017 Nobel Prize in Physiology of Medicine (pdf) Jonathan Weiner on TWiEVO 19 RNA methylation modulates plant virus infectivity (PNAS) Letters read on TWiV 463

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy - When biospheres collide
Dickson - Blame 10 rivers for ocean plastic
Alan - Farming in The Netherlands
Vincent - Meet the Microbiologist

Listener Picks

Jay - OmegaTau podcast
Trudy - Arrowsmith by Sinclair Lewis
Mark - iOS app Human Anatomy Atlas and Master in Business podcast

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



7. TWiV Special: Tear it up with David Tuller
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 39.17Mb)

Description:

David Tuller returns to discuss his efforts to expose the methodological and ethical problems with the PACE trial for ME/CFS.

Hosts: Vincent Racaniello

Guest: David Tuller

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Links for this episode All of David's ME/CFS articles at virology blog David Tuller on Twitter Through the Shadowlands by Julie Rehmeyer

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



8. TWiV 462: Splicing RNA with Phillip A. Sharp
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 23.04Mb)

Description:

Vincent speaks with 1993 Nobel Laureate Phillip A. Sharp about his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure.

Hosts: Vincent Racaniello

Guest: Phillip A. Sharp

Become a patron of TWiV!

Links for this episode Meet the Microbiologist Sharp Laboratory Spliced segments of adenovirus late mRNA (PNAS) Video of this interview (YouTube)

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



9. TWiV 461: Gotta trace them all!
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 73.21Mb)

Description:

The TWiVers discuss the declining readability of scientific texts, and review the use of self-inactivating rabies virus for tracing neural circuits.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Brianne Barker

Become a patron of TWiV!

Links for this episode Meet the Microbiologist TWiV 1: West Nile Virus Decreasing readability of scientific texts (eLife) Measure text readability Tracing neural circuits with self-inactivating rabies virus (Cell) Cre driver network (NIH) Monosynaptic tracing with rabies virus (Neuron) Letters read on TWiV 461

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy -Best eclipse video (to date) and solargraph
Dickson - Photos by Will Eades
Brianne - Pale Rider by Laura Spinney
Rich - “Supergenes” Drive Evolution
Vincent -Anatomy of a Moral Panic

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



10. TWiV 460: Penn, a great sandbox for science
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 53.58Mb)

Description:

Vincent travels to the University of Pennsylvania and speaks with virologists Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss about their careers and their research.

Host: Vincent Racaniello

Guests: Gary Cohen, Scott Hensley, Carolina Lopez, and Susan Weiss

Become a patron of TWiV!

Links for this episode Cohen Laboratory Hensley Laboratory Lopez Laboratory Weiss Laboratory

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



11. TWiV 459: Polio turns over a new leaf
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 60.28Mb)

Description:

The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Become a patron of TWiV!

Links for this episode ASM Conference on Viral Manipulation of Nuclear Processes ASM Public Outreach Fellowship Kymriah approved (PennMed) CAR T cells (NCBI) Cost of Kymriah (NYTimes) Accidental exposure to poliovirus type 2 (Eurosurveill) GAPIII (WHO) Poliovaccine candidate in plants (Nat Commun) Vertical vaccine farm (TWiV 47) All picornaviruses, all the time (TWiV 425) Image credit Letters read on TWiV 459

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy - Cassini photos
Dickson - Caliber Biotherapeutics
Alan - Grav
Rich - Google street view of the International Space Station (article)
Vincent - the bioinformatics chat

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



12. TWiV 458: Saliva of the fittest
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 68.29Mb)

Description:

The TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Become a patron of TWiV!

Links for this episode ASM Conference on Viral Manipulation of Nuclear Processes Roger W. Hendrix, 74 (Pittsburgh Post-Gazette) Roger Hendrix video on TWiV #135 Yellow fever in traveler returning from Peru (MMWR) Dengue subgenomic RNA in mosquito salivary gland (PLoS Path) Image credit Letters read on TWiV 458

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Kathy - Antibody validation Editorial Asilomar meeting report
Dickson - Despommierphotoart.com
Alan - NOAA Hurricane Hunters
Rich - Awakenings by Oliver Sacks (encephalitis lethargica)
Vincent - Goodnight Lab by Chris Ferrie

Listener Picks

Pete - Change Agent by Daniel Suarez
Paul - Pasteur's Gambit by Stephen Dando-Collins
Maureen - Discovery Documentary First in Human

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



13. TWiV 457: The Red Queen meets the White Rabbit
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 70.94Mb)

Description:

Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Guest: Brianne Barker

Become a patron of TWiV!

Links for this episode First genetically engineered salmon sold in Canada Nucleoprotein on influenza virus RNA (Nucl Acids Res) Evolution of released myxoma virus in Australia (PNAS) Image credit Letters read on TWiV 457

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase - WITH FREE SHIPPING - by going to blueapron.com/twiv.

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Brianne - 3D printed viruses
Dickson - Secrets of Schooling
Alan - Making sails in the Nevada desert
Rich - David Vetter isolation suit (Wiki)
Vincent - Confounds the Science

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



14. TWiV 456: Be careful of canons
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 71.53Mb)

Description:

Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.

Hosts: Vincent Racaniello and Rich Condit

Guest: Brianne Barker

Become a patron of TWiV!

Links for this episode RNA pol III mutations underlie severe varicella (J Clin Inves) Dengue virus activates cGAS by release of mitochondrial DNA (Sci Rep) Dengue virus NS2B protein targets cGAS for degradation (Nat Micr) Image credit Letters read on TWiV 456

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Brianne - Up-Goer Five Challenge (related to Thing Explainer)
Rich - The Farthest: Voyager in Space and Vipassana Momma: Science
Vincent - Episode of Revisionist History: The Basement Tapes

Listener Pick

Jennie - What Piece of Lab Equipment Are You?

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



15. TWiV 455: Pork and genes
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 60.64Mb)

Description:

Erin joins the TWiVirions to discuss a computer exploit encoded in DNA, creation of pigs free of endogenous retroviruses, and mutations in the gene encoding an innate sensor of RNA in children with severe viral respiratory disease.

Hosts: Vincent RacanielloAlan Dove, Rich Condit, and Kathy Spindler

Guest: Erin Garcia

Become a patron of TWiV!

Links for this episode DNA-based computer exploit (pdf) Inactivation of porcine endogenous retrovirus in pigs (Science) Severe viral respiratory infections in children with IFIH1 mutations (PNAS) IRF7 deficiency and severe respiratory infection (TWiV 336) Image credit Letters read on TWiV 455

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Erin - What If? by Randall Monroe
Rich - Art.Science.Gallery (J. Haley Gillespie)
Kathy - Astronomy photographer of the year shortlist
Alan - Upcoming Eclipses
Vincent - Ford Thunderbird Automatic Transmission Rebuild

Listener Pick

Bryan - Neuroscientists tricks journals

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



16. TWiV 454: FGCU, Zika
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 62.22Mb)

Description:

Sharon and Scott return to TWiV for a Zika virus update, including their work on viral evolution and spread, and whether pre-existing immunity to dengue virus enhances pathogenesis.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Kathy Spindler

Guests: Sharon Isern and Scott Michael

 

Become a patron of TWiV!

Links for this episode Hurricane Zika (TWiV 410) 454 Corporation (Wikipedia) Regional Zika update, Americas (PAHO, WHO) Zika virus serum bank (pdf) Zika virus evolution and spread in the Americas (Nature) Multiple introductions of Zika virus in US (Nature) Inhibition of Zika Virus Replication by Wolbachia (J Virol) Zika virus pathogenesis in rhesus macaques unaffected by immunity to dengue virus (Nat Commun) Impact of flavivirus immunity on Zika virus infection in rhesus macaques (PLoS Path) Enhancement of Zika virus pathogenesis by antiflavivirus immunity (Science) No ADE by dengue antibodies in Zika virus patients (Clin Inf Dis) Oropharyngeal mucosal transmission of Zika virus in rhesus macaques (Nat Commun) Letters read on TWiV 454 Weekly Science Picks

Dickson - Industrial Scars
Kathy - Eclipse info by zipcode
Sharon - Michaela’s article in The Conversation
Scott - Signal P, PecaanPhameratorDNAmaster
Alan - The Eagle Whisperer” (and the Great Big Story channel)
Vincent - Bottle

Listener Pick

Kevin - Tenure track scientist bites the dust

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



17. TWiV 453: Neurovirology with Diane Griffin
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 36.99Mb)

Description:

From the Vector-Borne Viruses Symposium in Hamilton, Montana, Dickson and Vincent speak with Diane Griffin about her career and her work on understanding viral infections of the central nervous system.

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Diane Griffin

 

Become a patron of TWiV!

Links for this episode Vector-Borne Viruses Symposium Diane Griffin Adoptive immunization of immunosuppressed mice infected with Sindbis virus Role of the immune response in age-dependent resistance of mice to encephalitis due to Sindbis virus Antibody-mediated clearance of alphavirus infection from neurons Persistence of viral RNA in mouse brains after recovery from acute alphavirus encephalitis Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene Bc1-2 protects mice against fatal alphavirus encephalitis

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv.

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



18. TWiV 452: Kiss that frog
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 64.90Mb)

Description:

Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection.

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Guest: Lynda Coughlan

 

Become a patron of TWiV!

Links for this episode Linda on Virus Watch and BSGCT Anti-influenza peptide from frogs (Immunity) Magainins (Wikipedia) Urumi Kathy's defensin paper (PLoS Path) World Hepatitis Day Mouse model for hepacivirus infection (Science) Letters read on TWiV 452 Weekly Science Picks

Kathy - US rivers as subway map
Lynda - No Time to Lose: A Life in Pursuit of Deadly Viruses by Peter Piot
Alan - Apollo-era computers found in dead engineer’s basement
Vincent - 110 NFL Brains, research article in JAMA and The best science is often accidental

Listener Pick

Stig - Security Now! and The Gene by Siddhartha Mukherjee
Ricardo - John Oliver on Vaccines

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



19. TWiV 451: Expectorate the unexpected
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 59.99Mb)

Description:

The TWiV scientists reveal that mosquitoes transmit different West Nile virus populations with each blood meal, only to have the diversity purged in a bird host.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

 

Become a patron of TWiV!

Links for this episode Driving past a milestone (TWiP 100) Debug Fresno (Verily blog) What could possibly go wrong? (TWiV 388) Chestnut blight (ProMedMail) Hypovirus molecular biology (Adv Virus Res) Mosquitoes transmit unique WNV populations (Cell Rep) Teaching science using pseudoscience Image credit Letters read on TWiV 451 Weekly Science Picks

Kathy - Approaching Jupiter and Michigan parents about vaccination
Rich - Math Limericks from Futility Closet
Alan - NASA flyover of Pluto
Vincent - Talk show host nominated as USDA chief scientist

Listener Pick

Neil - These smart girls are here to debunk anti-vaxxer nonsense
John - John Sever AMA

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



20. TWiV 450: Ben tenOever and RNA out
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 55.11Mb)

Description:

Ben tenOever joins the TWiVoli to discuss the evolution of RNA interference and his lab's finding that RNAse III nucleases, needed for the maturation of cellular RNAs, are an ancient antiviral RNA recognition platform in all domains of life.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

Guest: Ben tenOever

Become a patron of TWiV!

Links for this episode RNAseIII is an ancient antiviral effector (Nature) Influenza suppression of RNAi (PNAS) Questioning mammalian antiviral RNAi (Nat Micro) Antiviral protection via RdRp (PLoS Path) Evolution of antiviral defense (Cell Host Micr) Letters read on TWiV 450 Weekly Science Picks

Ben - Invisible Invaders by Peter Radetsky
Kathy - ASV 2017 Virolympics Crossword solved (pdf) and National Museum of the Air Force
Rich - Columbia river gorge and Undaunted Courage by Stephen Ambrose
Dickson - All the World's Earthquakes
Alan - Map of Roman roads
Vincent - Brain atlas of fly behavior

Listener Pick

Rob - Vaccinate Your Kids and Charles Darwin Natural Selection
Islam - Self-assembling virus and Virus Patterns

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



21. TWiV 449: The sound of non-silencing
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 58.68Mb)

Description:

The TWiV Council explores the finding that facial appearance affects science communication, and evidence that RNA interference confers antiviral immunity in mammalian cells.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Kathy Spindler

Become a patron of TWiV!

Links for this episode JMBE SciComm Issue Facial appearance affects science communication (PNAS) Your face matters to science (virology blog) RNA based antiviral immunity in mammals (Immunity) How mice say nodavirus (TWiV 245) Press release on science meeting gender disparity The Traditional Lecture is Not Dead. I Would Know – I’m A Professor (virology blog) Sound of Silence by Disturbed (YouTube) Letters read on TWiV 449 Weekly Science Picks

Kathy - ASV 2017 Virolympics Crossword (pdf)
Dickson - The Visible Mouse
Alan - Is profitable publishing bad for science?
Vincent - Locally Sourced Science

Listener Pick

Neva - Michael Summers interview and Virus coloring book

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



22. TWiV 448: Mavis the Structure Maven
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 38.52Mb)

Description:

From ASV 2017 in Madison, Wisconsin, the complete TWiV team speaks with Mavis Agbandje-McKenna about her career and her work solving virus structures by x-ray crystallography and cryo-electron microscopy.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

Guest: Mavis Agbandje-McKenna

 

Become a patron of TWiV!

This episode of TWiV is sponsored by Promega Corporation.  Promega is a leader in providing innovative solutions and technical support to the life science industry. The company’s 3,500 products support scientists’ worldwide to advance their knowledge in genomics, proteomics, cellular analysis, drug discovery and human identification. Founded in 1978, the company is headquartered in Madison, WI with branches in 16 countries and over 50 global distributors.

Promega products are used by life scientists who are asking fundamental questions about biological processes applying their knowledge to diagnose and treat diseases or discover new therapeutics.

For more information about Promega, visit www.promega.com/ASV

Weekly Science Picks

Kathy - Doktor Kaboom!
Dickson - Mars as you've never seen it before
Alan - Eclipse 2017
Rich - Sirens of Titan by Kurt Vonnegut
Vincent - Research!America

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



23. TWiV 447: Un-impacting an elephant
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 63.33Mb)

Description:

The glorious TWiVerati un-impact their email backlog, anwering questions about viruses, viruses, viruses, viruses, viruses, and more. You should listen - our fans ask great questions!

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

Become a patron of TWiV!

Links for this episode JMBE SciComm Issue Female role models in engineering (PNAS) Gender equity at ASM meeting (mBio) Invisible Frontiers Time, Love, Memory The Eighth Day of Creation Predatory journals recruit fake editor Photo by Anthony Olszewski Letters read on TWiV 447 Weekly Science Picks

Kathy - Oskar Fischinger Google Doodle
Dickson - Ten Tiny But Terrifying Micro Monsters
Alan - Hunting mammoth ivory in Siberia
Rich - Occam’s razor
Vincent - Blame vax for illness without proof, says EU

Listener Pick

Ed - Lysenkoism

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



24. TWiV 446: Old sins die hard
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 64.67Mb)

Description:

The TWiV hosts review an analysis of gender parity trends at virology conferences, and the origin and unusual pathogenesis of the 1918 pandemic H1N1 influenza virus.

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

 

Become a patron of TWiV!

Links for this episode ASM grant writing online course Gender parity trends at virology meetings (J Virol) Professor gender perpetuates gender gap (NBER) Next generation researchers initiative (NIH) NIH abandons grant cap (Science) Genesis and pathogenesis of 1918 H1N1 influenza virus (PNAS) Image credit Letters read on TWiV 446 Weekly Science Picks

Kathy - BioKids Critter Catalog
Dickson - Shanghai Vertical Farm
Alan - Colossal Cave Adventure open source
Rich - Life on Mars (HI-SEAS)
Vincent - TWiM 154 with Arturo Casadevall

Listener Pick

Grant - Antibody validation challenges

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



25. TWiV 445: A nido virology meeting
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 36.80Mb)

Description:

From Nido2017 in Kansas City, Vincent  meets up with three virologists to talk about their careers and their work on nidoviruses.

Host: Vincent Racaniello

Guests: Margo Brinton, Luis Enjuanes, and Linda Saif

Become a patron of TWiV!

Links for this episode Murine flavivirus resistance gene (PNAS) TIA-1/TIAR binding sites in West Nile virus RNA (J Virol) Infectious coronavirus DNA in BAC (PNAS) Norovirus binding to lettuce (Appl Env Micro)

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv



26. TWiV 444: Astro Kate, The Right Stuff
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 41.02Mb)

Description:

From ASM Microbe 2017 at New Orleans, Vincent and Rich meet up with astronaut Kate Rubins to talk about becoming an astronaut, space travel, and doing science in space.

Hosts: Vincent Racaniello and Rich Condit

Guest: Kate Rubins

Become a patron of TWiV!

Links for this episode Live from the Space Station, NASA Astronaut Kate Rubins Kate Rubins (NASA, Wikipedia) Expedition 48-49 launches to the ISS Expedition 48-49 Crew Docks to the Space Station Expedition 48-49 Crew Welcomed to the Space Station Expedition 48 Crew Hands Over the Space Station to Expedition 49 Photo by Chris Condayan

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv



27. TWiV Special: Trial by Error, Continued
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 29.21Mb)

Description:

David Tuller returns to discuss the continuing saga of the UK's PACE trial for chronic fatigue syndrome, including the accusation that he is engaging in libelous blogging.

Host: Vincent Racaniello

Guest: David Tuller

 

Become a patron of TWiV!

Links for this episode TWiV 397: Trial by Error All articles by David Tuller at virology blog Getting it wrong on chronic fatigue syndrome (NY Times) Esther Crawley slide (Twitter) David's fundraising page

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



28. TWiV 443: On a leaf, no one can hear you scream
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 62.49Mb)

Description:

The TWiVsters reveal the puppet master: an RNA virus injected with wasp eggs that paralyzes the ladybug so that she protects the cocoon until the adult emerges.

Hosts: Vincent RacanielloAlan Dove, Rich Condit, and Kathy Spindler

 

Become a patron of TWiV!

Links for this episode ASM grant writing online course Who is the puppet master? (Proc Roy Soc B) Why ladybird? Ladybird ladybird Dinocampus coccinellae Image credit Letters read on TWiV 443 Weekly Science Picks

Kathy - Science Showcase Video Contest
Alan - Biochemical pathways on one chart
Rich - 35th America’s Cup
Vincent -  Viruses (pdf) and A whole new Jupiter

Listener Pick

Peter - Fake typhoid epidemic saves Polish city and Life gets complicated when disease
overruns your town
Ralph - Dilbert on climate change

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



29. TWiV 442: The New York Tim
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 67.09Mb)

Description:

Freelance science journalist Tim Requarth joins the TWiVers to explain why scientists should stop thinking that explaining science will fix  information illiteracy.

Hosts: Vincent RacanielloAlan Dove, Rich Condit, and Kathy Spindler

Guest: Tim Requarth

 

Become a patron of TWiV!

Links for this episode Neuwrite JMBE science communication issue Smallpox vaccination day The problem with facts (Fin Times) Countering antivaccination attitudes (PNAS) Effective messages in vaccine promotion (Pediatrics) Science curiosity and political information processing (Political Psychol) Teaching science using pseudoscience (D. Duncan) Letters read on TWiV 442 Weekly Science Picks

Kathy - Life Saver Lightning
Alan - Model rocket engine burning in slow-mo
Rich - scistarter
Vincent - The quest to wipe out a virus and FCC Votes to Begin Dismantling Net Neutrality

Listener Pick

Robert - Zika presentation

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



30. TWiV 441: Don't ChrY for me influenza
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 68.60Mb)

Description:

The Beacons of Viral Education (aka the TWiVoners) reveal a cost of being a male mouse - the Y chromosome regulates their susceptibility to influenza virus infection.

Hosts: Vincent RacanielloAlan Dove, Rich Condit, and Kathy Spindler

 

Become a patron of TWiV!

Links for this episode ASM Grant Writing Online Course Giant viruses not from fourth domain of life (Virology) Nuclear envelope disruption during parvovirus infection (J Virol) Nuclear deformation during SV40 infection (Nucleus) Y chromosome regulates mouse susceptibility to influenza virus (PNAS) Consomic strains (Mamm Genome) Giants among viruses (TWiV 261) Image credit Letters read on TWiV 441 Weekly Science Picks

Kathy - Social science research on “luck” in motherhood
Alan - Foiling dinghy built by engineering students (video)
Rich - Human Exploration Research Analog (HERA)
Vincent - Make measles great again in Michigan and Which tech giant would you drop?

Listener Pick

Steven - Difficult truths about a post-truth world

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



31. TWiV 440: I hardly noumeavirus
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 68.73Mb)

Description:

No problem being nice to Dickson in this episode, because he's absent for a discussion of a new giant virus that replicates in the cytoplasm yet transiently accesses the nucleus to bootstrap infection.

Hosts: Vincent RacanielloAlan Dove, Rich Condit, and Kathy Spindler

 

Become a patron of TWiV!

Links for this episode ASM Microbe Noumeavirus cytoplasmic replication depends on transient nuclear access (Nat Commun) Giants among viruses (TWiV 261) Image credit Letters read on TWiV 440 Weekly Science Picks

Kathy - U-M Rubik’s Cube story   #1 video   #2 video    #3 video
Alan - You're not going to believe this
Rich - High School student builds robot to solve Rubrik's cube
Vincent - NIH limits grant money and The abomination of a bill

Listener Pick

Ken - The Fab Lab with Crazy Aunt Lindsey
Laurel - Sally Hoskin’s CREATE program
Maureen - Simple Science Experiments You Can Do With Eggs Before Breakfast

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



32. TWiV 439: The purloined envelope
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 70.22Mb)

Description:

Paul Bieniasz joins the TWiV team to talk about the co-option, millions of years ago, of an endogenous retrovirus envelope protein by hominid ancestors for host defense against viral infection.

Hosts: Vincent RacanielloDickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Paul Bieniasz

 

Become a patron of TWiV!

Links for this episode ASM Grant Writing Online Course Bieniasz Laboratory Julius S. Youngner, 96 Distinguished virology career of Julius S. Youngner (TWiV 373) Reconstitution of a human ERV (PNAS) Co-option of ERV envelope for host defense (eLife) Letters read on TWiV 439 Weekly Science Picks

Kathy - UM Science Communication TeachOut
Alan - LLNL nuclear test videos
Rich - The Great A.I. Awakening  (Artificial neural network; DeepDream; DeepDream images)
Dickson - Cassini images
Paul - Howard Hughes Medical Institute
Vincent - Google rewrites search rankings; Senator Whitehouse on politics of climate change

Listener Pick

Anthony - Raspberry Pi 3 Model B Weather Monitor Kit

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



33. TWiV 438: Drs. TWiV go to Washington
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 59.36Mb)

Description:

 On the eve of the March for Science, the TWiV team gathers at ASM Headquarters in Washington, DC with guests Stefano and Susie to talk about the state of science communication.

Hosts: Vincent RacanielloDickson Despommier, Alan Dove, and Rich Condit

Guests: Stefano Bertuzzi and Susan Sharp

Become a patron of TWiV!

Links for this episode Journal of Microbiology & Biology Education sci comm issue ASM Cultures Stefano Bertuzzi and the scientists' big picture (Washington Post) March for Science The March for Science (NY Times) I have always marched for science (virology blog) A scientist who studies marches on the March (Atlantic) What exactly are people marching for (Atlantic) Explaining science won't fix information illiteracy Letters read on TWiV 438

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Weekly Science Picks

Alan - Steve Ballmer’s government data project (NYTimes article)
Rich - Alexander Hamilton by Ron Chernow
Dickson - Shanghai vertical farming
Vincent - Right-to-try sham and NASA media
Stefano - Why Religion is Natural and Science is Not and The Path Between the Seas
Susan - Rick and Morty

Listener Pick

Johnye - A capella CRISPR/Cas9

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



34. TWiV 437: Kathy's new spindle virus
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 60.13Mb)

Description:

The TWiVsters reveal new giant viruses that argue against a fourth domain of life, and discovery of viruses in the oceanic basement.

Hosts: Vincent RacanielloDickson DespommierRich Condit, and Kathy Spindler

 

Become a patron of TWiV!

Links for this episode Journal of Microbiology & Biology Education sci comm issue Mark Wainberg dies Giant viruses with many translation system components (Science) Viruses in the oceanic basement (mBio) 2-back test Photo by Judy Letters read on TWiV 437

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Weekly Science Picks

Kathy - Cloud appreciation society
Rich - High Rise Urban Farming
Dickson - Planets orbiting a distant star
Vincent - TWiEVO 18: Raiders of the lost orco

Listener Pick

Kevin - Cherry blossoms at Brooklyn Botanical Garden

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



35. TWiV 436: Virology above Cayuga's waters
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 67.74Mb)

Description:

Host: Vincent Racaniello

Guests: Susan Daniel, Colin Parrish, and Gary Whittaker

At Cornell University in Ithaca, New York, Vincent speaks with Susan, Colin, and Gary about the work of their laboratories on parvoviruses, influenza viruses, and coronaviruses that infect dogs, cats, horses and other mammals.

 

Become a patron of TWiV!

Links for this episode Daniel Laboratory Parrish Laboratory Whittaker Laboratory

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



36. TWiV 435: Two virus particles walk into a cell
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 69.47Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

The TWiVome discuss the blood virome of 8,420 humans, and thoroughly geek out on a paper about the number of parental viruses in a plaque.

 

Become a patron of TWiV!

Links for this episode ASM Grant Writing Course Screwworm letters Blood DNA virome of 8,240 humans (PLoS Path) Plaque co-infection frequencies (mBio) Ode to a plaque (TWiV 68) Counting viruses (Virus Watch) First animal virus plaque assay (J Exp Med) Letters read on TWiV 435

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Weekly Science Picks

Alan - Couple donates insect collection
Kathy - Why is science important to you?
Rich - Hook
Dickson - Ten Incredible Astronomy Pictures
Vincent - Why Trump’s NIH Cuts Should Worry Us and
The Real Threat to National Security: Deadly Disease 

 Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



37. TWiV 434: Live long and pupate
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 60.87Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

The esteemed TWiVumvirate reveal the discovery of a new negative stranded RNA virus of wasps that regulates longevity and sex ratio of its parasitoid host.

 

Become a patron of TWiV!

Links for this episode ASM Microbe 2017 Parasitoid wasp virus regulates sex ratio (PLoS Path) What is a contig? Image credit Letters read on TWiV 434

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Weekly Science Picks

Alan - The Wrath of Khan from Bug Chicks
Kathy - Boaty McBoatface submarine launching
Dickson - Fierce animal portraits
Vincent - Westworld

Listener Picks

Hannah - Plague, Inc
Stig - John Oliver: Trump vs the truth

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



38. TWiV 433: Poops viruses and worms
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 61.69Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

The lovely TWiV team explore evolution of our fecal virome, and the antiviral RNA interference response in the nematode C. elegans. 

Become a patron of TWiV!

Links for this episode ASM Clinical Virology Symposium Evolution of the human fecal virome (PNAS) Antiviral RNAi response in C. elegans (Curr Biol) Orsay virus (TWiV 123) Broad VSV host range (J Comp Neurol) Image credit Letters read on TWiV 433

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Weekly Science Picks

Alan - Contact information for Senators and Representatives
Kathy - How Tumor Virology Transformed Oncology
Dickson - Seven new species of Peacock Spider
Vincent - Proposed NIH budget cut and Expensive Oxford Comma

Listener Pick

Kim - Pigeon Fashion Week (TWiEVO 7)
Richard - aeroMorph and Understanding Molecular Evolution
Johnye - Ice Instruments and Fahrenheit and Celsius

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



39. TWiV 432: Conjunction junction, what's your function?
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 62.22Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

The TWiVites discuss Zika virus seroprevalence in wild monkeys, Zika virus mRNA vaccines, and a gamete fusion protein inherited from viruses.

Become a patron of TWiV!

Links for this episode Nido2017 Meeting ASMCUE Seroprevalence of Zika virus in wild monkeys and baboons (mSphere) Zika virus mRNA vaccines (paper onepaper two) Gamete fusion protein is type II viral fusogen (paper onepaper two) Image credit Letters read on TWiV 432

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Weekly Science Picks

Alan - Raspberry pi
Kathy - The Worst F&#%ing Words Ever
Dickson - NASA images of climate change
Brianne - How herd immunity works
Vincent - Radioactive boars in Fukushima

Listener Pick

Margaret - DNA socks and gloves

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



40. TWiV 431: Niemann-Pick of the weak
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 68.06Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak.

 

Become a patron of TWiV!

Links for this episode Nido2017 Meeting ASM Microbe 2017 Mark Buller obituary RS virus pipeline (pdf) Prophage WO genes and cytoplasmic incompatibility (Nature) Vanderbilt Virology (TWiV 332) Basis for increased Ebolavirus glycoprotein activity (Cell Host Micr) Letters read on TWiV 431

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Weekly Science Picks

Rich - Germ Theory by Robert P. Gaynes
Alan - Student Scientist Partnerships
Kathy - Symbiartic
Dickson - PaleoBioDB Navigator
Vincent - Kusama Infinity Room

Listener Pick

Chaim - How to fight back against the backfire effect

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



41. TWiV 430: The persistence of herpesvirus
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 60.13Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierRich Condit, and Kathy Spindler

The TWiX cabal discuss sexual transmission of Zika virus in mice, and how immune escape enables herpes simplex virus escape from latency.

 

Become a patron of TWiV!

Links for this episode Nido2017 Meeting ASM Clinical Virology Symposium Zika virus sexual transmission in mice (Cell Rep) Viral RNA is not infectious virus (virology blog) Methyl-phospho switch (TWiV 369) Immune escape of herpesvirus from latency (Cell Rep) Restarting lytic gene expression (J Virol) Letters read on TWiV 430

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Weekly Science Picks

Rich - Vipassana Momma (Dravet Syndrome)
Kathy - Landlines Chrome Experiments
Dickson - Origami Revolution
Vincent - Hunched Over a Microscope

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv



42. TWiV 429: Zika Experimental Science Team
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 46.66Mb)

Description:

Host: Vincent Racaniello

Guests: Katie Antony, Tom Friedrich, Emma Mohr, and David O'Connor

Vincent meets with members of team ZEST at the University of Wisconsin Madison to discuss their macaque model for Zika virus pathogenesis.

 

Become a patron of TWiV!

Links for this episode Badgers Go Viral (TWiV 260) Rhesus macaque model of Zika virus infection (Nat Commun) Heterologous Zika virus protection in macaques (PLoS NTD) ZEST Data Portal

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv

Send your virology questions and comments to twiv@microbe.tv



43. TWiV 428: Lyse globally, protect locally
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 62.03Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVsters explain how superspreader bacteriophages release intact DNA from infected cells, and the role of astrocytes in protecting the cerebellum from virus infection.

 

Become a patron of TWiV!

Links for this episode Nido2017 Meeting Superspreader bacteriophages (mBio) Astrocytes, interferon, and viral infection (JCI) Viral disruption of blood brain barrier (Trends Micro) On Warts by Lewis Thomas (pdf) Letters read on TWiV 428

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv

Weekly Science Picks

Alan - Skulls Unlimited
Rich - Bernard Moss Reflection
Kathy - Why vaccines don't cause autism
Dickson - Honomobo
Vincent - Trump vs FDA

Send your virology questions and comments to twiv@microbe.tv



44. TWiV Special: Vincent Munster on MERS-coronavirus and Ebolavirus
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 32.53Mb)

Description:

Guest: Vincent Munster

At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Vincent Munster about the work of his laboratory on MERS-coronavirus and Ebolaviruses.

 

Become a patron of TWiV!

Links for this episode Rocky Mountain Laboratory Munster Laboratory Small town, big science (TWiM 140) Image credit

Send your virology questions and comments to twiv@microbe.tv



45. TWiV 427: It was a DURC and UV light
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 56.54Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

The TWiVoids discuss the March for Science, the GOF moratorium, and a classic virology paper on mapping the gene order for vesicular stomatitis virus.

 

Become a patron of TWiV!

Links for this episode ASM 2017 election is now open - VOTE HERE ASM Election questions: Which positions are we voting for? What is the ASM Board of Directors? Organization Chart What is the Council on Microbial Sciences? Organization Chart FAQs Scientists' march is bad idea (NY Times) GOF moratorium lifted (Archived White House) VSV gene order (PNAS) VSV gene order later (PNAS) Letters read on TWiV 427

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv

Weekly Science Picks

Alan - Good Omen miniseries (book)
Kathy - How to cure earworms
Dickson - Exoplanets orbits
Vincent - Outbreak News Today

Listener Pick

Tom - The Smartest Protester

Send your virology questions and comments to twiv@microbe.tv



46. TWiV 426: I'm Axl, and I'll be your cervid today
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 63.20Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells.

 

Become a patron of TWiV!

Links for this episode Register for ASV 2017 ASM 2017 election is now open - VOTE HERE ASM Election questions: Which positions are we voting for? What is the ASM Board of Directors? Organization Chart What is the Council on Microbial Sciences? Organization Chart FAQs Scientists March on Washington Spontaneous generation of unique cervid strain (mSphere) Zika virus entry into human glial cells via Axl (Cell Rep) Article collections: PNASCellNatureVirology Letters read on TWiV 426

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv.

Weekly Science Picks

Alan - Deerland by Al Cambronne
Dickson - Antarctica's Colorful Underwater World
Kathy - You can’t unring a bell #1 and #2
Rich - Extra letters added to life's genetic code (source) and The Doomsday Clock (wiki)
Vincent - Trump Science AdvisorsNational Parks Won't Be Silenced

Listener Pick

Stefan - The Vital Question by Nick Lane
Kevin - Scientists March on Washington?
Dennis - Fractal Tree of Life

Send your virology questions and comments to twiv@microbe.tv



47. TWiV 425: All picornaviruses, all the time
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 61.79Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVaniellos discuss a thermostable poliovirus empty capsid vaccine, and two cell genes that act as a switch between entry and clearance of picornavirus infection.

 

Become a patron of TWiV!

Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens XKCD #242 Thermostable poliovirus empty capsid vaccine (PLoS Path) Switch between viral entry and clearance (Nature) Glass poliovirus by Jason Roberts Letters read on TWiV 425

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv.

Weekly Science Picks

Alan - Medical lab whirligig
Dickson - Antarctica's Colorful Underwater World
Kathy - Prince Rupert’s drops #1 and #2
Rich - Dylan's 30th - Eric Clapton --Don’t Think Twice, It’s All Right  (The 30th Anniversary Concert Celebration)
Vincent - Saving climate data and Public Good and Public Funding of Science

Listener Pick

Suellen - For the anti-vaccine people

Send your virology questions and comments to twiv@microbe.tv



48. TWiV 424: FLERVergnügen
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 64.21Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

Guest: Trudy Rey

Trudy joins the the TWiVlords to discuss new tests for detecting prions in the blood, and evidence showing that foamy retroviruses originated in the seas with their jawed vertebrate hosts at least 450 million years ago.

 

Become a patron of TWiV!

Links for this episode Welcome omega tau to MicrobeTV Register for ASV 2017 Oliver Smithies dies Assays for prions in the blood (onetwo) Biosafety working on prions (Michigan State) Marine origin of retroviruses in Palaeozoic era (Nature Comm) Cancer Virus by Dorothy Crawford Adenovirus and obesity (Int J Chronic Dis) Image credit Letters read on TWiV 424 Weekly Science Picks

Trudy - Artist Jenni Viljaniemi
Alan - Radio Garden
Dickson - World's First Green Energy Boat
Kathy - mSphereDirect video and web
Rich - Deathworld Trilogy by Harry Harrison
Vincent - Trump's Vaccine Panel (NYTimes), Offit's Response (Daily Beast), ASM Letter

Send your virology questions and comments to twiv@microbe.tv



49. TWiV 423: Dry, well formed, and light brown
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 63.16Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

Guest: Jared Rice

The TWiV academia discuss induction of diarrhea by the capsid protein of an astrovirus, and association of a fungal RNA virus with white-nose syndrome of North American bats.

 

Become a patron of TWiV!

Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Astrovirus capsid protein induces diarrhea (mBio) Fungal virus associated with white-nose syndrome (PLoS Path) Image credit Letters read on TWiV 423 Weekly Science Picks

Alan - GPS visualizer
Dickson - James Webb Space Telescope and The Vertical Farm
Kathy - First Snowflake Photos (One and Two)
Rich - Red Mars by Kim Stanley Robinson
Vincent - Carrie Fisher Fought for the Rebel Alliance and Mental Health Awareness

Listener Pick

Ken - The Abate Lab
Sean - The Death of Expertise

Send your virology questions and comments to twiv@microbe.tv



50. TWiV 422: Watching the icosahedron drop
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 67.30Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVestigators wrap up 2016 with a discussion of the year's ten compelling virology stories.

 

Become a patron of TWiV!

Should auld infections be forgot
And never T-cells primed?
Will cross-reacting antigens
Protect the host next time?

Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Ten virology stories from 2016 Zika virus (first covered in 2015, TWiV 368) Ebolavirus Eukaryotic genes in Wolbachia phage (TWiV 412) Harold "400" Varmus (TWiV 400) and many other guests Vaccines Mutualism Mosquitoes and viruses Vector victorious (TWiV 401) Animal models of virus infections Virus evolution Current Zika virus infections (ECDC) Early Zika virus infections in Hawaii (PLoS NTD) Zika virus vaccine for whom? (NYTimes) Final results for Ebola virus vaccine (Lancet) Photo from Mohammad Letters read on TWiV 422

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan - North America's Lost Medieval City
Dickson - New Views of Pillars of Creation
Kathy - Reilly Top Ten
Rich - Everyday Einstein
Vincent - Naples' Sleeping Volcano Might Be Waking Up

Listener Pick

John - RadioLab: The Times They Are a-Changin'

Send your virology questions and comments to twiv@microbe.tv



51. TWiV 421: Like flies on shot
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 64.32Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

Guest: Nathan Letts

The TWiVnauts present another example of an infectious but replication incompetent vaccine, an insect specific arborvirus bearing chikungunya virus structural proteins.

 

Become a patron of TWiV!

Links for this episode Register for ASV 2017 ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens Chikungunya virus vaccine using insect virus platform (Nat Med) Ebola vaccine results (NYTimespaper) Letters read on TWiV 421

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan - Open Access Button
Dickson - National Geographic Photographs
Kathy - World's Tiniest Radio Receiver
Nathan - Mutter Museum, Philadelphia
Vincent - How Rogue One is Connected to the Mac

Listener Pick

Sam - Cell Lab: Evolution Sandbox
Hannelore - Congressional Dish
Johnye - The Fungi in Your Future
Brendan - Zimmer on Longform podcast

Send your virology questions and comments to twiv@microbe.tv



52. TWiV 420: Orthogonal vectors
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 66.69Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines.

 

Become a patron of TWiV!

Links for this episode Register for ASV 2017 Local Zika virus transmission in Texas Texaszika.org Local dengue virus transmission in Texas (EID) No more Zika virus transmission in Florida (FL DOH) Dengue virus antibodies enhance Zika virus infection (Clin Trans Imm) Infectious, replication incompetent influenza virus vaccine (Science) Pyrrolysl-tRNA synthetase (Biochem Biophys Acta) History of nonsense suppression (Stan Maloy) Suppression of poliovirus amber mutant (Cell) Remembering mumps (PLoS Path) Letters read on TWiV 420

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan - Superbugs game
Dickson - Dinosaur tail trapped in amber
Rich - Earth's Rotation is Slowing (original article)
Kathy - Lithium Ion batteries (one and two)
Vincent - Truth and Lies in the Age of Trump (virology blog) and self driving Uber car

Listener Pick

Steve - New York City Street Tree Map
Justin - Transmissible vaccines?

Send your virology questions and comments to twiv@microbe.tv



53. TWiV 419: The selfless gene
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 60.58Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVrific gang reveal how integration of a virophage into the nuclear genome of a marine protozoan enhances host survival after infection with a giant virus.

 

Become a patron of TWiV!

Links for this episode Microcephaly associated with Zika virus infection in Colombia (MMWR) Virophage genome integration and activation by superinfection (Nature) Don Nelson interview (pdf) Page view and h index for paper rank (PLoS One) Credit for image of C. roenbergensis Letters read on TWiV 419

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan - Lab Wars
Dickson - Star in a Jar Fusion Reactor
Rich -You're a Bee. This is What it Feels Like.
Kathy - List of Potential Predatory Journals
Vincent - CRISPR Patent Trial Begins

Listener Pick

Drake - Spinzall
Katreya - Periodic Videos
Pritesh - Smallpox in mummy

Send your virology questions and comments to twiv@microbe.tv



54. TWiV 418: Of mice and MERS
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 60.01Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVsters describe a new animal model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the mouse gene encoding an ortholog of the virus receptor.

Become a patron of TWiV!

Links for this episode New mouse model for MERS (Nat Micro) RNA-guided genome engineering (Science) Photo by Finny Letters read on TWiV 418

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 27:50

This show is sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. This Holiday season give someone a Drobo to keep all their files and memories safe forever. TWiV listeners can save 20% or more off of their purchase of a Drobo 5D, Drobo 5Dt, Drobo 5N, or any 8-drive or 12-drive system at www.drobostore.com by December 31, 2016 using discount code MICROBE20. 

Register for ASV 2017 at Madison, Wisconsin

Weekly Science Picks

Alan - Human population through time
Dickson - Every Orbit Cassini Has Taken
Rich - OK GO: Walk Her Walk
Kathy - Medieval Bestiary Online
Vincent - Can You Out-Science an Eighth Grader? and Stitchen Pox

Listener Pick

Hannah - Bioart and Bacteria

Send your virology questions and comments to twiv@microbe.tv



55. TWiV Special: Gary Nabel on World AIDS Day 2016
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 24.15Mb)

Description:

Host: Vincent Racaniello

Guest: Gary Nabel

Vincent speaks with Gary Nabel, Chief Scientific Officer at Sanofi and former Director of the Vaccine Research Institute of NIAID, about his career and his work on HIV vaccines.

 

Become a patron of TWiV!

Links for this episode World AIDS Day Video of this interview (YouTube)

Send your virology questions and comments to twiv@microbe.tv



56. TWiV 417: O is the loneliest letter
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 63.71Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The Fellowship of the Virus trace the early history of HIV in North America, based on genome sequences obtained from late 1970s archival sera, which also reveal that Gaetan Dugas was not Patient Zero.

 

Become a patron of TWiV!

Links for this episode WHO: Zika virus is no longer a PHEIC World AIDS Day Early HIV/AIDS history in North America (Nature) Dugas was not AIDS patient zero (virology blog) Image credit Letters read on TWiV 417

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm

Register for the 2017 ASM Grant Writing Online course.

Weekly Science Picks

Alan - VP8SGI
Dickson - 
New leaf-shaped spider discovered
Rich - 
Dance of Earth and Venus About the Sun
Kathy - Cultivar SeriesMutatoesUli Westphal site
Vincent - 
Kung Fu Mantis vs Jumping Spider

Send your virology questions and comments to twiv@microbe.tv



57. TWiV 416: Scattered seeds dormant
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 73.02Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The multi-dimensional TWiV-brane bring you the entries in the haiku/limerick contest, and explain how a giant virus infects a host within another host (it has to do with predators!).

Become a patron of TWiV!

Links for this episode Predators allow virus infection of endosymbiont (PNAS) Image credit Letters read on TWiV 416

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:34:40

Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 5:05

Register for the 2017 ASM Grant Writing Online course.

Weekly Science Picks

Alan - Cubes in Space
Dickson - 
The Architecture of Eden by H. Pearlman and A. Whalley
Rich - 
Studying the building blocks of life in stereo (original paper)
Kathy - Ancient bottom wipes yield evidence of diseases (original paper)
Vincent - 
Iguana vs snakes

Send your virology questions and comments to twiv@microbe.tv



58. TWiV 415: Ebola pipettors and the philosopher's clone
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 63.45Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Guests: Jeremy LubanAaron Lin, and Ted Diehl

Jeremy, Aaron, and Ted join the TWiV team to discuss their work on identifying a single amino acid change in the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells.

 

Become a patron of TWiV!

Links for this episode Ebola virus glycoprotein with increased infectivity (Cell) Effect in cells of Ebola virus mutations from West African outbreak (Cell) Ebola virus in semen for over 500 days (Clin Inf Dis) Puzzling origin of 2014 Ebola virus outbreak (J Virol) Mutant Ebola virus may have caused explosive outbreak (Goats and Soda) Virus Genomics and Evolution website

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:05:40

Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 1:35

Register for the 2017 ASM Grant Writing Online course.

Weekly Science Picks

Jeremy – Real time tracking of Ebola virus evolution
Ted - The Brain Scoop
Aaron - Kate Rubins sequencing DNA on ISS (video)
Alan – A Sand County Almanac by Aldo Leopold
Rich –  Vendee Globe
Kathy – Axios
Vincent – Vendors from above by Loes Heerinck

Send your virology questions and comments to twiv@microbe.tv



59. TWiV 414: Zika in the guys with Diamond
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 47.90Mb)

Description:

Host: Vincent Racaniello

Guest: Michael Diamond

Michael Diamond visits the TWiV studio to talk about chikungunya virus and his laboratory's work on a mouse model of Zika virus, including the recent finding of testicular damage caused by viral replication.

 

Become a patron of TWiV!

Links for this episode Chikungunya virus chronic joint disease caused by adaptive response (J Virol) Mouse model of Zika virus pathogenesis (Cell Host Micr) Zika virus infection during mouse pregnancy (Cell) Zika virus infection damages mouse testes (Nature) Uveitis and Zika virus in tears in mice (Cell Rep)

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm

Register for the 2017 ASM Scientific Writing and Publishing Online Course.

Send your virology questions and comments to twiv@microbe.tv



60. TWiV 413: Partnerships not parachutes
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 41.49Mb)

Description:

Hosts: Vincent Racaniello, Alan Dove, and Paul Duprex

Guests: Ralph BaricFelix DrexlerMarion Koopmans, and Stacey Schultz-Cherry

From the EIDA2Z conference at Boston University, Vincent, Alan and Paul meet up with Ralph Baric, Felix Drexler, Marion Koopmans, Stacey Schultz-Cherry to talk about discovering, understanding, protecting, and collaborating on emerging infectious diseases.

 

Become a patron of TWiV!

Links for this episode EIDA2Z meeting MERS-CoV infection of Alpaca (EID) Origins of HAV in small mammals (PNAS) WHO recommendations on influenza vaccine composition Collaborative Cross mice Video of this episode at YouTube

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm

Send your virology questions and comments to twiv@microbe.tv



61. TWiV 412: WO, open the borders and rig the infection
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 69.84Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Guest: Mark Fuccio

The TWiVome reveal the first eukaryotic genes found in a bacteriophage of Wolbachia, and how DNA tumor virus oncogenes antagonize sensing of cytoplasmic DNA by the cell.

 

Become a patron of TWiV!

Links for this episode Zika virus in vaginal secretions (EID) Zika virus in semen (EID) Eukaryotic genes in a bacteriophage (Nat Commun) Seth Bordenstein on TWiV 332 DNA tumor virus oncogenes antagonize cGAS-STING (Science) Letters read on TWiV 412

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Weekly Science Picks

Mark - EFN Enterprise Futures Network and Mission Log Podcast
Alan - 2016 Wildlife Comedy Photography
Rich -  ZuTA, portable robotic printer
Kathy - How LEGO help blind people see
Vincent - Airplane photos of Mike Kelley

Listener Pick

Hannah - Frozen Flow Glass (Instagram)

Send your virology questions and comments to twiv@microbe.tv



62. TWiV 411: Chicken runs
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 55.88Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

The TWiVeroos examine a reverse spillover of Newcastle disease virus vaccines into wild birds, and identification of a protein cell receptor for murine noroviruses.

 

Become a patron of TWiV!

Links for this episode MicrobeTV Store Florida DOH Daily Zika Update Zika virus in new Miami neighborhood (CNNNYTimes) NDV vaccine virus in wild birds (PLoS One) Protein cell receptor for murine norovirus (SciencePNAS) Poliovirus receptor analysis (J Virol) Letters read on TWiV 411

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Weekly Science Picks

Alan - Braincraft
Rich -  Now is the Greatest Time to Be Alive
Kathy - CRISPR/Cas9 by A Capella Science
Vincent - Microbes After Hours: The Necromicrobiome

Listener Pick

Jolene - Chalk Talk Science by Dennis Mangan

Send your virology questions and comments to twiv@microbe.tv



63. TWiV 410: Hurricane Zika
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 69.47Mb)

Description:

Guests: Sharon Isern and Scott Michael

Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami.

 

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Links for this episode Live at Florida Gulf Coast University (TWiV #111) Florida DOH Daily Zika Update Regional Zika update, Americas (PAHO, WHO) NJ Zika Bill Dengue virus antibodies enhance Zika virus infection (bioRxiv) First detection of Zika virus in Brazilian A. aegyptii (Mem Inst Oswaldo Cruz) 2017 ASM Scientific Writing and Publishing Online Course Letters read on TWiV 410

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Weekly Science Picks

Sharon - Zika virus comics and cartoons and Florida weekly arbovirus reports
Scott - Real-time tracking of Zika virus evolution
Alan - Evolution of antibiotic resistance on a mega plate
Rich -  Windytv
Kathy - Zika virus map and timeline
Vincent - Ohsumi Nobel advanced information and HR 5325 funding breakdown

Send your virology questions and comments to twiv@microbe.tv



64. TWiV 409: A Nef is enough
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 71.67Mb)

Description:

Guest: Jeremy Luban

Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles.

 

Become a patron of TWiV!

Links for this episode No recovery in PACE trial (virology blog) The real PACE data (virology blog) Contagious Thinking Florida DOH daily Zika update Congress does not fail on Zika (NPR) Nef history (Luban lab) Nef excludes SERINC from virions (Nature) SERINC counters Nef (Nature) ASM Grant Writing Online Course Letters read on TWiV 409

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 28:50

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Weekly Science Picks

Alan - Migration in Motion
Dickson - Beautiful Chemistry
Rich - XKCD Timeline of Earth Temperature
Kathy -  Vaccine Heroes from Vaccine Education Center
Jeremy - CIDRAP posters and Demon in the Freezer
Vincent - People Peas and Pathogens

Listener Picks

Matlock - Science isn't broken

Send your virology questions and comments to twiv@microbe.tv



65. TWiV 408: Boston Quammens
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 40.10Mb)

Description:

Hosts: Vincent Racaniello and Alan Dove

Guest: David Quammen

Four years after filming 'Threading the NEIDL', Vincent and Alan return to the National Emerging Infectious Diseases Laboratory BSL4 facility at Boston University where they speak with science writer David Quammen.

 

Watch this episode at YouTube

Become a patron of TWiV!

Links for this episode David Quammen's website Spillover by David Quammen Threading the NEIDL (TWiV 200) The NEIDL at Boston University

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your virology questions and comments to twiv@microbe.tv



66. TWiV 407: Tar Heels go viral, part two
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 47.90Mb)

Description:

Host: Vincent Racaniello

Guests: Ralph BaricKristina De ParisTal KafriHelen LazearMark Heise, and David Margolis

In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists.

 

View video of this episode at YouTube

Become a patron of TWiV!

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your virology questions and comments to twiv@microbe.tv



67. TWiV 407: Tar Heels go viral, part one
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 41.26Mb)

Description:

Host: Vincent Racaniello

Guests: Dirk DittmerCary MoodyNat MoormanNancy Raab-TraubLishan Su, and Jennifer Webster-Cyriaque

In the first of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on DNA viruses, and what they would be doing if they were not scientists.

View video of this episode at YouTube

 

Become a patron of TWiV!

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your virology questions and comments to twiv@microbe.tv



68. TWiV 406: Pow, right in the enteroids!
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 56.33Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiV team discussed eye infections caused by Zika virus, failure of Culex mosquitoes to transmit the virus, and replication of norovirus in stem cell derived enteroids.

 

Become a patron of TWiV!

Links for this episode Florida DOH daily Zika update Congress fails again on Zika (NY Times) Culex pipiens does not support Zika virus replication (EID) Zika virus in the eye (Cell Rep) Norovirus replication in enteroids (Science) Norovirus replication in B cells (TWiV 312) Baylor press release Norovirus replication in B cells confirmed (Antiviral Res) Letters read on TWiV 406

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Weekly Science Picks

Alan - Infective Perspective
Dickson - The Living River
Rich - Freddy Mercury around the Sun
Kathy -  A Day in Pompeii
Vincent - Spraying Pesticides

Listener Picks

Ricardo - Why the metric system matters
Eric - The Giving Plague by David Brin

Send your virology questions and comments to twiv@microbe.tv



69. TWiV 405: All the world's a phage
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 67.16Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

The TWiXers discuss a study on vertical transmission of Zika virus by Aedes mosquitoes, and uncovering Earth's virome by mining existing metagenomic sequence data.

 

Become a patron of TWiV!

Links for this episode Roger Tsien, 64 (UC San Diego Health) CDC running out of Zika money (NYTimes) Zika virus in Miami mosquitoes (NYTimes) No Zika virus in Rio Olympics (NYTimes) Vertical transmission of Zika virus in Aedes aegypti (AJTMH) Uncovering Earth's virome (Nature) Image credit (Global water volume) Letters read on TWiV 405

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 58:55

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Weekly Science Picks

Alan - The Vizzies
Dickson - NASA Spinoff
Kathy -  Maps.me
Vincent - Zika: The Emerging Epidemic by Donald McNeil

Listener Picks

Tarwin - Darwin's Radio by Greg Bear (paper or Kindle)
Bodham - The start of scientific publishing, 1665

Send your virology questions and comments to twiv@microbe.tv



70. TWiV 404: Not found
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 87.08Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Rich Condit

From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes.

 

Become a patron of TWiV!

Links for this episode FluMist problem (FDA) DA Henderson obituary (NY Times) DA Henderson, smallpox eradicator (TWiV Special) Efficacy of VZV vaccine (Ther Adv Vaccines) Zika virus burden, Puerto Rico (JAMA) Zika virus in Miami Beach (STAT) Congenital brain anomalies and Zika virus (Radiology) Congenital Zika syndrome with arthrogryposis (BMJ) Multicomponent animal virus from mosquitoes (Cell Host Microbe) Breaking rules of infection (NPR) Image credit Letters read on TWiV 404

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Weekly Science Picks

Alan - Sally Le Page
Dickson - Comfortably Numb by Jamie Dupuis
Rich -  Learned Helplessness
Vincent - Virus by Marilyn Roossinck

Listener Picks

OneTime - The Stranglers - Old Codger
Steve - A Poem About Pronunciation

Send your virology questions and comments to twiv@microbe.tv



71. TWiV Special: DA Henderson, smallpox eradicator
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 31.48Mb)

Description:

Donald “D.A.” Henderson, a physician, educator, and epidemiologist who led the World Health Organization’s campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox eradication effort, and what it means for the eradication of polio. 

Become a patron of TWiV!

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your virology questions and comments to twiv@microbe.tv



72. TWiV 403: It's not easy being vaccine
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 66.62Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Rich Condit

The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine.

 

Become a patron of TWiV!

Links for this episode Tribunal orders release of PACE trial data (Valerie Eliot Smith) Our request for PACE trial data (virology blog) GM mosquito release on ballot (NPR) Florida Keys Mosquito Control District on TWiV #111 Cold chain and virus free plant based polio vaccine (Plant Biotechnol J) Disappointing flu vaccine effectiveness (CBC) ACIP votes down use of LAIV (CDC) LAIV as effective as inactivated flu vaccine (Ann Int Med) Flumist does work (NPR) Declining effectiveness of zoster vaccine (J Inf Dis) Efficacy of adjuvanted subunit zoster vaccine (NEJM) Risk of zoster from vaccine (J Inf Dis) Image credit: ViralZone Letters read on TWiV 403

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Weekly Science Picks

Alan - To Scale: The Solar System
Rich -  Route 66 Goes Solar
Vincent - Race for a Zika Vaccine by Siddhartha Mukherjee

Listener Picks

Bohdan - Penn and Teller on Vaccinations
Bill - Connections, Episode 1

Send your virology questions and comments to twiv@microbe.tv



73. TWiV 402: The plight of the bumblebee
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 81.40Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Rich Condit

Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV.

 

Become a patron of TWiV!

Links for this episode Marian Horzinek, 80 (ProMedMail) Polio in Nigeria (AtlanticStatProMedMail) Zika virus spreads in Miami (NYTimes) More Zika virus vaccines (Science) Back to work on Zika, Congress ! (Asbury Park Press) Lack of funding will stymie Zika vaccines (Wash Examiner) FDA OK on genetically modified mosquitoes (FDA) CMV attracts aphid vectors (TWiV #70) CMV attracts pollinating bumblebees (PLoS Path) Earth dwarfed by solar flare (jpg) Letters read on TWiV 402

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Weekly Science Picks

Alan - Solar storm that launched US space weather science
Rich -  Data storage on DNA
Dickson - Perseid meteor show live
Vincent - In the Company of Microbes by Elio Schaechter

Listener Picks

Neva - I Contain Multitudes by Ed Yong
Amanda - American Gut

Send your virology questions and comments to twiv@microbe.tv



74. TWiV 401: Vector victorious
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 82.09Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy.

 

Become a patron of TWiV!

Links for this episode Beverly Griffin, 86 (1  2  3) Zika virus in the US (CDC) Zika virus spreading in Miami (CDC) Zika virus in Florida (NY Times) NIH begins phase I trial of Zika virus DNA vaccine (NIAID) Mosquito salive enhances West Nile replication in mice (J Virol) Mosquito bites enhance virus infection (Immunity) Photo of A. aegyptii and mouse ears from Marieke Pingen Letters read on TWiV 401

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Weekly Science Picks

Alan - The Doubleclicks
Kathy - WHO ZIKV app and ZIKV Giant Microbe
Dickson - Photographer Rosamond Purcell
Vincent - Spillover: Zika, Ebola, and Beyond

Listener Picks

Ricardo - Portugal Four Days on Renewable Energy
Fatma - DeNovo: Predicting virus-host protein interactions
Stephen - How mosquitoes use six needles to suck your blood

Send your virology questions and comments to twiv@microbe.tv



75. TWiV 400: Harold '400' Varmus, a scientist for all seasons
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 95.98Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

Guest: Harold Varmus

The TWiV team is together in New York City for a conversation with Nobel Laureate Harold Varmus about his remarkable career in science.

 

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Links for this episode Varmus Laboratory Varmus and Kandel on Charlie Rose (transcript) Rescuing biomedical research Letters read on TWiV 400 Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode was made possible by PLoS Pathogens - the leading Open Access journal to publish breakthroughs in understanding pathogens and their interactions with host organisms and each other. PLOS Pathogens fosters the open exchange of ideas across fields, publishing original research on viruses, bacteria, fungi, parasites, and prions. For more information, check out www.plospathogens.org

Weekly Science Picks

Alan - A year on Earth
Rich - TWiV #1: West Nile Virus
Dickson - Chasing storms, chasing beauty
Kathy - Bioartography and FASEB image and video competition
Vincent - The Art and Politics of Science by Harold Varmus (free download)

Listener Picks

Trudy - Scientific Studies on Last Week Tonight with John Oliver

Send your virology questions and comments to twiv@microbe.tv



76. TWiV 399: Zika la femme
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 71.22Mb)

Description:

Hosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Rich Condit

The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta.

Links for this episode Zika virus disease in the US (CDC) Female to male Zika virus transmission (CDC) Zika virus in female genital tract (Lancet) Zika virus transmission in Utah (CDC and NYTimes) Olympic Zika virus risk (CDC) 15 companies on Zika virus vaccines (WSJ) Zika virus DNA vaccine in mice (Nature) Zika virus disease in Colombia (NEJM) Dengue virus antibody dependent enhancement of Zika virus (PNAS) Zika virus antibodies enhance dengue virus disease (Science) Zika virus in human placenta and developing brain (bioRxiv) Zika virus targets different human placenta cells (Cell Host Microbe) Letters read on TWiV 399

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Become a patron of TWiV.

Weekly Science Picks

Alan - CDC postmortem on Ebolavirus outbreak
Rich - Refutations to anti-vaccine memes (Twitter, Facebook)
Dickson - History of urbanization
Vincent - How to cut subject from background in Photoshop

Listener Picks

Marion - Skeptics Guide to the Universe podcast
Jennie - Leatherback turtles in Costa Rica

Send your virology questions and comments to twiv@microbe.tv



77. TWiV 398: Permission to be intuitive
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 34.37Mb)

Description:

Host: Vincent Racaniello

Guest: Sandy Weller

Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation and cleavage and packaging of viral DNA genomes.

 

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Links for this episode Cell killing by avian leukosis virus (Sandy's first paper, J Virol) ND10 protein and herpes simplex virus replication (J Virol) Recombination promoted by DNA viruses (Ann Rev Micro) HSV-1 and DNA damage response (Fut Virol) Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to twiv@microbe.tv



78. TWiV 397: Trial by Error
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 64.26Mb)

Description:

Host: Vincent Racaniello

Guest: David Tuller

Vincent speaks with David Tuller about flaws in the U.K's $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released.

 

Become a patron of TWiV!

Links for this episode Science and journalism (TWiV 111) Chronic fatigue syndrome and the CDC (virology blog) PACE trial (Lancet) Trial by error part one, two, three (virology blog) PACE economics analysis (PLoS One) All articles by David Tuller at virology blog Valerie Eliot Smith's blog Karina Hansen, prisioner of Denmark

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to twiv@microbe.tv



79. TWiV 396: Influenza viruses with Peter Palese
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 51.10Mb)

Description:

Host: Vincent Racaniello

Guest: Peter Palese

Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines.

 

Become a patron of TWiV!

Links for this episode Palese Laboratory Pig kidney neuraminidase (Hoppe Seylers Z Physiol Chem) DNAse in cytoplasmic DNA virus (Virology) Inhibitor of influenza virus neuraminidase (Virology) Influenza neuraminidase defective mutants (Virology) Swine influenza virus of 1976 RNA pattern (Nature) 1977 influenza H1N1 similar to 1950s strains (Nature) H5N1 influenza: Facts, not fear (PNAS) Influenza HA stalk immunity in ferrets (J Virol)

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to twiv@microbe.tv



80. TWiV 395: The cancer thief
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 42.13Mb)

Description:

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Stephen J. Russell

From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers.

 

Become a patron of TWiV!

Links for this episode Hokies go viral (TWiV 285) MV NIS de Myelo (TWiV 298) Remission of disseminated myeloma after MV treatment (Mayo Clin Proc) miRNA detargeting (J Virol) Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Kathy - Can you explain your science in 30 seconds? and How Far Can We Go?
Rich - Small asteroid Earth's companion
Vincent - The Gene by Siddhartha Mukherjee

Listener Picks

Dylan - Microsculpture by Levon Biss (website)

Send your virology questions and comments to twiv@microbe.tv



81. TWiV 394: Cards in a hand
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 61.63Mb)

Description:

Hosts: Vincent Racaniello and Alan Dove

Guest: Erica Ollmann Saphire

Vincent and Alan speak with Erica about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA.

 

Become a patron of TWiV!

Links for this episode Structure of antibodies bound to Ebola virus glycoprotein (PNAS) Structure of cross-reactive filovirus antibody (Cell) Multiple functions of Ebola virus VP40 protein (Cell) View video of this episode on YouTube Letters read on TWiV 394

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan - Slime Lapse
Vincent - Virus Watch

Listener Picks

Patricia - NECSSPeople Behind the ScienceThe Life Scientific
Peter - Iron Lung on eBay

Send your virology questions and comments to twiv@microbe.tv



82. TWiV 393: Lovers and livers
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 64.99Mb)

Description:

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation.

 

Become a patron of TWiV!

Links for this episode Late sexual transmission of Zika virus (Lancet) Zika virus disease in US (CDC) Zika virus lab accident (ABC News) Mosquito eradication (virology blog) Florida mosquito control (TWiV 111) How tequila mosquito (TWiV 178) SEC14L2 allows HCV replication in cell culture (Nature) Lipid peroxidation (Wikipedia) HCV replicase regulated by lipid peroxidation (Nat Med) Letters read on TWiV 393

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Also brought to you by ASV 2016

Weekly Science Picks

Alan - All About That Space
Rich - The Expanse by James S.A. Corey (SyFy)
Kathy - Five Pivotal Paragraphs in a Paper
Vincent - Agar Art Contest Winners

Listener Picks

Ted - Marshall Niremberg charts

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83. TWiV 392: Zika virus!
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Host: Vincent Racaniello

Guests: Michael Diamond, Michaela Gack, Laura Kramer, and Charles Rice

Four virologists discuss our current understanding of Zika virus biology, pathogenesis, transmission, and prevention, in this special live episode recorded at the American Society for Microbiology in Washington, DC.

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This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

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84. TWiV 391: Whiter reefs, fresh breath
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 45.17Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Rich Condit

Guests: David Pride and Forest Rohwer

If you have always wanted to know what coral reefs and the human oral cavity have in common, listen as guests David Pride and Forest Rohwer talk about their work on the microbiomes and viromes of these two environments, and you'll also understand why mucus is cool.

 

Links for this episode Lytic to temperate switching of viral communities (Nature) Viromes in ancestral holobiont Hydra (PLoS One) Phage in human oral cavity (J Oral Micro) Human oral viruses are personal, consistent, gender specific (ISME) Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Weekly Science Picks

Alan - Vax Pack Hero
Rich - Helicopter autorotation
Vincent - Live in Our Phage World by Forest Rohwer, Merry Youle, Heather Maughan, Nao Hisakawa

Listener Picks

Matt - Experiment.com

Send your virology questions and comments to twiv@microbe.tv



85. TWiV 390: Building a better mosquito trap
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 92.62Mb)

Description:

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guests: Ethan Jackson and Jonathan Carlson

Project Premonition, a Microsoft Research project that uses drones to capture mosquitoes and analyze them for pathogens, preprint servers, and three mouse models for Zika virus induced birth defects are the topics of this episode hosted by the TWiumvirate and theirs guests Ethan and Jonathan.

 

Links for this episode Project Premonition Premonition feasibility study in Grenada Zika virus causes microcephaly in mice (Cell Stem Cell) Brazilian Zika virus causes defects in experimental models (Nature) Zika virus causes placental damage and fetal demise in mice (Cell) Letters read on TWiV 390

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Also brought to you by ASV 2016

Weekly Science Picks

Dickson - Germany nearly reached 100% renewable power
Alan - Vertical City documentary and Lumino City game
Rich - Errol Morris: ‘Demon in the Freezer’
Kathy - Entropic Time YouTube by A Capella Science (watch “the making of”)
Vincent - Agar Art contest finalists

Listener Picks

Jennie - SciFi reading (scroll down)

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86. TWiV 389: Alphabet hepatitis with Stan Lemon
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 50.85Mb)

Description:

Host: Vincent Racaniello

Guest: Stan Lemon

Vincent speaks with Stan Lemon about his career in virology, from early work on Epstein Barr virus, through making essential discoveries about hepatitis A virus, hepatitis C virus, and rhinoviruses.

Links for this episode Live in Edmonton, Eh? (TWiV 235) Replication of EBV in epithelial cells (Nature) Returning to Carolina after 14 years Evolutionary origins of hepatitis A virus (TWiV 265) cre in rhinovirus genome (RNA) Naked viruses that aren't always naked (Ann Rev Virol) miR-122 and hepatitis C virus RNA (Cell Host Micr)

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to twiv@microbe.tv



87. TWiV 388: What could possibly go wrong?
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 69.73Mb)

Description:

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Preprint servers, the structure of an antibody bound to Zika virus, blocking Zika virus replication in mosquitoes with Wolbachia, and killing carp in Australia with a herpesvirus are topics of this episode hosted by Vincent, Dickson, Alan, and Kathy.

Links for this episode

biorXiv preprint server Please review Vaccines and Your Child Structure of antibody bound to Zika virus E protein (Cell Host Microbe) Wolbachia blocks Zika virus in mosquitoes (Cell Host Microbe) Zimmer on Wolbachia and Zika virus (NY Times) Fauci on Zika virus vaccine (Science) Carpageddon (The Conversation) Letters read on TWiV 388

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Also brought to you by ASV 2016

Weekly Science Picks

Dickson - EarthEnv
Alan - Research funding by lottery
Kathy - Eugenia Cheng Math and Baking
Vincent - Zika Diaries

Listener Picks

Stephen - Virus trading cards
William - Virus trading cards
Norma+Maurice - Virus trading cards
Tom - Virus trading cards

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88. TWiV 387: Quaxxed
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 66.02Mb)

Description:

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Guest: Nina Martin

Nina Martin joins the TWiV team to talk about the movie Vaxxed, her bout with dengue fever, and the latest research on Zika virus.

 

Links for this episode Public Health United Fifty Shades of Science (TEDx) Parents convicted in death of toddler (Science Based Medicine) CDC: Zika virus causes microcephaly (NEJM) Dengue virus antibodies enhance Zika virus infection (biorXiv) Zika virus in Brazilian nonhuman primates (biorXiv) Zika virus IgM in CSF of microcephalic babies (Lancet) Brain organoids for modeling Zika virus infection (Cell) Letters read on TWiV 387

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Also brought to you by ASV 2016

Weekly Science Picks

Nina - Vaccines and Your Child by Paul Offit and Charlotte Moser
Dickson - The animals of Chernobyl
Alan - Five rules of lab safety
Kathy - 20 best science images of the year?
Vincent - Massive undersea crab swarm

Listener Picks

JP - Global map of wind
Todd - Doc Martin

Send your virology questions and comments to twiv@microbe.tv



89. TWiV 386: The dolphins did it
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 82.27Mb)

Description:

Hosts: Vincent RacanielloRich Condit, and Kathy Spindler

Guests: Ted Diehl and Welkin Johnson

Ted and Welkin inform the TWiV team how the evolution of ancient retroviruses can be inferred by studying their sequences in the genomes of modern mammals, and join in a discussion of virus dispersal during different methods for drying hands.

 

Links for this episode More fun than a monkey full of viruses (TWiV 122) Tracking ancient retrovirus evolution in mammals (eLife) Virus dispersal during hand drying (J Appl Micro) More than you wanted to know about hand drying (onetwothreefourfivesix)

This episode is sponsored by ASM Agar Art ContestASM Grant Writing Course, and ASV 2016

Weekly Science Picks 1:30:20

Welkin - Lab Girl by Hope Jahren (essay)
Ted - Accidental brilliance in science
Rich - Perpetual motion?
Kathy - R0 graphic and explanation
Vincent - NWS ditches all caps forecasts

Listener Picks

Basel - Gimli Glider and Mars Climate Orbiter
Ken - Vaccination comic book

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90. TWiV 385: Failure
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 79.30Mb)

Description:

Hosts: Vincent Racaniello and Dickson Despommier

Guest: Stuart Firestein

Stuart joins Vincent and Dickson to talk about his sequel to Ignorance, a book called Failure, which seeks to make science more appealing by revealing its faults.

 

Links for this episode Stuart Firestein's site Ignorance with Stuart Firestein (TWiV Special) The pursuit of ignorance (TED) Ignorance by Stuart Firestein Failure by Stuart Firestein

This episode is sponsored by ASM Agar Art Contest and ASV 2016

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91. TWiV 384: Agent 003, a view to a fish kill
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 72.57Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove and Rich Condit

Guests: Nischay Mishra and Ian Lipkin

Nischay and Ian join the TWiVions to discuss mass die-offs of tilapia by a novel orthomyxo-like virus, Ian's editorial on the movie Vaxxed, and new vaccines to prevent dengue virus infections, including a human challenge model. 

 

Links for this episode Novel orthomyxo-like virus in Tilapia die-offs (mBio) Fish flu (TWiV 41) Anti-vaccination lunacy won't stop (WSJ) Single-dose dengue vaccine effective (J Inf Dis) Dengue vaccine needs (J Inf Dis) Composition of TV003 (J Inf Dis) Dengue vaccine mutagenesis (Curr Top Micr Imm) Dengue human challenge model (Sci Transl Med) Yellow fever alarm (STAT) Experiment: Zika virus UC Berkeley Microbiology Student Symposium Image credit Letters read on TWiV 384

This episode is sponsored by ASM Agar Art Contest, ASM Grant Writing Course, and ASV 2016

Weekly Science Picks

Rich - Dune by Frank Herbert
Alan - Adult vaccination video contest
Dickson - Ski town greenhouse
Vincent - Preprint servers: Force awakens or revenge of undead?

Listener Picks

Ken - Golden Mole Awards for Accidental Brilliance (list, video)
Jim - Linear algebra course

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92. TWiV 383: A zillion Zika papers and a Brazilian
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 86.23Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove and Kathy Spindler

Guest: Esper Kallas

Esper and the Merry TWiXters analyze the latest data on Zika virus and microcephaly in Brazil, and discuss publications on a mouse model for disease, infection of a fetus, mosquito vector competence, and the cryo-EM structure of the virus particle.

 

Links for this episode Zika virus in the Americas (Science) Co-circulation of dengue, Zika, chik in Brazil (Medicine) Murine model for Zika virus infection (Am J Trop Med Hyg) Zika virus susceptibility of A. aegypti and A. albopictus (PLoS NTD) Infectious Zika virus from saliva (EuroSurveill) Zika virus spread through saliva? (Braz Oral Res) Five Zika virus reviews (one, two, three, four, five) Zika virus and microcephaly, Brazil (MMWR) Zika virus in urine (EuroSurveill) Zika virus infection of fetus (NEJM) Real-time sharing of Zika virus data (JAMA) Image credit: Richard Kuhn Letters read on TWiV 383

This episode is sponsored by ASM Agar Art Contest and ASV 2016

Weekly Science Picks

Esper - The Chaos by Gérard Nolst Trenité and HIV pathogenesis course
Alan - Science Kombat
Dickson - Four steps to wiping out a mosquito
Vincent - Public lacks information on Zika virus
Kathy - Zika virus cryo-EM structure video

Listener Picks

Justin - Culture-independent discovery of Archaeal virus
Melinda - Zika virus open research portal and Your body battles series

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93. TWiV 382: Everyone's a little bit viral
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 78.38Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove and Kathy Spindler

Guests: Nels Elde and Edward Chuong

Nels and Ed join the TWiV team to talk about their observation that regulation of the human interferon response depends on regulatory sequences that were co-opted millions of years ago from endogenous retroviruses.

 

Links for this episode Endogenous retroviruses and regulation of innate immunity (Science) Placenta is viral (Nature) An ERV that maintains pluripotency of human embryonic stem cells (TWiV 279) Letters read on TWiV 382

This episode is sponsored by ASM Agar Art Contest and ASV 2016

Weekly Science Picks

Nels - Don't Get Me Started - Matt Giorgianni
Alan - Sun's magnetic field (paper)
Dickson - Most realistic dinosaur terrifies
Vincent - Top secret!
Kathy - Zika virus risk for US 50 cities (paper)
Ed - Watching comb jellies poop

Listener Picks

Asal - Lost paper of Gregor Mendel
Dennis - PhysicsGirl
Jacob - Second (XKCD) and ACI blogger interview

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94. TWiV 381: Add viruses and Zimmer
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 82.04Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

Guest: Carl Zimmer

Carl Zimmer joins the TWiV team to talk about his career in science writing, the real meaning of copy-paste, science publishing, the value of Twitter, preprint servers, his thoughts on science outreach, and much more.

Links for this episode Carlzimmer.com All Carl's articles at NYTimes Carl at Stat The Loom Staying afloat in the rising tide of science (Cell) Parasite Rex Planet of Viruses Handful of biologists went rogue (NYTimes)

This episode is sponsored by ASV 2016 and ASM Agar Art Contest

Weekly Science Picks

Carl - Surprising benefit of viral DNA
Alan - Global ship traffic
Dickson - Music with 2000 marbles
Vincent - The whiteboard revolution
Kathy - How to interpret UK and American advisors
Rich - Carina Storrs, science writer

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95. TWiV 380: Viruses visible in le microscope photonique
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 75.77Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

The TWiVeroos deliver the weekly Zika Report, then talk about a cryoEM structure of a plant virus that reveals how the RNA genome is packaged in the capsid, and MIMIVIRE, a CRISPR-like defense system in giant eukaryotic viruses.

 

Links for this episode First worms, then viruses, now dormant cyber pathogens (Zdziarski blog) Guillain-Barré with Zika virus in urine (Eurosurveillance) Zika virus in urine, Brazil (J Clin Virol) Zika in pregnant women in Rio (NEJM) Issues with NEJM pregnant women study (Epi-Ramble) Zika virus and meningoencephalitis (NEJM) Zika virus and acute myelitis (Lancet) Person to person transmission of Zika virus (MMWR) Pyrethroids and mouse microcephaly (one, two) Zika virus illustrations (Visual Science) Cowpea mosaic virus at high resolution (Nat Comm) MIMIVIRE confers resistance to virophage (Nature) CRISPR in a phage (TWiM 56) National Academy of Sciences GoFoc meeting Image credit Letters read on TWiV 380

This episode is sponsored by ASM Agar Art Contest and Microbe Magazine Podcast

Weekly Science Picks

Alan - Progression of Evolution
Dickson - Toddler dies of meningitis
Vincent - Gardasil ideology, not science
Kathy - The Noun Project
Rich - Physics Girl

Listener Pick

Mark - MyRadar app (iOS, Android)

Send your virology questions and comments to twiv@microbe.tv



96. TWiV 379: A mouse divided
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 80.84Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

Guest: Scott Tibbetts

Scott Tibbetts joins the TWiVists to describe his work on the role of a herpesviral nocoding RNA in establishment of peripheral latency, and then we visit two last minute additions to the Zika virus literature.

Links for this episode Noncoding RNA required for establishment of latency (mSphere) 17:20 Lessons learned from in vivo studies of a viral noncoding RNA (mSphere) 1:05:05 Zika virus in pregnant women in Rio de Janeiro (NEJM) 1:06:10 Zika virus infects cortical neural progenitors (Cell Stem Cell) 1:12:00 Image credit Letters read on TWiV 379 1:15:10

This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast 4:15, 1:05:25

Weekly Science Picks 1:42:45

Alan - Okeanos Explorer
Dickson - Rome Reborn
Vincent - Twitter Missing Manual
Scott - Best Science Images of 2015
Kathy - Space Travel Posters
Rich - GoISSWatch

Listener Pick

Peter - Antibiotics and the Problem of the Broken Market

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97. TWiV 378: Herpes plays DUBstep
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 83.25Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

Guests: Greg Smith and Mark Fuccio

Greg Smith joins the TWiVirate to reveal how his lab discovered a switch that controls herpesvirus neuroinvasion, and then we visit the week's news about Zika virus.

 

Links for this episode Dynamic ubiquitination drives herpesvirus neuroinvasion (PNAS) Releasing Zika virus data in real time (Nature) Zika virus infection and stillbirths (PLoS NTD) Zika virus infection, imported, Italy (Eurosurveillance) Letters read on TWiV 378

This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast

Weekly Science Picks

Alan - Science byline counting project
Dickson - Bill Nye on climate change
Vincent - Zdziarski's blog of things (Apple's motion to vacate)
Greg - Atlas, the next generation
Kathy - Sources of Chaco wood
Mark - How Dogs Love Us by Gregory Berns

Listener Pick

Bohdan - The real reason for brains

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98. TWiV 377: Chicken with a side of Zika
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 66.65Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVniks review the past week's findings on Zika virus and microcephaly, and reveal a chicken protein that provides insight on the restriction of transmission of avian influenza viruses to humans.

 

Links for this episode Larvicide not involved in microcephaly (CBS News) Obama seeks $1.8b for Zika virus (Guardian) Zika virus in Puerto Rico (MMWR) Zika virus in semen (EID) Zika virus in Indonesia (EID) Phylogeny of Zika virus (EID) Zika virus may cause mental disease (NYTimes) Zika virus from amniotic fluid (Lancet) Host protein underlies avian influenza host restriction (Nature) Wendy Barclay on TWiV 177 Home to roost (Cell) Image credit Letters read on TWiV 377

This episode is sponsored by 32nd Clinical Virology Symposium and Microbe Magazine Podcast

Weekly Science Picks

Alan - CDC vaccine quiz
Dickson - A telescope so powerful
Vincent - Virology Lectures 2016 (virology blogiTunes U)
Rich - Ion propulsion (Wiki)
Kathy - Spurious Correlations

Listener Pick

Johnye - Magellan telescope and van Egmond photograpy at Kids Should See This

Send your virology questions and comments to twiv@microbe.tv



99. TWiV 376: The flavi of the month is Zika
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 76.16Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

Guest: Jeremy Luban

The TWiV team discusses the latest data on Zika virus, including ocular defects in infants with microcephaly, and isolation of the entire viral genome from fetal brain tissue.

 

Links for this episode Ocular findings in infants with microcephaly (JAMA and Arq Bras Oft) Evidence of Zika virus infection in brain and placenta (MMWR) Zika virus associated with microcephaly (NEJM) Hard-core sequencing (Science) Zika virus and microcephaly (virology blog) Zika virus in the Americas (NEJM) JEV and WNV transplacental infections Rubella virus facts (WHO) Share your Zika virus reagents (virology blog) No link between anencephaly and Cache Valley Virus (EID) Image credit Letters read on TWiV 376

This episode is sponsored by 32nd Clinical Virology Symposium and ASM Microbe 2016

Weekly Science Picks

Alan - PhD Comics on gravitational waves
Dickson - 25 years of Hubble
Vincent - Amazon AWS TOS and Confirming Einstein
Rich - Mosquito mass production
Kathy - TileApp
Jeremy - IL17A and autism and The Perfect Theory by Pedro Ferreira

Send your virology questions and comments to twiv@microbe.tv



100. TWiV 375: Zika and you will find
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 87.57Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Guests: Carolyn CoyneHelen Lazear, and Jeremy Luban

The TWiVziks present everything you want to know about Zika virus, including association of infection with microcephaly and Guillain-Barré syndrome, transmission, epidemiology, and much more.

 

Links for this episode Zika outbreak in Brazil (EID) 13:40 Zika summary (ProMedMail) 19:30 Zika and microcephaly (MMWR) 27:30 Facts about microcephaly (CDC) Brazil Ministry of Health microcephaly numbers Zika spread in Americas (MMWR) Deu Zica 42:30 Microcephaly in Brazil (Lancet) 46:10 GM mosquitoes did not start Zika outbreak (Discover) 1:31:30 Debunking myths around Zika (Mad Virologist) Sexual transmission vs sexually transmissible (virology blog) 1:22:10 CDC Zika travel guidance 1:15:45 CDC on Zika and sex 1:17:10 Image credit: Esper Kallas, University of Sao Paulo Letters read on TWiV 375

This episode is sponsored by 32nd Clinical Virology Symposium and ASM Grant Writing Webinar

Weekly Science Picks 1:50:45

Alan - Jetstream Online School for Weather
Vincent - New virus watercolors from Michele Banks (onetwo)
Rich - The Mad Virologist (Facebookblog)
Kathy - Orcas in Antarctica
Jeremy - Pardis Sabeti on TED
Helen - Science Valentines
Carolyn - Three letter word missing from Zika warnings

Send your virology questions and comments to twiv@microbe.tv



101. TWiV 374: Discordance in B
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 79.79Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVniks consider the role of a cell enzyme that removes a protein linked to the 5'-end of the picornavirus genome, and the connection between malaria, Epstein-Barr virus, and endemic Burkitt's lymphoma.

 

Links for this episode Divergent requirements for removing VPg (mBio) Bond, covalent bond (TWiV 210) Link between malaria and endemic Burkitt's lymphoma (PLoS Path) Multifactorial role of malaria in Burkitt's lymphoma (PLoS Path) Plasmodium infection promotes AID-dependent B cell lymphoma (Cell) Children's cancer dependent on climatic factors (Nature) Denis Burkitt (Wikipedia) Request for PACE trial data (virology blog) Letters read on TWiV 374

This episode is sponsored by 32nd Clinical Virology Symposium and ASM Grant Writing Webinar

Weekly Science Picks

Alan - Indoor skydiving
Vincent - Cancer Virus by Crawford, Johannessen, and Rickinson
Rich - Wit
Kathy - The Only Woman in the Room by Eileen Pollack
D
ickson - Show everyone your clinical data

Send your virology questions and comments to twiv@microbe.tv



102. TWiV 373: The distinguished virology career of Julius S. Youngner
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 56.19Mb)

Description:

Host: Vincent Racaniello

Guest: Julius S. Youngner

Vincent speaks with Julius about his long career in virology, including his crucial work as part of the team at the University of Pittsburgh that developed the Salk inactivated poliovirus vaccine.

 

Links for this episode Trypsin for cell cultures (Proc Soc Exp Biol Med) Interferon induction by nonviral stimuli (J Gen Physiol) Interferons of different molecular weight (Proc Soc Exp Biol Med) Poliovirus thermal mutants (J Bacteriol) Combination of different cells in culture (Science) Equine influenza vaccine (Eq Vet J) Younger role in Salk vaccine (interview, amednews) Cutter Incident (JRSM) Video of this episode - coming as soon as I can get home!

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103. TWiV 372: Latent viral tendencies
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 87.07Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

The TWiV-osphere introduces influenza D virus, virus-like particles encoded in the wasp genome which protect its eggs from caterpillar immunity, and a cytomegalovirus protein counters a host restriction protein that prevents establishment of latency.

 

Links for this episode Ebolavirus update (ProMedMail) Influenza D virus (mBio) Vincent's influenza C virus paper (J Virol) Virus-like particles protect wasp eggs (Sci Adv) CMV protein foils cell defense against latency (Sci Adv) Image credit: Mark Letters read on TWiV 372

This episode is sponsored by ASM Grant Writing Webinar and ASM Biodefense

Weekly Science Picks

Alan - Go viral
Vincent - 3D virus popsicles (3ders, dangerous popsicles)
Rich - Galileo thermometer
Kathy - Thing Explainer by Randall Munroe

Listener Picks

Christiane - Using PowerPoint to shine

Send your virology questions and comments to twiv@microbe.tv



104. TWiV 371: Sympathy for the devil
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 91.05Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVologists discuss the finding of a second transmissible cancer in Tasmanian devils, and development of new poliovirus strains for the production of inactivated vaccine in the post-eradication era.

Links for this episode Second transmissible cancer in Tasmanian Devils (PNAS) New strains for production of IPV (PLoS Path) Synchronized switch to bivalent OPV (polioeradication.org) Virologists, start your poliovirus destruction (virology blog) Image is a painting by George Kush Letters read on TWiV 371

This episode is sponsored by ASM Grant Writing Webinar and ASM Biodefense

Weekly Science Picks

Alan - Skyfaring by Mark Vanhoenacker
Vincent - Your Cells. Their Research. Your permission?
Rich - NASA UV photos of the sun
Kathy - Aurora bike lights
Dickson - Unfilled vials

Listener Picks

Kevin - John Oliver on nutritional supplements
Jim - Tour of Australian synchrotron

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105. TWiV 370: Ten out of 15
http://www.twiv.tv/2016/01/03/... download (audio/mpeg, 75.59Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

The TWiVomics review ten captivating virology stories from 2015.

Ten virology stories from 2015 Recoding to make vaccines and study viral functions: TWiV 351: The dengue codeTWiV 362: Gotta catch ’em all and new paper Defining the virome: TWiV 365: Blood, feuds, and a foodborne disease, TWiV 362: Gotta catch ’em all, TWiV 356: Got viruses?, TWiV 355: Baby’s first virome, TWiV 342: Public epitope #1, TWiV 323: A skid loader full of viromes
Ebola outbreak wanes, vaccines tested, persistence noted: TWiV 361: Zombie viruses on the loose, TWiV 349: One ring to vaccinate them all, TWiV 341: Ebolavirus experiences, TWiV 336: Brought to you by the letters H, N, P, and Eye, TWiV 335: Ebola lite Spillovers and scares: TWiV 347: Rose rosette and squirrel roulette, TWiV 351: The dengue code, TWiV 364: It’s not SARS 2.0, TWiV 365: Blood, feuds, and a foodborne disease The “Gain of Function” debate continues: TWiV 321: aTrip and a pause, TWiV 351: The dengue code, TWiV 354: The cat in the HAART, TWiV 363: Eat flu and dyad, and the NSABB’s new draft report Detailed mechanisms of pathogenesis: TWiV 336: Brought to you by the letters H, N, P, and eye, and TWiV 345: How a vaccine got the nod - plus numerous episodes (324, 328, 329, 330, 339, 343, 349, 353, 369) where we talked about basic research that undergirds these clinically important discoveries. Dengue vaccines:  Trial TWiV 319: Breaking breakbone. Dengvaxia was licensed in December in Mexico, Philippines, and Brazil (12/28); paper we didn’t have time to cover about broadly neutralizing Abs from viremic patients and another paper from same group with X-ray crystal structure of Ab + gpE. Why do some RNA viruses undergo antigenic variation and others do not? TWiV 340: No shift, measles TWiV 346: A double helical career TWiV 345: How a vaccine got the nod Letters read on TWiV 370

This episode is sponsored by ASM Microbe and ASM Biodefense

Weekly Science Picks

Alan - Scientifics online
Vincent - Giant squid in Tokyo Harbor
Kathy - A Year of Sky

Listener Picks

Daniel - Paper Life
Stephen - How to deal with science denialists
Venkat - Kabisa

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106. TWiV 369: Camel runny noses and other JNK
http://www.twiv.tv/2015/12/27/... download (audio/mpeg, 81.91Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

A swarm of virologists discusses testing of a MERS coronavirus vaccine for camels, and how a neuronal stress pathway reactivates herpes simplex virus.

Links for this episode MERS coronavirus vaccine for camels (Science) WHO MERS summary Neuronal stress pathway and herpes simplex virus reactivation (Cell Host Micr) Stress flips a chromatin switch (Cell Host Micr) How herpes simplex virus reactivates (UNC press release) Histone antibodies database New antibody portal (UNC press release) Image credit Letters read on TWiV 369

This episode is sponsored by Clinical Virology Symposium

Weekly Science Picks

Alan - SpaceX Falcon 9 landing
Vincent - Scientists: Engage the public! and Lego contest winners
Kathy - Google Ngram viewer

Listener Picks

Dennis - Americapox: The missing plague
Mark - WeatherSpark and Quasispecies theory

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107. TWiV 368: Infected, you will be
http://www.microbe.tv/twiv/twi... download (audio/mpeg, 82.05Mb)

Description:

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

A plaque of virologists explores the biology of Zika virus and recent outbreaks, and the contribution of a filamentous bacteriophage to the development of biofilms.

Links for this episode

More cowbell (Wikipedia) Microcephaly in Brazil (Outbreak News) Non-vector borne Zika transmission (EID) Zika virus outside Africa (EID) Zika virus possible sexual transmission (EID) Zika virus in saliva (J Clin Virol) Dengue's cousin Zika (Micr Inf) Filamentous phage promote biofilm assembly (Cell Host Micr) Biofilm history (MSU) Pseudomonas phage Pf1 Image credit Letters read on TWiV 368

This episode is sponsored by Clinical Virology Symposium and ASM Microbe

Weekly Science Picks

Alan - Twelve days of norovirus
Vincent - This Week in Evolution
Rich - In the Kingdom of Ice by Hampton Sides
Kathy - Kajanjian lecture on Frederick Novy and Milestones ceremony at UM

Listener Picks

Peter - What if anti-vax, anti-science movement won?
Stephen - Scandalous origin of vaccines
Pritesh - Absurd way of doing business

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108. TWiV 367: Two sides to a Coyne
http://www.twiv.tv/2015/12/13/... download (audio/mpeg, 75.05Mb)

Description:

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guests: Carolyn Coyne and Coyne Drummond

Two Coynes join the TWiV overlords to explain their three-dimensional culture model of polarized intestinal cells for studying enterovirus infection.

 

Links for this episode Carolyn and placentas on TWiV 193 Three-dimensional cell culture model (mSphere) Bioreactor video (JoVE) Neurovirologist Richard T. Johnson, 84 (Hopkins and virology blog) Tardigrade HGT disputed (BioRxiv) Exaptation of archaeal virus capsid protein from Cas4 (Biol Dir) Image credit Letters read on TWiV 367

This episode is sponsored by ASM Microbe

Weekly Science Picks

Kathy - Tardigrade genome sequence (video)
Alan - Antibiotic action nonprofit group
Vincent - Ex Machina and genome editing moratorium
Rich - Launch photography by Ben Cooper
Kathy - HIV life cycle in video (paper)
Dickson - 2015 Nobel Lectures Physiology or Medicine
Carolyn - Metapneumovirus entry

Listener Picks

Tom - Global host-pathogen database
Trudy - Madame Curie by Eve Curie

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109. TWiV 366: Doctorates down under
http://www.twiv.tv/2015/12/06/... download (audio/mpeg, 42.14Mb)

Description:

Host: Vincent Racaniello

Guests: Carla Giles, Zoe Dyson, Brianna McLean, and Caitlin O'Brien

In Melbourne, Australia, Vincent speaks with four PhD students about their research projects and what it's like to get a doctorate down under.

Video of this episode: view at YouTube

 

This episode is sponsored by ASM Microbe and ASM Biodefense.

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TWiV is a MicrobeTV Production



110. TWiV 365: Blood, feuds, and a foodborne disease
http://www.twiv.tv/2015/11/29/... download (audio/mpeg, 75.51Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus.

Links for this episode Battle over genome editing (Wired) 10:05 First description of CRISPR in E. coli (J Bacteriol) 14:00 Cas genes identified (Mol Micro) 14:20 CRISPR-Cas provides immunity to bacterial viruses (Science) 15:35 Cas9-crRNA complex mediates DNA cleavage (PNAS) 16:55 Dual RNA-guided DNA endonuclease in bacterial immunity (Science) 17:50 Genome engineering using CRISPR/Cas (Science) 18:50 Cpf1 endonuclease (Cell) 23:10 Classification of CRISPR/Cas systems (Nat Rev Micro) 23:50 Summit on gene editing 21:25 Novel human virus in transfusion recipients (mBio) 27:00 Origins of hepatitis A virus in small mammals (PNAS) 55:05 Image credit Letters read on TWiV 365 7:00, 1:20:35

This episode is sponsored by ASM MicrobeASM Biodefense, and the 32nd Clinical Virology Symposium. (1:10, 1:18:30)

Weekly Science Picks 1:36:30

Kathy - Tardigrade genome sequence (video)
Alan - XKCD on Gates polio eradication site
Vincent - Lifting the Impenetrable Veil by Charles Calisher

Listener Picks

Judi - Jennifer Doudna's Ted Talk
Ramon - Map of the Sky

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111. TWiV 364: It's not SARS 2.0
http://www.twiv.tv/2015/11/22/... download (audio/mpeg, 90.21Mb)

Description:

Hosts: Vincent RacanielloRich Condit, and Kathy Spindler

Guests: Ralph Baric and Vineet Menachery

Vincent, Rich, and Kathy speak with Ralph and Vineet about their research on the potential of SARS-like bat coronaviruses  to infect human cells and cause disease in mice.

 

Links for this episode Zoonotic potential of SARS-like bat viruses (Nature) SARS-CoV susceptibility loci via collaborative cross (PLoS Genetics) 47:00, 57:25 Ebright and Wain-Hobson quotes (Nature) 1:17:20 Misleading press release (UNC) 1:24:45 Super powerful SARS 2.0 (not!) (Motherboard) SARS-like bat virus can jump without mutating (not!) (Daily Mail) 1:26:30 Photo credit Letters read on TWiV 364 1:47:40

This episode is sponsored by Mt. Sinai Department of Microbiology (2:10)ASM Education (33:25), and the 32nd Clinical Virology Symposium (1:51:30)

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:53:00

Kathy - California Dept of Public Health
Rich - Leafy greens on space station
Vincent - Mechanical keyboards and TWiV on Perfect your podcast

Listener Picks

Jesse - Networking for Nerds by Alaina G. Levine
Russell - Worldmapper

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112. TWiV 363: Eat flu and dyad
http://www.twiv.tv/2015/11/15/... download (audio/mpeg, 73.04Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

The TWiVers reveal influenza virus replication in the ferret mammary gland and spread to a nursing infant, and selection of transmissible influenza viruses in the soft palate.

 

Links for this episode Photos of my visit to OHSU (Facebook) 6:30 Folta departs (Facebook) 9:25 T-VEC approved for melanoma (FDA) 14:45 Talimogene laherparepvec (Wikipedia) 15:10 T-VEC phase III trial (J Clin Oncol) 17:35 How drugs are named (PopSci) 16:35 Influenza transmission in mother-child dyad (PLoS Path) 23:10 Soft palate and influenza transmission (Nature) 41:00 Image credit Letters read on TWiV 363 1:09:30

This episode is sponsored by Mt. Sinai Department of MicrobiologyASM Education, and ASM Biodefense and Emerging Diseases Conference

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:29:00

Kathy - Insect gears
Alan - Bye, Bye, Ebola
Rich - Hedy Lamarr
Vincent - Should we resurrect extinct species?

Listener Picks

Jennie - Bye, Bye, Ebola
Peter - Epidemics on edX

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113. TWiV 362: Gotta catch 'em all
http://www.twiv.tv/2015/11/08/... download (audio/mpeg, 77.80Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, Rich Condit, and Kathy Spindler

With their usual verve, the virus virtuosos illuminate a new method to identify all the viral nucleic acids in a sample, and regulation of viral gene expression by codon usage. 

Links for this episode Virome capture sequencing (mBio) 15:40 Codon usage regulates viral gene expression (PNAS) 40:00 Harold S. Ginsberg (Wikipedia) 7:15 Letters read on TWiV 362 6:50, 1:03:20

This episode is sponsored by ASM Education: ASM MOOC 5:45

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:39:20

Kathy - Adam Savage, Andy Weir and Chris Hadfield talk about The Martian
Alan - Project Apollo photo archive - and video
Rich - Watch A Bowling Ball And Feather Falling In A Vacuum
Dickson - California drought
Vincent - Does AAAS care about Ebola anymore?

Listener Picks

Anonymous - Lives saved by vaccination
Paul - Science articles: A guide
Judi - How a virus invades your body

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114. TWiV 361: Zombie viruses on the loose
http://www.twiv.tv/2015/11/01/... download (audio/mpeg, 70.60Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Rich Condit

The TWiVsters discuss Frederick Novy's return from retirement to recover a lost rat virus, and evidence for persistence of Ebolavirus in semen.

 

Links for this episode Frederick Novy and the rat virus (Ann Int Med) 18:20 The rat virus (J Inf Dis) 22:55 Recovery of the rat virus (J Inf Dis) 35:20 Ebola sitrep 42:25 Meningitis in Glaswegian Ebolavirus nurse (ProMedMail, Medscape) 45:50 Sexual transmission of Ebolavirus (NEJM) 50:25 Ebolavirus RNA persistence in semen (NEJM) 1:04:25 Airplane banner falls into Hudson River (jpg) Image credit Letters read on TWiV 361 7:25, 1:13:25

This episode is sponsored by ASM Education: ASM MOOC 3:50

Weekly Science Picks 1:27:05

Alan - Sticky
Rich - Arthur C. Clarke predicts the Internet (so did Vannevar Bush)
Dickson - Nikon Small World Photomicrography winners
Vincent - Pat Schloss on microbiome initiative

Listener Picks

Awkward Skeptic - 16 year old wins Google prize for detecting Ebolavirus

Timestamps by Jennifer. Thanks!

Send your virology questions and comments to twiv@twiv.tv



115. TWiV 360: From Southeastern Michigan
http://www.twiv.tv/2015/10/25/... download (audio/mpeg, 65.97Mb)

Description:

Hosts: Vincent Racaniello and Kathy Spindler

Guests: Michael ImperialeAdam Lauring, and Akira Ohno

Vincent visits the University of Michigan where he and Kathy speak with Michael, Adam, and Akira about polyomaviruses, virus evolution, and virus assembly, on the occasion of naming the department of Microbiology & Immunology a Milestones in Microbiology site.

Links for this episode

World Polio Day 3:20 Mole Day 5:25 The rat virus (J Inf Dis) 20:00 Polyomavirus miRNAs (Curr Op Virol) 39:30 Costs of GOF pause (mBio) 45:00 Lethal mutagenesis of influenza virus (J Virol) 1:03:35 Mutational robustness in RNA virus evolution (Nat Rev Micro) 52:00 Membrane binding of gag (mBio) 1:12:55 Cell proteins in retrovirus particles (J Virol) 1:23:15 Michael's twitter Adam's twitter Video of this episode - view below or at YouTube Weekly Science Picks 1:27:30

Kathy - Ada Lovelace and Charles Babbage Lego #1 and #2 and Ada Lovelace Day
Vincent - MiSciWriters

Listener Picks

Junio - XKCD marks the spot
Kari - Spoonflower

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116. TWiV 359: A Blossom by any other name
http://www.twiv.tv/2015/10/18/... download (audio/mpeg, 62.65Mb)

Description:

Host: Vincent Racaniello

Guest: Blossom Damania

Vincent speaks with Blossom about her laboratory's research on Kaposi's sarcoma-associated herpesvirus, including how it transforms cells, the switch between lytic and latent replication, and its interaction with the innate immune system of the host.

 

Links for this episode Damania Laboratory Modulation of cGAS-STING by KSHV (PNAS) KSHV vIRF1 interacts with ISG15 pathway member (J Virol) KSHV NLR homolog inhibits inflammasome (Science) KSHV inhibition of PI3K and mTOR (Blood) KSHV confers survival advantage to endothelial cells (Cancer Res) UNC Global Oncology Program Blossom on Twitter Video of this episode - view at YouTube

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117. TWiV 358: Virology and proteomics with Ileana Cristea
http://www.twiv.tv/2015/10/11/... download (audio/mpeg, 57.91Mb)

Description:

Host: Vincent Racaniello

Guest: Ileana Cristea

Vincent meets up with Ileana at Princeton University to talk about how her laboratory integrates molecular virology, mass spectrometry-based proteomics, and bioinformatics to unravel the interplay between virus and host.

 

Links for this episode Cristea Laboratory Ileana's work previously on TWiV 269 Blowing off steam (Cell Host Micr) Nuclear viral DNA sensors (J Biol Chem) mSystems Video of this episode - view at YouTube (coming soon!)

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118. TWiV 357: Mistletoe on the Tree of Life
http://www.twiv.tv/2015/10/04/... download (audio/mpeg, 94.58Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

Guest: Jens Kuhn

Jens joins the TWiVomics to discuss the strengths and weaknesses of viral taxonomy, including its history and evolution, how viruses are ordered, and why T. rex was classified without having a living isolate.

 

Links for this episode Jens' previous TWiV (283) 5:15 International Committee on the Taxonomy of Viruses (ICTV) 27:50 ICTV 9th Report 32:55 Classifying viruses by capsid architecture (Curr Opin Virol) 1:43:00 Image credit Letters read on TWiV 357 10:55, 1:55:40

Timestamps by Jennifer. Thanks!

Weekly Science Picks 56:30, 2:07:15

Alan - The Jefferson Grid
Rich - Summer of Science
Kathy - Bill Nye dances The Click
Dickson - The Martian
Jens - How I Killed Pluto, Life in Our Phage World, Why the Seahorse Tail is Square
Vincent - Does the public trust science? (videos, summaries)

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119. TWiV 356: Got viruses?
http://www.twiv.tv/2015/09/27/... download (audio/mpeg, 80.23Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

Guest: Stephanie Neal

Stephanie joins the super professors to discuss the gut virome of children with serious malnutrition, caterpillar genes acquired from parasitic wasps, and the effect of adding chemokines to a simian immunodeficiency virus DNA vaccine.

 

Links for this episode Invitrogen Science Hero Awards 15:05 Gut DNA viromes of twins with severe malnutrition (PNAS) 34:30 Random forests 48:00 Wasps engineer caterpillars (PLoS Genetics) 50:20 Chemokine-adjuvanted SIV DNA vaccine (Mucos Immunol) 1:02:20 Guide to chemokines (pdf) Role for CCR10 in IgA secreting cell accumulation (J Immunol) CCL28 controls IgA plasma cell accumulation (J Exp Med) In vivo electroporation 1:07:25, 1:09:50 Kathy's groan (jpg) Image credit Letters read on TWiV 356 14:55 Weekly Science Picks 1:18:35, 1:45:30

Alan - Plates from Hooke's Micrographia
Rich - The Wright Brothers by David McCullough
Kathy - Spore evaporation-driven engines (video and article)
Dickson - Color variations of Pluto and Lunar total eclipse
Stephanie - The science of moldy cheese by Carl Zimmer
Vincent - But Why?

Listener Pick of the Week

Reed - The Bench Warmers Podcast

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120. TWiV 355: Baby's first virome
http://www.twiv.tv/2015/09/20/... download (audio/mpeg, 80.89Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiV team considers the effect of a Leishmaniavirus on the efficacy of drug treatment, and the human fecal virome and microbiome in twins during early infancy.

Links for this episode Announcing mSphere 5:50 Leishmania virus influences drug outcome (paper 1paper 2) 25:15 Human gut virome and microbiome in infants (Nat Med) 46:00 Multiple displacement amplification (Wiki) 46:00 Virome of adult twins (Nature) 49:15 Illumination by Kevin Folta 1:31:00 Folta story at RetractionWatch 1:41:40 Image credit Letters read on TWiV 355 9:40, 1:20:30

This episode is sponsored by ASMGAP 5:00

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:42:20

Alan - Vexed Muddler store
Rich - Ivanpah Solar Power Facility
Kathy - The real Kermit
Dickson - Animal Portraits
Vincent - Adventures of the Regatjes, Vaccines by Susan Nasif

Listener Pick of the Week

Jacob - Great Wall of China keeps rabbits out

Send your virology questions and comments to twiv@twiv.tv



121. TWiV 354: The cat in the HAART
http://www.twiv.tv/2015/09/13/... download (audio/mpeg, 82.61Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The esteemed doctors of TWiV review a new giant virus recovered from the Siberian permafrost, why influenza virus gain of function experiments are valuable, and feline immunodeficiency virus. 

Links for this episode Non-viral proteins in vaccinia virus particles (Arch Virol) 8:15 Thing a week (Jonathan Coulton, downloads) 23:20 Immortal Life pornographic? Not! (HuffPost) 25:25 Mollivirus sibericum (PNAS) 27:00 Don't worry about Frankenvirus (WashPost) 27:10 We need flu GOF research (articleWisc State JScience) 40:35 Isolation of FIV (Science) 50:20 FIV at Cornell Vet 1:06:25 FIV latency (Retrovirol) 1:08:00 FIV-receptor interactions (Curr Op Virol) 1:08:45 Clin aspects FIV infection (Viruses) FIV antivirals (Viruses) 1:10:05 How to treat FIV 1:10:45 Bud's FIV therapy 1;10;50 FIV vectors (CSH Prot) 1:13:50 Lion FIV (Proc Biol Sci) FIV in cat species (J Virol) 1;01;45 ACIP HVP vaccine recommendations (MMWR) 1:28:45 HPV and cancer (CDC) 1:33:45 Cervical cancer screening (pdf, CDC) Letters read on TWiV 354 7:45, 1:17:10

This episode is sponsored by ASMGAP

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:40:40

Alan - Experience Curiosity
Rich - Primrose School
Kathy - Egg drop solutions
Dickson - Dragonflies by Pieter van Dokkum
Vincent - NASA guide to air-filtering houseplants

Listener Pick of the Week

Amir - Publons (Nature article)

Send your virology questions and comments to twiv@twiv.tv



122. TWiV 353: STING and the antiviral police
http://www.twiv.tv/2015/09/06/... download (audio/mpeg, 69.72Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

The TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles.

Links for this episode 28 years of poliovirus shedding (PLoS Path) 36:50 NOT a rare poliovirus (Wash Post) 44:35 Ukraine polio outbreak (ProMedMail) 41:00 Virus particle transfer of cGAMP (Science onetwo) 47:50 cGAS on TWiV 222 47:05 Image credit Letters read on TWiV 353 6:30, 1:10:25

This episode is sponsored by ASMGAP 3:10

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:27:50

Alan - Miniature calendar
Kathy - Dr. Brainlove (prologuev. 2.0,  IndieGoGo)
Dickson - The Ph.D. Movie
Vincent - Ghostery

Listener Pick of the Week

Ramon - Children die
Chris - ASMLive at ICAAC/ICC

Send your virology questions and comments to twiv@twiv.tv



123. TWiV 352: Science art with Michele Banks
http://www.twiv.tv/2015/08/30/... download (audio/mpeg, 29.00Mb)

Description:

Host: Vincent Racaniello

Guest: Michele Banks

Vincent meets up with Michele Banks in Washington, DC to discuss her career as a creator of science-themed art.

 

Links for this episode Michele Banks on Twitter Artologica Michele's blog The Finch and the Pea Joseph Cornell Not Exactly Rocket Science (Ed Yong) Tree of Life (Jonathan Eisen) Home Microbiome Study Kitten Microbiome Project Science Online The Vexed Muddler Luke Jerram A Daily Dish (Klari Reis) Neuroscience art (Greg Dunn) Ai Weiwei Video of this episode - coming soon Video of Michele working in her studio - view at YouTube

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124. TWiV 351: The dengue code
http://www.twiv.tv/2015/08/23/... download (audio/mpeg, 73.25Mb)

Description:

Hosts: Vincent Racaniello, Dickson DespommierAlan DoveRich Condit, and Kathy Spindler

The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation of dengue virus by recoding the genome.

Links for this episode Paula Pitha-Rowe (Balt Sun) Novel poxvirus (CID) H1N1 and gain-of-function debate (mBio) Recoding dengue virus genome (PNAS) Attenuation by dinucleotide frequency change (PNAS) Codon pair and dinucleotide bias not distinguished (PNAS) Codon pair deoptimization artefact of CG/UA change (eLife) Can engineering subdue viral vaccine reversion? (Virus Evol) Attenuation by a thousand cuts (NEJM) Image credit Letters read on TWiV 351 Weekly Science Picks

Alan - Genetic roulette
Rich - The Huntington
Kathy - Simulated vomiting machine (video)
Dickson - Last Cassini Saturn flyby
Vincent - Decaying Still Life (YouTube)

Listener Pick of the Week

Ken - Cave meterology (Times, Nature)

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125. TWiV 350: Viral gene therapy with Katherine High
http://www.twiv.tv/2015/08/16/... download (audio/mpeg, 26.60Mb)

Description:

Host: Vincent Racaniello

Guest: Katherine A. High

Vincent speaks with Katherine High about her career and her work on using viral gene therapy to treat inherited disorders.

This episode is drawn from one of twenty-six video interviews with leading scientists who have made significant contributions to the field of virology, part of the new edition of the textbook Principles of Virology.

 

Links for this episode Katherine A. High, MD AAV gene therapy for congenital blindness (Sci Trans Med) Gene therapy for hemophilia (Hematol) AAV capsid decoys (Sci Trans Med) Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



126. TWiV 349: One ring to vaccinate them all
http://www.twiv.tv/2015/08/09/... download (audio/mpeg, 76.11Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Rich Condit

Vincent, Alan and Rich explain how to make a functional ribosome with tethered subunits, and review the results of a phase III VSV-vectored Ebolavirus vaccine trial in Guinea.

 

Links for this episode Social media specialist position at ASM WHO dismisses Catholic church on vaccine safety U of T Dean resigns over anti-vaccine course (Tor Star) Vaccine Adverse Event Reporting System (VAERS) Countering anti-vaccination attitudes (PNAS) Designer ribosome (Nature) rVSV-EBOV preliminary report (NEJM) rVSV-EBOV phase III interim report (pdf, Lancet) World on verge of Ebolavirus vaccine (WHO) Ebolavirus vaccine in Africa (virology blog) Letters read on TWiV 349 11:55

This episode is sponsored by ASM GAP

Weekly Science Picks

Alan - Above and Beyond
Rich - DSCOVR (Dark moon side crossing Earth)
Vincent - Stuxnet virus (WiredYouTube)

Listener Pick of the Week

Konrad - Stated Clearly

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



127. TWiV 348: Chicken shift
http://www.twiv.tv/2015/08/02/... download (audio/mpeg, 72.92Mb)

Description:

Hosts: Vincent Racaniello and Rich Condit

Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Marek's disease viral vaccine that allows transmission of virulent viruses.

 

Links for this episode Virology tenure-track position at NCI (pdf) ASM Agar Art Contest Nigeria on brink of polio eradication (Nature) Dengue in Africa (Tyler Sharp) Permissive vaccines and virulence (PLoS Biol) Marek's disease vaccines and virulence (Ed Yong) Image credit Letters read on TWiV 348

This episode is sponsored by ASM GAP

Weekly Science Picks

Rich - Swan-Ganz catheter (Wikivideo)
Vincent - Mobile DNA III

Listener Pick of the Week

Kevin - Synthetic prions

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128. TWiV 347: Rose rosette and squirrel roulette
http://www.twiv.tv/2015/07/26/... download (audio/mpeg, 100.28Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Rich Condit

Vincent, Alan, and Rich discuss the virus behind rose rosette disease, and fatal human encephalitis caused by a variegated squirrel bornavirus.

Links for this episode Virology tenure-track position at NIH (pdf) 7:00 Voinnet investigation is a Swiss Federal secret (twitter) 12:25 Rose rosette disease in Ft. Worth (Star Telegram) 29:35 Rose rosette virus discovered (J Gen Virol) 34:25 Emeravirus (ViralZone) 33:55 Eriophyid mites (MI Botanical Garden) 32:40 Mite vector of rose rosette disease (U Florida) 34:55 Image credit Squirrel bornavirus associated with human encephalitis (NEJM) 38:40 Poll: How do you consume podcasts? 1:21:40 Letters read on TWiV 347 8:10, 59:40

This episode is sponsored by ASM GAP and ICAAC/ICC

Time stamps by Jennifer. Thanks!

Weekly Science Picks 1:17:05

Alan - National Immunization Awareness Month (Twitter campaign)
Rich - Rosie Revere, Engineer by Andrea Beaty
Vincent - iPhone owns podcasts (9to5Mac)

Listener Pick of the Week

Sandra - World Zoonoses Day graphic
Peter - Mammal-carnivorous plant mutualism (bat and shrew)

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129. TWiV 346: A double helical career
http://www.twiv.tv/2015/07/17/... download (audio/mpeg, 70.04Mb)

Description:

Hosts: Vincent RacanielloRich Condit, and Kathy Spindler

Guest: Joan Steitz

This episode was recorded at the 34th Annual Meeting of the American Society for Virology, where Vincent, Rich, and Kathy spoke with Joan Steitz, a tireless promoter of women in science and one of the greatest scientists of our generation.

Links for this episode ASV annual meeting, Western University Steitz Laboratory at Yale University Steitz Laboratory on Twitter Panoramic photo of ASV TWiV by Matt Evans Photos of ASV2015 (Facebook) Video of this episode - view at YouTube Weekly Science Picks

Kathy - Charity Hall
Rich - Ribosome binding sites of phage R17 mRNA
Vincent - Pluto flyby

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130. TWiV 345: How a vaccine got the nod
http://www.twiv.tv/2015/07/11/... download (audio/mpeg, 71.39Mb)

Description:


Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

The TWiVonauts review how the weather affects West Nile virus disease in the US, benefit of B cell depletion for ME/CFS patients, and an autoimmune reaction induced by influenza virus vaccine that leads to narcolepsy.

Links for this episode Virology faculty position, University of Toledo Weather and West Nile virus disease (AJTMH) B cell depletion benefits ME/CFS patients (PLoS One) Antibodies to influenza nucleoprotein cause narcolepsy (Science Transl Med) Letters read on TWiV 345

This episode is sponsored by ASM GAP - turn your science into a company

Weekly Science Picks

Dickson - Algal DMS releasing enzyme
Alan - Science of beer aging
Kathy - The Art of Science winners
Vincent - The future of Lego plastics

Listener Pick of the Week

Eric - Economics in One Lesson by Henry Hazzilit
Stephen - The Martian by Andy Weir (audiobook)

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131. TWiV 344: Glasgwegians go viral
http://www.twiv.tv/2015/07/04/... download (audio/mpeg, 40.99Mb)

Description:

Host: Vincent Racaniello

Guests: Ruth JarrettGlen Nemerow, and Esther Schnettler

At the Glasgow Science Festival microTALKS, Vincent speaks with Ruth, Glen, and Esther about their research on viruses and Hodgkin lymphoma, adenovirus structure and entry into cells, and interactions between arthropod borne viruses and their hosts.

Links for this episode Glasgow Science Festival microTALKS Hodgkin lymphoma (Histopath) HHV-6 and Hodgkin lymphoma (PLoS One) Adenovirus entry (PLoS Path) Adenovirus membrane penetration (Virology) Mosquito pathways that limit CHIK replication (PLoS Negl Trop Dis) Tick antiviral RNAi (Nucl Acids Res) Video of this episode - view at YouTube

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132. TWiV 343: The silence of the turnips
http://www.twiv.tv/2015/06/28/... download (audio/mpeg, 81.24Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVerinoes discuss the potential for prion spread by plants, global circulation patterns of influenza virus, and the roles of Argonautes and a viral protein in RNA silencing in plants.

Links for this episode Prions in plants (Cell Rep) 11:35 Global influenza virus circulation (Nature) 20:40 Rough patch for plant RNA silencing (Lab Times) 29:50 Role of Argonaute proteins in plant viral defense (PLoS Path) 32:15 Rub-inoculation (YouTube) 42:45 Image credit Letters read on TWiV 343 4:00, 1:11:45

Timestamps by Jennifer. Thank you!

Weekly Science Picks 1:41:45

Dickson - Global rainfall and snowfall map and A Week in the Life of Rain
Alan - Automated patch clamp
Kathy - More Women in Science mini Legos
Rich - The Martian trailer
Vincent - It's a bug's life

Listener Pick of the Week

May - p53 by Sue Armstrong

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133. TWiV 342: Public epitope #1
http://www.twiv.tv/2015/06/21/... download (audio/mpeg, 70.41Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVniks discuss the structure of a virus that reproduces in an extreme environment, long-term consequences of Ebolavirus infection, and VirScan, a method to identify the different virus infections you have had in your lifetime.

Links for this episode Virus with A-form DNA (Science) Viruses in the extreme (virology blog) Sequelae of Ebolavirus infection (Lancet Inf Dis) Long term Ebolavirus effects (virology blog) Take the chili ME challenge Serological profiling of human viral infections (Science) Your viral past (virology blog) Letters read on TWiV 342

Timestamps by Jennifer. Thank you!

Weekly Science Picks

Dickson - Incredible photos
Alan - Alone in a room full of science writers
Kathy - Calico cats and Siamese cats
Rich - Missing link in evolution
Vincent - Podcasts saving NPR and Podcasting blossoms

Listener Pick of the Week

Jenny - What Bill Gates is afraid of
Neva - The Kardashian Index

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134. TWiV 341: Ebolavirus experiences
http://www.twiv.tv/2015/06/14/... download (audio/mpeg, 61.51Mb)

Description:

Host: Vincent Racaniello

Guests: Adam KucharskiGillian Slack, and Emma Thomson

Vincent returns to the University of Glasgow MRC-Center for Virus Research and speaks with Emma, Gillian, and Adam about their ebolavirus experiences: caring for an infected patient, working in an Ebola treatment center in Sierra Leone, and making epidemiological predictions about the outbreak in west Africa.

Links for this episode Tribute to Richard Elliott Donate to mesothelioma research for Richard Elliott CVR science blog Photos of our visit Ceilidh goes viral! Video of this episode - view below or at YouTube

Timestamps by Jennifer. Thank you!

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135. TWiV 340: No shift, measles
http://www.twiv.tv/2015/06/07/... download (audio/mpeg, 80.32Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiV teams reviews a MERS-coronavirus serosurvey and an outbreak in South Korea, and constraints on measles virus antigenic variation.

Links for this episode Richard Elliott on TWiV 177 MERS-CoV outbreak, South Korea (ProMedMail) MERS-CoV serosurvey (Lancet Inf Dis) Biolabs in your backyard (USA Today) Constraints on measles virus antigenic variation (Cell Rep) Selection bias and bombers (John D. Cook) Virology (journal) Image credit: Cameron Moll Letters read on TWiV 340 Weekly Science Picks

Dickson - Singapore Flower Dome  and Cloud Forest
Alan - Rescuing biomedical research
Kathy - The value of basic research
Rich - Virology 60th Anniversary Issue
Vincent - Careers in virology: Science writing and journalism

Listener Pick of the Week

Pritesh - How T cells kill cancer cells
Ramon - The power of herd immunity

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136. TWiV 339: Herpes and the sashimi plot
http://www.twiv.tv/2015/05/31/... download (audio/mpeg, 68.83Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

Tre TWiV amici present three snippets and a side of sashimi: how herpesvirus inhibits host cell gene expression by disrupting transcription termination.

Links for this episode Searching for Steamer in the oceans Lassa fever death in NJ (CDC and NYTimes) Transgenic mouse model for MERS-CoV (J Virol) First West Nile virus disease case in Texas Herpesvirus disrupts host transcription termination (Nat Comm) Sashimi plots Broad benefits of measles virus immunization (TWiM #104) Avian influenza outbreak (NPR) The virome in health and disease (Immunity) Image credit Letters read on TWiV 339 Weekly Science Picks

Alan - Fooling millions into thinking chocolate helps weight loss
Kathy - Approaching Pluto
Vincent - ASM Agar art contest

Listener Pick of the Week

Daniel - FB pages you need to stop sharing from (one and two)
Ken - Bird box science (canceled)

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137. TWiV 338: Coyotes have sushi
http://www.twiv.tv/2015/05/23/... download (audio/mpeg, 41.20Mb)

Description:

Hosts: Vincent Racaniello and Kathy Spindler

Guest: Laura Newcomb

Vincent and Kathy visit Laura Newcomb at California State University San Bernardino, where they talk about Laura's viral tatoos, and a protein that protects the mosquito brain from lethal flavivirus infection.

Links for this episode Neuron-specific mosquito antiviral mechanism (PLoS Path) Letters read on TWiV 338 Photos of our visit Video of this episode - view at YouTube Weekly Science Picks

Laura - NP siRNA inhibits different influenza viruses (Antiviral Res)
Kathy - Time-lapse mining
Vincent - Does the public trust science?

Listener Pick of the Week

Paul - Degree-Off XKCD
Peter - Ebola containmentHans RoslingeLife podcast,  Naked Scientists

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138. TWiV 337: Steamer
http://www.twiv.tv/2015/05/17/... download (audio/mpeg, 47.36Mb)

Description:

Host: Vincent Racaniello

Guests: Michael Metzger and Steve Goff

Vincent meets up with Michael and Steve to discuss their finding of a transmissible tumor in soft shell clams associated with a retrovirus-like element in the clam genome.

Links for this episode Hemocytic leukemia in soft shell clam (Sci Total Environ) Activation of Steamer in neoplastic hemocytes (PNAS) Transmission of clonal cancer cells in clams (Cell) Steve Goff on TWiV #76 Image credit

Timestamps by Jennifer. Thank you!

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139. TWiV 336: Brought to you by the letters H, N, P, and Eye
http://www.twiv.tv/2015/05/10/... download (audio/mpeg, 69.04Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVsters explore mutations in the interferon pathway associated with severe influenza in a child, outbreaks of avian influenza in North American poultry farms, Ebolavirus infection of the eye weeks after recovery, and Ebolavirus stability on surfaces and fluids.

This episode is sponsored by @ASM Conferences and ASM Microbe

Links for this episode Life threatening influenza and IRF7 deficiency (Science) Whole exome sequencing (Wikipedia) Herpes encephalitis in children with Trif deficiency (TWiV 175) Avian influenza in the US (USDAProMedMailCDC) Ebola eye (NEJMNYTimes) Viral persistence (Virology lectures, pdf) Uveitis (National Eye Institute) Image credit Stability of Ebolavirus on surfaces (EID) Ignorance with Stuart Firestein (TWiV Special) Letters read on TWiV

Timestamps by Jennifer. Thank you!

Weekly Science Picks

Alan - Winogradsky time-lapse
Rich - Missing link in evolution of complex cells
Kathy - Grantome
Dickson - National Geographic Landscape Photo of the Day
Vincent - PyMol and Chimera

Listener Pick of the Week

Mauricio - Vax!



140. TWiV 335: Ebola lite
http://www.twiv.tv/2015/05/02/... download (audio/mpeg, 75.77Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVumvirate discusses a whole Ebolavirus vaccine that protects primates, the finding that Ebolavirus is not undergoing rapid evolution, and a proposal to increase the pool of life science researchers by cutting money and time from grants.

This episode is sponsored by ASM Microbe and ICAAC/ICC

Links for this episode Possible sexual transmission of Ebolavirus (MMWR) Ebolavirus whole-virus vaccine protects primates (Science) Biologically contained Ebolaviruses (PNAS) Ebolavirus is evolving but not changing (Virology) Ebolavirus not undergoing rapid evolution (Science) Letters read on TWiV 335

Timestamps by Jennifer. Thank you!

Weekly Science Picks

Alan - Pinboard
Rich - Academic medicine investment in medical research
Kathy - Tissue paper stop motion animation
Dickson - Do peer review panels select best science proposals?
Vincent - MMR and autism: Still no association

Listener Pick of the Week

Ramon - Autism by MMR vaccine status
Mehul -  Ebolavirus disease course
Justin - Molecular Biology of Bacterial Viruses by Gunther S. Stent

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141. TWiV 334: In vino virus
http://www.twiv.tv/2015/04/26/... download (audio/mpeg, 66.24Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVles talk about endogenous viruses in plants, sex and Ebolavirus transmission, an outbreak of canine influenza in the US, Dr. Oz, and doubling the NIH budget.

This episode is sponsored by SciMed Solutions and ASM Education.

Links for this episode Pinot noir and viruses (Wine Spectator) 35:00 Endogenous florendoviruses (Nat Commun) 35:30 Sex and Ebolavirus transmission (WHOCDCNYTimes) 54:10 Ebolavirus waiting (NYTimes) 57:35 Canine influenza outbreak (ProMedNorthStarVets) 1:01:10 Dr. Oz under fire (NYTimes) 1:06:20 TV doctors (Brit Med J) 1:09:50 Double the NIH budget (NYTimes) 1:11:45 Image credit: Grapes and Caulimovirus Letters read on TWiV 334 6:10

Timestamps by Jennifer. Thank you!

Weekly Science Picks 1:17:05

Alan - NIH RFI: How do we fix this mess?
Rich - Editing embryos (PopSciProt Cell)
Kathy - Creative class presentations (onetwothreefour)
Dickson - The most tornadoes
Vincent - Apollo 13, 45 years later (ArsIEEEFarewell)

Listener Pick of the Week

Johnye - Rudolf and Leopold Blaschka

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142. TWiV 333: Naturally curious chimeras
http://www.twiv.tv/2015/04/18/... download (audio/mpeg, 64.64Mb)

Description:

Host: Vincent Racaniello

Guests: Ben Fensterheim, Megan Freeman, Bobak Parang, and Meredith Rogers

Vincent returns to Vanderbilt University and meets up with Ben, Megan, Bobak, and Meredith to learn about life in the Medical Scientist Training Program.

Links for this episode MTGR1 and intestinal secretory lineage allocation (Faseb J) Coronaviruses induce macropinocytosis (mBio) PD-1 and respiratory virus reinfection (J Immunol) Vanderbilt MSTP on Facebook Video of this episode: view at YouTube

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143. TWiV 332: Vanderbilt virology
http://www.twiv.tv/2015/04/12/... download (audio/mpeg, 67.07Mb)

Description:

Host: Vincent Racaniello

Guests: Seth BordensteinJames Crowe, and Mark Denison

Vincent visits Vanderbilt University and meets up with Seth, Jim, and Mark to talk about their work on a virus of Wolbachia, anti-viral antibodies, and coronaviruses.

 

Links for this episode SARS-CoV error correction (PLoS Path) 19:00 Marburg virus neutralization by a human antibody (Cell one and two) 56:35 Phage WO, Wolbachia and Drosophila (Peer J) 1:02:00 Seth's blog Symbionticism 1:31:30 Seth on Twitter Video of this episode: view at YouTube

Timestamps by Jennifer. Thank you!

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144. TWiV 331: Why is this outbreak different from all other outbreaks?
http://www.twiv.tv/2015/04/05/... download (audio/mpeg, 93.87Mb)

Description:

The TWiV team discusses the possible association of the respiratory pathogen enterovirus D68 with neurological disease.

This episode is sponsored by SciMed Solutions and ASM Education.

Links for this episode Clusters of AFP associated with enterovirus D68 (Lancet) 31:35 Novel outbreak enterovirus D68 strain (Lancet Inf Dis) 53:00 Enterovirus D68 in Norway (Euro Surveill) 1:12:00 Unknown enemy (Nature) 1:10:40 Enterovirus D68 on TWiV 302 Letters read on TWiV 331 8:00, 1:23:50

Timestamps by Jennifer. Thank you!

Weekly Science Picks 1:53:50

Alan - OU0POLIO ham radio special event station (on air reports)
Rich - Crane building itself (YouTube)
Kathy - Vaccine heroes LEGO project
Dickson - Life at the limits
Vincent - Emperor of all Maladies film and Conference gender balance

Listener Pick of the Week

Jake - Designing useful microbes

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



145. TWiV 330: A swinging gate
http://www.twiv.tv/2015/03/29/... download (audio/mpeg, 76.25Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVers explain how a protein platform assists the hepatitis C virus RNA polymerase to begin the task of making viral genomes.

Links for this episode NYAS Afterschool STEM Mentoring Program Concerns about editing the human germline (ScienceNature) Engineering the perfect baby (MIT Tech Rev) RNA recognition by HCV polymerase (Science) Kickstarting an RNA polymerase (Science) A protein platform for priming (virology blog) Apoenzyme and holoenzyme (Wikibooks) Ebolavirus will not become a respiratory pathogen (virology blog) Burkholderia pseudomallei (CDC) Letters read on TWiV 330

Timestamps by Jennifer. Thank you!

Weekly Science Picks

Alan - X-Flare 2.1 captured
Rich - Volvo ocean race drops research buoys (YouTube)
Kathy - Nature double-blind peer review
Dickson - Largest cave in the world
Vincent - New program for early-career scientists

Listener Pick of the Week

Michael - Space Engine and Kerbal Space Program
Varun CN - Incognito by David Eagleman

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146. TWiV 329: Pox in the balance
http://www.twiv.tv/2015/03/22/... download (audio/mpeg, 75.74Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiV team reviews identification of immune biomarkers in CFS/ME patients, and how a cell nuclease controls the innate immune response to vaccinia virus infection.

Links for this episode Immune signatures in ME/CFS (Science Adv) 11:15 Systemic exertion intolerance disease (Lancet) 19:50 Cell nuclease controls anti-viral responses (Cell Host Micr) 25:10 Poxvirus decapping enzymes prevent innate responses (Cell Host Micr) 1:15:40 Caps off to poxviruses (Cell Host Micr) Drummer Mohr (YouTube) 1:24:05 Bornavirus in squirrel breeders (ProMedMail) 1:28:45 Principles of Microbial Diversity 5:30 Journal of Microbiology & Biology Education 1:24:25 Cross-stitch by Anne Marie 1:34:40 Letters read on TWiV 329 1:25:00

Timestamps by Jennifer. Thank you!

Weekly Science Picks 1:35:10

Alan - NASA Solar Dynamics Observatory video
Rich - Mutagenic chain reaction (Video: Genome editing with CRISPR)
Kathy - Science Ambassadors Program
Dickson - Street Art
Vincent - End Polio Now

Listener Pick of the Week

Ross - Three PhD Comics on Nature vs Science (onetwothree)
Ricardo - Demographic Party Trick

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



147. TWiV 328: Lariat tricks in 3D
http://www.twiv.tv/2015/03/15/... download (audio/mpeg, 63.45Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVocateurs discuss how the RNA polymerase of enteroviruses binds a component of the splicing machinery and inhibits mRNA processing.

 

Links for this episode Viral polymerase binds Prp8 to inhibit mRNA splicing (PLoS Path) Prp8 protein of the spliceosome (RNA) Nuclear entry of poliovirus RdRp (Virol) RNA processing (TWiV 216) Measles in USA (CDC) Principles of Microbial Diversity Journal of Microbiology & Biology Education Letters read on TWiV 328 Weekly Science Picks

Alan - Positively Negative (PLoS One)
Rich - ISS assembly (YouTube)
Kathy - Ancient trees
Dickson - Carolyn Porco
Vincent - Tony Fauci on Ebola outbreak (YouTube)

Listener Pick of the Week

David - Shot by Shot
Judi - The Power of Herd Immunity

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148. TWiV 327: Does a gorilla shift in the woods?
http://www.twiv.tv/2015/03/08/... download (audio/mpeg, 70.78Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The eTWiVicators review evidence that the HIV-1 group O epidemic began with a single cross-species transmission of virus from western lowland gorillas.

Links for this episode Traces of ATCV-1 associated with laboratory contamination (PNAS) ATCV-1 findings not explained by contamination (PNAS) Origin of HIV-1 group O epidemic in western lowland gorillas (PNAS) INNO-LIA Principles of Microbial Diversity Image credit: John Letters read on TWiV 327 Weekly Science Picks

Alan - California bill to eliminate personal vaccine exemptions
Rich - Kepler observatory (Kepler-186f)
Kathy - USGS disease map
Dickson - Philosphy of Microbiology by Maureen O'Malley
Vincent - Nautilus

Listener Pick of the Week

Ken - Life in our phage world (onlinebook party); All about that base
Neal - Gilles van Cutsem at CROI
Ricardo - Flow hive

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149. TWiV 326: Giving HIV a flat tyr
http://www.twiv.tv/2015/03/01/... download (audio/mpeg, 64.25Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Rich Condit

The sternutating TWiVers discuss preventing infection of cells and animals by a soluble CD4-CCR5 molecule that binds to HIV-1 virus particles.

Links for this episode Dif-tor heh smusma (NY Times) Immunization preterm premature infants (Thanks, Johnye!) HIV and SHIV protection conferred by eCD4-Ig (Nature) Tyrosine sulfation (Wikipedia) GBV-C and Ebolavirus infection (J Virol) Letters read on TWiV 326 Weekly Science Picks

Alan - Toms River by Dan Fagin
Rich - Spin by Robert Charles
Vincent - FCC votes for net neutrality (ArsTechnica)

Listener Pick of the Week

Neal - Why doesn't everyone get the flu vaccine?
Fernando - Zombie Jonas Salk hunts idiots
Neva - Physicists in biology

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150. TWiV 325: Wildcats go viral
http://www.twiv.tv/2015/02/22/... download (audio/mpeg, 56.58Mb)

Description:

Host: Vincent Racaniello

Guests: Rollie Clem and Lorena Passarelli

Vincent visits the 'Little Apple' and speaks with Rollie and Lorena about their work on mosquito-born viruses and baculoviruses.

Links for this episode Apoptosis inhibition in A. aegypti (Apop) Initiator caspase in armyworm (Insect Bioc Mol Biol) Manipulating apoptosis in A. aegypti (J Virol) Viral inhibitors of apoptosis (Sem Cell Dev Biol) Baculoviruses: Sophisticated pathogens (PLoS Path) Baculovirus morphogenesis (Virol) Barriers to baculovirus success (Virol) Baculovirus endonuclease (J Virol) Baculovirus DNA damage response (J Virol) Video of this episode - view at YouTube

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151. TWiV 324: Viruses in the miR may appear more numerous
http://www.twiv.tv/2015/02/15/... download (audio/mpeg, 79.89Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

Guest: Lee Feinman

Lee joins the TWiV team to discuss the value of post-doctoral training, and how a cellular microRNA assists in the replication of hepatitis C virus.

Links for this episode Spin by Robert Charles Wilson Immunization of preterm infants (Dev Period Med) miR-122 alters HCV translation-replication balance (Cell Host Micr) Holding a miR to HCV (TWiV 180) Treating hepatitis C by blocking miR-122 (virology blog) Click chemistry (Wikipedia) Image credit Ebolavirus sitrep (WHO) Letters read on TWiV 324 Weekly Science Picks

Lee - Furthering America's Research and Upgoer five and six
Alan - Best snow shovel
Rich - Ripple tank
Kathy - Fractals
Dickson - World Press Photo Contest 2015
Vincent - What to do about antivax politicians and physicians

Listener Pick of the Week

Patricia - Future of Bioscience Graduate & Postdoc training
Paul - This is my son Griffin, and he may have measles

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



152. TWiV 323: A skid loader full of viromes
http://www.twiv.tv/2015/02/08/... download (audio/mpeg, 72.52Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

The family TWiVidae discuss changes in the human fecal virome associated with Crohn's disease and ulcerative colitis.

Links for this episode Enteric virome changes in inflammatory bowel disease (Cell) Gov. Christie stumbles on vaccination (NY Times) Anti-vax psychology (NPR) Vaccine skeptic changes her mind (NPR) Ebolavirus sitrep (WHO) Letters read on TWiV 323 Weekly Science Picks

Alan - Sitesucker
Rich - Snake picked wrong dinner
Dickson - Sapporo Snow Festival
Vincent - Mapping NYC subway DNA

Listener Pick of the Week

Gretchen - Scientific way to cut a cake
Leslie - Principles of Virology, Second Edition

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



153. TWiV 322: Postcards from the edge of the membrane
http://www.twiv.tv/2015/02/01/... download (audio/mpeg, 73.55Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

The TWiVodes answer listener email about hantaviruses, antivirals, H1N1 vaccine and narcolepsy, credibility of peer review, Bourbon virus, influenza vaccine, careers in virology, and much more.

Links for this episode Bourbon virus (NY Times) Thogotovirus (ViralZone) Drug induced apoptosis and HIV infection (PLoS One) Mumps cases and outbreaks (CDC) Opossums as pets? (doc) Cat found Letters read on TWiV 322 Weekly Science Picks

Alan - Boom by Tony Horowitz
Kathy - Octopus supermom
Dickson - Macrophotography
Vincent - Virology lectures 2015 (virology blog and YouTube)

Listener Pick of the Week

Paul - Illsville: Fight the Disease
Ramon - Vaccinate! Do it for the testicles
Sandra - Who can you trust?

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



154. TWiV 321: aTRIP and a pause
http://www.twiv.tv/2015/01/25/... download (audio/mpeg, 69.20Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

Guest: Paul Duprex

Paul joins the TWiV team to discuss the current moratorium on viral research to alter transmission, range and resistance, infectivity and immunity, and pathogenesis.

Links for this episode Wain-Hobson objects (onetwothreefour) Influenza H7N1 transmission experiments (J Virol) Epistemological perspective on aTRIP experiments (mBio) Limited scientific value and risk (mBio) Reply to limited scientific value (mBio) Risks and benefits of aTRIP experiments (mBio) Apocalypse as rhetorical device in aTRIP debate (mBio) Moratorium on aTRIP experiments Moratorium on aTRIP research (mBio) Risks of influenza virus transmission experiments (mBio) Reply to risks of influenza virus transmission experiments (mBio) Vagueness of moratorium on aTRIP experiments (mBio) Role of aTRIP experiments in vaccine recommendation (mBio) Use of aTRIP data for surveillance and preparedness (mBio) aTRIP towards lexiconic precision (mBio) October 2014 NSABB meeting on aTRIP NAS aTRIP meeting (YouTube) MERS-CoV aTRIP experiments exempted (ScienceInsider) aTRIP: time for a debate (Nat Rev Micro) Effect of aTRIP moratorium on trainee plans (mBio) Make the moratorium permanent (Sci Am) Image credirt: John Morris Letters read on TWiV 321 Weekly Science Picks

Alan - In a Sunburned Country by Bill Bryson
Paul - Saving the lives of our dogs (blog post)
Kathy - New all-female Lego set
Dickson - Female storm-chaser
Vincent - Despommier Photo Art

Listener Pick of the Week

Jacob - Exaggeration in news and press releases (BMJ)
Peter - Quartet game (photos: onetwothreefourfive)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



155. TWiV 320: Retroviruses and cranberries
http://www.twiv.tv/2015/01/18/... download (audio/mpeg, 76.96Mb)

Description:

Host: Vincent Racaniello

Guest: John Coffin

Vincent speaks with John Coffin about his career studying retroviruses, including working with Howard Temin, endogenous retroviruses, XMRV, chronic fatigue syndrome and prostate cancer, HIV/AIDS, and his interest in growing cranberries.

Links for this episode John Coffin (Wikipedia) Specific HIV integration sites (Science) Novel retrovirus in modern birds (J Virol) Recombinant origin of XMRV (Science) Cranberry harvest (jpg)

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156. TWiV 319: Breaking breakbone
http://www.twiv.tv/2015/01/11/... download (audio/mpeg, 70.20Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America.

 

Links for this episode Efficacy of dengue vaccine (NEJM) Preventing dengue (NEJM) Dengue viruses (Scitable) Intention to treat (Wikipedia) Image credit: Jean-Yves Sgro Letters read on TWiV 319 Weekly Science Picks

Alan - The Toaster Project by Thomas Thwaites
Rich - SpaceX reusable rocket (SpaceX)
Kathy - Antarctica: A Year on Ice
Dickson - NHL Mumps outbreak and Hubble Andromeda image
Vincent - We the Microbiologist

Listener Pick of the Week

Neva - Mosquito earrings
Basel - Flu vaccine selection meeting

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



157. TWiV 318: Last year in virology
http://www.twiv.tv/2015/01/04/... download (audio/mpeg, 82.79Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

The TWiV gang reviews ten fascinating, compelling, and riveting virology stories from 2014.

 

Ten virology stories of 2014 Ebola virus outbreak (TWiV 314309308307306305304303302298297283) Directional uncoating of rhinovirus RNA (TWiV 267) Pandemic pathogen controversy (TWiV 287) Viral evolution (TWiV 275) Borna virus inhibition by endogenous DNA (TWiV 303) MERS-CoV in dromedary camels (TWiV special, TWiV 287) Oncolytic measles virus (TWiV 298) Amazing norovirus findings (TWiV 312 and 313) Toxin delivery to aphids (TWiV 272) The Salk Legacy (TWiV 281) Links for this episode Bat-filled tree (Science) Possible Ebola virus lab exposure (CIDRAP) Mishandling of Ebola virus sample (NY Times) Where could Ebola virus strike next? (NPR) New Legos of female scientists Photo and cookie by Kathy Spindler Letters read on TWiV 318 Weekly Science Picks

Alan - Mystery photos from CERN
Rich - Adam E. Cohen: Bringing bioelectricity to light
Kathy - Wired's top microbe stories of 2014
Dickson - Mouse joke
Vincent - The Science of Epidemics (Time Inc Special)

Listener Pick of the Week

Neva - Sir Bacteriophage
Sagi - An unboring polio documentary

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



158. TWiV 317: Brazil goes viral
http://www.twiv.tv/2014/12/28/... download (audio/mpeg, 58.21Mb)

Description:

Host: Vincent Racaniello

Guests: Eurico Arruda, Gustavo Acrani, Cintia Bittar, Tatiana Domitrovic, and Suellen Galvino-Costa

On his second trip to Brazil, Vincent joins Eurico to speak with three young virologists, Gustavo, Cintia, Tatiana, and Suellen, about their work and their prospects for careers in science.

Video of this episode: view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



159. TWiV 316: The enemy of my enemy is not my friend
http://www.twiv.tv/2014/12/21/... download (audio/mpeg, 62.81Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Vincent, Alan, Rich and Kathy discuss how interleukin 10 modulation of Th17 helper cells contribute to alphavirus pathogenesis.

Links for this episode

IL10 modulation of Th17 cells during alphavirus pathogenesis (PNAS) Th17 cells involved in influenza mediated gut injury (J Exp Med) Helper T cells 2014-15 flu season (CDC) Key facts about flu & flu vaccine (CDC) Does the flu vaccine work? (Turbid plaque) Effectiveness of flu vaccine (virology blog) Image credit Letters read on TWiV 316 Weekly Science Picks

Alan - It came from the pond
Rich - Wanderers
Kathy - The Sense of Style by Steven Pinker
Vincent - Life in Our Phage World

Listener Pick of the Week

Fernando - Reality based?

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



160. TWiV 315: Must be something in the water
http://www.twiv.tv/2014/12/14/... download (audio/mpeg, 59.95Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Vincent, Alan, Rich and Kathy association of a virus with sea star melting disease, and the finding of a phycodnavirus in the oropharynx of humans with altered cognitive functions.

Links for this episode National Influenza Immunization Week (CDC) Densovirus associated with sea star wasting disease (PNAS) A virus that melts sea stars (virology blog) Chlorovirus in human oropharynx (PNAS) Algal virus in humans (virology blog) Image credit Letters read on TWiV 315 Weekly Science Picks

Alan - ReelLife Science 2014 Winners
Rich - The Martian by Andy Weir
Kathy - Dance Your Ph.D. Winner
Vincent - Time Person of the Year 2014 - The Ebola Fighters

Listener Pick of the Week

Ricardo - MiniPCR
Eli - Let's outsmart Ebola together AND The Ebola virus explained

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



161. TWiV 314: Einstein goes viral
http://www.twiv.tv/2014/12/07/... download (audio/mpeg, 59.79Mb)

Description:

Host: Vincent Racaniello

Guests: Kartik ChandranGanjam Kalpana, and Margaret Kielian

Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells.

Links for this episode Antibodies that protect against Sudan virus (ACS Chem Biol) Ebola virus entry requires NPC1 (EMBO J) A toggle switch for virus entry (Nat Comm) Imaging alphavirus exit (J Virol) Defects in HIV-1 unable to interact with INI1 (Retrovirol) Cell cycle arrest by INI1 (Mol Cell Biol) Video of this episode - view at YouTube

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162. TWiV 313: With viruses like these, who needs enemas?
http://www.twiv.tv/2014/11/30/... download (audio/mpeg, 67.59Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Rich Condit

Vincent, Alan, and Rich discuss how norovirus, an enteric virus, can replace the functions of the gut microbiome.

Links for this episode Ebola virus update (WHO) Norovirus can replace functions of gut microbiome (Nature) Post-vaccinal distemper encephalitis (N Z Vet J) Novel sea otter poxvirus (J Wildl Dis) Poliovirus escapes antibodies (virology blog) CDC whistleblower saga (Sci Based Med) Snopes on CDC whistleblower Image credit Letters read on TWiV 313 Video of this episode - view at YouTube Weekly Science Picks

Alan - Retrocomputing
Rich - Where is Rosetta?
Vincent - Antares rocket explosion

Listener Pick of the Week

Simon - Relatively Prime
Mark - Giant Microbes

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



163. TWiV 312: She sells B cells
http://www.twiv.tv/2014/11/23/... download (audio/mpeg, 64.25Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria.

This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.

Links for this episode Ebola virus appropriations (White House) ASM Ebola FAQ Quarantine due to Ebola virus in semen (NPR) Enteric bacteria promote norovirus infection of B cells (Science) Norovirus emerges (Zimmer) Stephanie Karst on TWiV 134 Image credit Letters read on TWiV 312 Weekly Science Picks

Alan - How Ebola airlifts work
Kathy - Fred Murphy's Foundations of Virology
Rich - Pendulum wave
Dickson - Young Dipterists
Vincent - Microbes After Hours: Ebola and TWiV iPhone 6 case

Listener Pick of the Week

Alane - Health Map
Todd - Formaldehyde in vaccines

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



164. TWiV 311: Bulldogs go viral
http://www.twiv.tv/2014/11/16/... download (audio/mpeg, 52.12Mb)

Description:

Host: Vincent Racaniello

Guests: Zhen Fu and Biao He

Vincent visits the University of Georgia where he speaks with Zhen Fu and Biao He about their work on rabies virus and paramyxoviruses.

Links for this episode

Blood-brain permeability and rabies survival (Antiviral Res) Rabies induces blood-brain permeability (J Virol) Virus neutralizing antibodies in CNS of non-lethal rabies (PLoS Neg Trop Dis) RSV vaccine based on PIV5 (Vaccine) New mumps vaccine (J Virol) PIV5-based influenza virus vaccine (J Virol) Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv 



165. TWiV 310: From bacteriophage to retroviruses with Ann Skalka
http://www.twiv.tv/2014/11/09/... download (audio/mpeg, 40.79Mb)

Description:

Hosts: Vincent Racaniello and Glenn Rall

Guest: Ann Skalka

Vincent and Glenn meet up with Ann and talk about her long and productive career in virology, from biochemistry to bacteriophage lambda to retroviruses.

 

Links for this episode Skalka laboratory Asilomar Conference on recombinant DNA Unexpected inheritance (PLoS Path) Viral sequences in vertebrate genomes (J Virol) Assembly of integrase multimers (J Biol Chem) Cell cycle and retrovirus integration (J Cell Bioch) Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



166. TWiV 309: Ebola email
http://www.twiv.tv/2014/11/02/... download (audio/mpeg, 81.60Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVocytes answer questions about Ebola virus, including mode of transmission, quarantine, incubation period, immunity, and much more.

This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.

Links for this episode Guidelines for monitoring potentially infected persons (CDC) ASTMH meeting rejects attendees from Ebola countries (ScienceInsider) Defense Threat Reduction Agency call for Ebola virus proposals NSF calls for Ebola virus proposals Review of Ebola virus human-human transmission (CDC) How Firestone controlled Ebola virus (MMWR) Could Reston virus be a vaccine for Ebola virus? (virology blog) Letters read on TWiV 309 Weekly Science Picks

Alan - CDC Influenza activity weekly maps
Kathy - Going Deep with David Rees
Rich - Virology Special Issue: Giant Viruses
Dickson - Nikon Small World Winners
Vincent - TWiM #90 and Republicans are not scientists

Listener Pick of the Week

Paul - Tricks and Tools of Great Scientists
Yegor - Hardcore History
Amanda - Vaccine ingredientsAnti-vaxers damageMinds of anti-vaxers

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



167. TWiV 308: The Running Mad Professor
http://www.twiv.tv/2014/10/26/... download (audio/mpeg, 57.52Mb)

Description:

Host: Vincent Racaniello

Guest: Tom Solomon

Tom talks with Vincent about viral central nervous system infections of global importance, Ebola virus, and running the fastest marathon dressed as a doctor.

 

Links for this episode World's biggest brain Tom's YouTube channel Sex, drugs, and emerging viruses (TedX) The Running Mad Professor Image credit: ClickLiverpool Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



168. TWiV 307: Ebola aetiology
http://www.twiv.tv/2014/10/19/... download (audio/mpeg, 67.05Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

Guest: Tara C. Smith

Tara Smith joins the TWiEBOVsters to discuss the Ebola virus outbreak in west Africa, spread of the disease to and within the US, transmission of the virus, and much more.

 

This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.

Links for this episode Science communications fellow at ASM Nation turns to science (New Yorker) CDC employees in West Africa (CDC) UN botched Ebola response (AP) Ebola czar (CNN) Ebola vaccine and budget cuts (HuffPo) Collins' ridiculous meme (NOT junk) How to quarantine against Ebola (Mukherjee) Ebola fear in Heartland (Tara Smith) Massive mutations in Ebola virus (PunditFact) Ebola airport screening (CDC) What is contact tracing? (video) (CDC) Inside MSF Ebola unit (YouTube) Ebola tech bulletin (DuPont) HAI controversies Letters read on TWiV 307 Weekly Science Picks

Alan - Fall foliage map
Kathy - Interviews with Peter Piot (onetwo) and autobiography
Vincent - The Ebola connection

Listener Pick of the Week

Brooke - N.B. Designs on Etsy
Victor - SMBC

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



169. TWiV 306: This Week in Ebolavirus
http://www.twiv.tv/2014/10/12/... download (audio/mpeg, 74.05Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

The Grand Masters of the TWiV discuss Ebola virus transmission, air travel from West Africa, Ebola virus infectivity on surfaces, the Dallas Ebola virus patient, and Ebola virus in dogs.

This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.

Links for this episode Science communications fellow at ASM CDC Ebola virus fact sheet (pdf) CDC Ebola virus infographic (pdf) No Reston virus replication in arthropods (Am J Trop Med Hyg) Inoculation of plants and animals with Ebola virus (Emerg Inf Dis) Arthropod studies during Ebola virus outbreak (J Inf Dis) Medbox: Ebola toolbox Facts about bushmeat and Ebola (pdf, CDC) Should US ban incoming flights from West Africa? Survey: should flights from Ebola countries be banned? (NBC News) Ebolavirus content at virology blog and TWiV Volunteer to help with the Ebola virus crisis Ebola and Anthropology webinar Asymptomatic Ebola virus infection (Lancet) Persistence of Ebola virus during 1995 outbreak (J Inf Dis) Assessment of Ebola virus transmission risk (J Inf Dis) Ebola virus transmission risk factors (Emerg Inf Dis) UV inactivation of Ebola virus (J Virol) Ebola virus persistence in darkness (Arch Virol) UV sensitivity of Ebola virus (Arch Virol) Treatment of Ebola virus infection with brincidofovir (virology blog) Ebola virus in domestic animals (Dev Biol) Ebola virus in dogs (Emerg Inf Dis) Ebola screening at US airports (CDC) Letters read on TWiV 306 Weekly Science Picks

Alan - The Sixth Extinction by Elizabeth Kolbert
Kathy - Seeing the Invisible
Vincent - 2014 Scientific American Science in Action Award winner

Listener Pick of the Week

Mauricio - Investigating a mystery disease
Heather - Diversity Journal Club
Johnye - Flu Attack!

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



170. TWiV 305: Rhymes with shinola
http://www.twiv.tv/2014/10/04/... download (audio/mpeg, 63.70Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States.

This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.

Links for this episode Science communications fellow at ASM Can we get AIDS from mosquito bites? (J La State Med Soc) Why mosquitoes cannot transmit AIDS Isolation of Bundibugyo ebolavirus in Uganda (PLoS Path) Ebola virus disease outbreak, Nigeria (MMWR) Nigeria contains Ebola virus outbreak (NY Times) First Ebola virus case in US (NY Times) Ebola virus disease: USA ex Liberia (ProMedMail) First imported Ebola virus case in US (CDC) Assessing risk of spread of Ebola virus (PLoS Currents) How contagious is Ebola virus? (NPR) Estimating reproductive index of Ebola virus (PLoS Currents) Polio-like illness, EV-D68 suspected (ProMedMail) Polio-like illness, North America (ProMedMail) Four deaths associated with EV-D68 (NY Times) Image credit: Pigott et al eLife Letters read on TWiV 305 Video of this episode - view at YouTube Weekly Science Picks

Alan - Under the knife, episode 1
Kathy - UCSC Ebola genome portal
Vincent - Annual Review of Virology, volume 1

Listener Pick of the Week

Alan - H5N1
Peter - Vomiting Larry
Dara - I just can't wait for my vaccine!

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



171. TWiV 304: Given X, solve for EBOV
http://www.twiv.tv/2014/09/28/... download (audio/mpeg, 67.41Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

Guest: Jeff Shaman

The TWiV team consults an epidemiologist to forecast the future scope of the Ebola virus epidemic in West Africa. 

This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.

Links for this episode Science communications fellow at ASM Estimating future cases in Ebola virus epidemic (MMWR) Columbia prediction of Ebola outbreak The Ebola emergency (NEJM) Q&As on Ebola virus transmission (CDC) Ebola virus transmission to monkeys (Lancet) Aerosol infection of monkeys with Ebola virus (Int J Exp Path) Ebola virus replication in pigs (J Inf Dis) Pathology of aerosol Ebola virus infection in rhesus macaques (Vet Path) Murine model of Ebolavirus infection (Viruses) Ebola virus transmission from pigs to non-human primates (Sci Rep) Transmission risks in BSL4 laboratory (Sci Rep) Why Ebola virus is unlikely to go airborne (Vox) Letters read on TWiV 304 Weekly Science Picks

Alan - Fabre's Book of Insects
Kathy - Origami microscope for 50 cents
Dickson - Landsat 8
Vincent - Some advice from Jeff Bezos

Listener Pick of the Week

Justin - Brazil releases 'good' mosquitoes to fight dengue fever

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



172. TWiV 303: Borna this way
http://www.twiv.tv/2014/09/21/... download (audio/mpeg, 64.18Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

The TWiV team discusses transmission of Ebola virus, and inhibition of Borna disease virus replication by viral DNA in the ground squirrel genome.

This episode of TWiV is brought to you by the Department of Microbiology at Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. The Department is presently looking to recruit any prospective graduate students to apply to our program by the December 1st deadline. Interested postdocs are also encouraged to contact faculty of interest. For more information about the Department, please visit www.mssm.edu/MIC.

Links for this episode 2014 Ebola virus outbreak at Healthmap Ebola virus transmission from bodily fluids and fomites (JID) Value of gain of function experiments (mBio) Rich Condit in the Washington Post on Ebola virus NPR on Ebola virus transmission What we are not afraid to say about Ebola virus (virology blog) Inhibition of Borna disease virus by an endogenous element (PNAS) Bornavirus at ViralZone Photo: Thirteen-lined ground squirrel (image credit) Letters read on TWiV 303 Weekly Science Picks

Alan - Photogrammar
Kathy - Refrigerate your tomatoes?
Dickson - Robot swarm
Vincent - The Beginner's guide to winning the Nobel Prize by Peter Doherty

Listener Pick of the Week

Dee - Publish scientific research faster on TWiST
Basel - Lego microscope (vote for it)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



173. TWiV 302: The sky is falling
http://www.twiv.tv/2014/09/14/... download (audio/mpeg, 77.89Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVers discuss the growing Ebola virus outbreak in West Africa, and an epidemic of respiratory disease in the US caused by enterovirus D68.

Links for this episode Cancer patient saved by measles virus Ebola virus genome sequences (Science) Robert Garry on Ebola outbreak Aerosol transmission WHO Ebola outbreak summary CDC Ebola outbreak page Ebola outbreak epi curve CED Ebola outbreak info graphic Ebola response roadmap (CDC) Ebola outbreak discussion at ICAAC Human trial of Ebola virus vaccine (CNN) Chimpanzee adenovirus vectored Ebola virus vaccine (Nat Med) How US  Ebola patients were cured (Sci Amer) Ebola outbreak could affect 20,000 (NY Times) Ebola infection control resources NLM free access to Ebola papers Science Ebola papers open access Gates donates money for Ebola outbreak (Wash Post) Smuggled bushmeat? (Newsweek) What we are not afraid to say about Ebola (NY Times) Enterovirus D68 outbreak (MMWR) Mark Pallansch on EV-D68 (NPR) Enterovirus D68 (CDC) EV-D68 isolation 1962 (Am J Ep) Outbreak of enterovirus 68 (virology blog) Letters read on TWiV 302 Weekly Science Picks

Alan - Index to creationist claims
Rich - Wild Kratts
Kathy - Worn away
Dickson - Iceland volcano eruption
Vincent - Immune Quest

Listener Pick of the Week

Kay - Landes Bioscience open access books

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



174. TWiV 301: Marine viruses and insect defense
http://www.twiv.tv/2014/09/07/... download (audio/mpeg, 57.57Mb)

Description:

Host: Vincent Racaniello

Guests: Carla Saleh and Curtis Suttle

At the International Congress of Virology in Montreal, Vincent speaks with Carla and Curtis about their work on RNA interference and antiviral defense in fruit flies, and viruses in the sea, the greatest biodiversity on Earth.

Links for this episode Greatest biodiversity on Earth (Genome) Cafeteria roenbergensis virus (PNAS) Marine viruses (Nat Rev Micro) RNAi and reverse transcription is antiviral in flies (Nat Imm) Friendly persistent infections (Curr Op Micro) RNAi and antiviral defense in Drosophila (Dev Comp Imm) Video of this episode - view at YouTube

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175. TWiV 300: So happy together
http://www.twiv.tv/2014/08/31/... download (audio/mpeg, 63.70Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

Recording together for the first time, the TWiV team celebrates their 300th recording at the American Society for Microbiology headquarters in Washington, DC, where Vincent  speaks with Dickson, Alan, Rich, and Kathy about their careers in science.

Links for this episode So Happy Together (The Turtles) Viral Hemorrhagic Fever Consortium Support Kenema VHFC program Letters read on TWiV 298 Video of this episode - view at YouTube Weekly Science Picks

Alan - The Internet's Original Sin
Dickson - Placidcoyote
Rich - Scientific Method, Grail Style
Kathy - Viruses Throughout Life and Time
Vincent - ALS Ice Bucket Challenge

Listener Pick of the Week

Jim - iBiology
Victoria - Images of Science
Mehul/Walt - Calling the Shots

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176. TWiV 299: Rocky Mountain virology
http://www.twiv.tv/2014/08/24/... download (audio/mpeg, 59.97Mb)

Description:

Host: Vincent Racaniello

Guests: Marshall BloomSonja Best, and Byron Caughey

Vincent visits the Rocky Mountain Laboratories in Hamilton, Montana and speaks with Marshall, Sonja, and Byron about their work on tick-born flaviviruses, innate immunity, and prion diseases.

Links for this episode Rocky Mountain Laboratories, NIH Flavivirus persistence (Path Dis) Flaviviruses antagonize IRF1 (J Imm) Prion test using nasal brushings (NEJM) Video of this episode - view at YouTube

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177. TWiV 298: MV-NIS de myelo
http://www.twiv.tv/2014/08/17/... download (audio/mpeg, 72.68Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

The TWiV gang answer follow-up questions about the Ebola virus outbreak in West Africa, then discuss treatment of  disseminated multiple myeloma with oncolytic measles virus.

Links for this episode Use of unregistered interventions for Ebola virus disease (WHO) Response to anthrax and H5N1 incidents (CDC) Remission of disseminated cancer after treatment with oncolytic measles virus (Mayo Clin Proc) New viruses for cancer therapy (Nat Rev Micro) Cattaneo on TWiV Image credit Letters read on TWiV 298 Weekly Science Picks

Alan - WTF, Evolution?! by Mara Grunbaum
Rich - Cold Spring Harbor Oral History Collection
Kathy - Inside insides
Vincent - Going Viral (Rocky Mountain Ballet Theatre)

Listener Pick of the Week

Kim - Nobel Prize Podcasts
Johnye - The Planet is Fine
Jennie - Counter-Zombie Dominance Plan (pdf)

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178. TWiV 297: Ebola! Don't panic
http://www.twiv.tv/2014/08/10/... download (audio/mpeg, 78.92Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

The TWiVites present an all-ebolavirus episode, tackling virology, epidemiology, and approaches to prevention and cure that are in the pipeline.

Links for this episode Risks and benefits of gain-of-function experiments (mBio) Scientists for Science US Policy for oversight of DURC (pdf) US framework for guiding H5N1 transmission expts (pdf) Extra oversight for H7N9 experiments (Science) TWiV 283: No Reston for the weary Is it Ebolavirus or Ebola virus? (virology blog) Ebola virus disease update (WHO) Ebola virus disease FAQ (WHO) Ebola hemorrhagic fever (CDC) Ebola virus disease: ecology meets economy (PLoS NTD) 2014 Ebola virus outbreak (J Gen Virol) 2014 Ebola virus outbreak (MMWR) If Ebola virus came to the US (Vox) Zaire ebolavirus in West Africa (interview with Tom Solomon) Why Ebola patients were brought to US (Wash Post) Experimental treatment and vaccines for Ebola (CDC) Aerosol transmission of Reston virus (Sci Rep) Ebola - A growing threat? (NEJM) On the cusp of Ebola vaccine (Know) Ebolavirus vaccines and antivirals (virology blog) Immune responses to Ebolavirus infection (Exp Rev Clin Imm) Antibody therapy for Ebola (Hum Vacc Immunother) Plant derived monoclonals protect macaques from Ebolavirus (PNAS) Anti-ebolavirus monoclonal cocktail (Sci Trans Med) ZMapp info sheet (pdf) ZMapp PR (pdf) High tech treatment for Ebola (ArsTechnica) ZMapp protects macaques (Sci Rep) Letters read on TWiV 297 Weekly Science Picks

Alan - Historical perspective on Ebola (Tara C Smith)
Rich - Tell the negative committee to shut up (Fanuel Muindi)
Kathy - Art of Night (Vimeo)
Vincent - Is Ebola virus going to kill me? (John Skylar)

Listener Pick of the Week

Peter - Dr. Michael Saag interview by Dr. Virginia Campbell
David - PI Predictor (apparticlepublication)

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179. TWiV 296: The real Batman, Linfa Wang
http://www.twiv.tv/2014/08/03/... download (audio/mpeg, 42.88Mb)

Description:

Host: Vincent Racaniello

Guest: Linfa Wang

Vincent visits the Australian Animal Health Laboratory in Geelong, Australia and speaks with Linfa about his work on bats and bat viruses.

Links for this episode Hendra virus vaccine (Emer Inf Dis) Comparison of bat genomes (Science) Endogenous retroviruses in bats (Retrovirol) The Bat Pack Bats in Geelong (YouTube) Video of this episode - view at YouTube

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180. TWiV 295: A nonslip grippe and Lassa's LAMP
http://www.twiv.tv/2014/07/27/... download (audio/mpeg, 74.62Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Rich Condit

The TWiVome discusses an miRNA based strategy to mitigate risk of gain of function studies, and identification of a second receptor required for Lassa virus entry.

Links for this episode

miRNA strategy to minimize risk (Nat BioT) NIH Office of Science Policy NIH recombinant DNA guidelines Second receptor for Lassa virus entry (Science) Lassa fever (Wikipedia) Fever! The discovery of Lassa virus (TWiV 9) Letters read on TWiV 294 Weekly Science Picks

Alan - Nicky Bay macrophotography (Flickr)
Rich - FASEB Third annual BioArt competition
Vincent - Up Close podcast (vrr episode)
Dickson - Science fun (YouTube)

Listener Pick of the Week

Mark Martin - Average bacteriophage
Konrad - Scholarpedia

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181. TWiV 294: Smallpox and anthrax and flu, oh my!
http://www.twiv.tv/2014/07/20/... download (audio/mpeg, 68.17Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Rich Condit

The TWiV team reviews the discovery of old vials of smallpox virus at NIH, anthrax and influenza mishaps at CDC, the baby who was not cured of HIV, Cambridge Working Group, and sacking of NSABB members.

Links for this episode Newly discovered smallpox (CDC) Infectious smallpox in FDA storage (FDA) Report on potential anthrax exposure (pdf, CDC) CDC Director on unsafe practices (NY Times) HIV returns to baby (NY Times) Original HIV baby cured article (NEJM) Cambridge Working Group NSABB members released (ScienceInsider) Letters read on TWiV 294 Weekly Science Picks

Alan - Optivisor
Rich - Noller lab ribosome movies
Vincent - 
Creepy dreadful wonderful parasites
Dickson - National Center for Science Education

Listener Pick of the Week

Mark - The Machinery of Life by David Goodsell
Basel - iBioEducation

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182. TWiV 293: Virology Down Under
http://www.twiv.tv/2014/07/13/... download (audio/mpeg, 63.77Mb)

Description:

Host: Vincent Racaniello

Guests: Melissa ChurchillAlex KhromykhGilda Tachedjian, and Paul Young

Vincent visits Melbourne, Australia and speaks with Melissa, Alex, Gilda, and Paul about their work on HIV infection of the central nervous system, West Nile virus, microbicides for HIV, and the Koala retrovirus.

Links for this episode Where does HIV hide? (Curr Op HIV AIDS) Subgenomic flavivirus RNA (Viruses) Vaginal lactic acid and HIV (J Antimicro Chem) Koala retroviruses (Retrovirology) Coming soon - Video of this episode at YouTube

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183. TWiV 292: Medimmune goes viral
http://www.twiv.tv/2014/07/06/... download (audio/mpeg, 50.13Mb)

Description:

Host: Vincent Racaniello

Guests: Wade Blair, Matt Dickson, Nicole Kallewaard-Lelay, and Ken Miller

Vincent visits Medimmune and speaks with Wade, Matt, Nicole, and Ken about why they work in industry and their daily roles in a biotechnology company.

Links for this episode Medimmune, LLC Medimmune on Twitter Medimmune history and products Video of this episode - view at YouTube

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184. TWiV 291: Ft. Collins abuzz with virologists
http://www.twiv.tv/2014/06/29/... download (audio/mpeg, 45.74Mb)

Description:

Hosts: Vincent RacanielloRich Condit, and Kathy Spindler

Guests: Clodagh O'Shea and Ron Fouchier

Vincent, Rich, and Kathy and their guests Clodagh and Ron recorded this episode at the 33rd annual meeting of the American Society for Virology at Colorado State University in Ft. Collins, Colorado.

Links for this episode Viral polymer that inactivates tumor suppressors (Cell) Mutations driving airborne transmission of influenza H5N1 virus (Cell) Transmission of influenza H7N1 virus in ferrets (J Virol) Ron Fouchier on TWiV #177 Photo credit: Matt Evans Thanks to David Quammen for the title Video of this episode - view at YouTube Weekly Science Picks

Rich - No sexual transmission of HCV (Am J Gastro)
Vincent - Made with code (blog post)
Kathy - Beautiful math images (and 50 Visions of Mathematics)

Listener Pick of the Week

Jon - Advances in Life Sciences winners (YouTube)
Dave - Adam Ruben

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185. TWiV 290: Baylor goes viral
http://www.twiv.tv/2014/06/22/... download (audio/mpeg, 60.48Mb)

Description:

Host: Vincent Racaniello

Guests: Janet Butel and Rick Lloyd

Vincent meets up with Janet Butel and Rick Lloyd at Baylor College of Medicine to talk about their work on polyomaviruses and virus induced stress.

Links for this episode SV40 microRNAs (PLoS Path) SV40 seroprevalence (J Infect) Viruses and stress granules (PLoS Path) Viral inhibition of stress granule formation (Cell Host Micr) Video of this episode - view below or at YouTube

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186. TWiV 289: Vinny and the capsids
http://www.twiv.tv/2014/06/15/... download (audio/mpeg, 69.31Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

Vinny and the capsids answer listener questions about the definition of life, state vaccination laws, the basic science funding problem, viral ecology, inactivation of viruses by pressure, and much more.

Links for this episode Varun's research poll Letters read on TWiV 289 Weekly Science Picks

Alan - The Science of Good Cooking 
Vincent - The Shooter Report (pdf)
Kathy - Daily overview
Dickson - Girl rising

Listener Pick of the Week

Johnye - Ri channel
Ricardo - Open spin microscope (Nikon galleryplans)
Chris - The microbiome game

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187. TWiV 288: ebircsnart esreveR
http://www.twiv.tv/2014/06/08/... download (audio/mpeg, 82.72Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The Twivsters discuss how reverse transcriptase encoded in the human genome might produce DNA copies of RNA viruses in infected cells.

Links for this episode Should variola virus be destroyed? (poll at virology blog) DNA complementary to non-retroviral RNA viruses (Sci Rep) Integration of arenavirus DNA into cell genome (virology blog) Infectious respiratory syncytial DNA (PNAS) Tysabri and PML JC and PML (J Imm Res) Igor Koralnik laboratory Jean-Luc Doumont (Kathy's pick, TWiV 268) Bullet points kill (TED) Letters read on TWiV 288 Weekly Science Picks

Rich - Luvalamps
Alan - Experiment
Vincent - American Society for Virology on Facebook
Kathy - LEGO female scientists
Dickson - The Oldest Living Things in the World by Rachel Sussman

Listener Pick of the Week

Basel - A Treatise on the small-pox and measles by Abu-Bakr Al-Razi

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188. TWiV 287: A potentially pandemic podcast
http://www.twiv.tv/2014/06/01/... download (audio/mpeg, 74.07Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveKathy Spindler, and Matt Frieman

Matt updates the TWiV team on MERS-coronavirus, and joins in a discussion of whether we should further regulate research on potentially pandemic pathogens.

Links for this episode MERS stories at CIDRAP MERS at CDC MERS in the US (CDC) MERS-CoV map MERS-CoV infection after camel exposure (EID) MERS-CoV in dromedaries from Egypt, Sudan, Ethiopia (EID) MERS-CoV antivirals (onetwothreefour) Experiments with novel potential pathogens (PLoS Med) Unacceptable risks (Bull Atom Sci) TWiX Bingo (thanks, Mark!) Letters read on TWiV 287 Weekly Science Picks

Matt - Forgive me, scientists
Alan - 
Do not link
Vincent - bioRxiv
Kathy - Snail photographs
Dickson - Solar roadways

Listener Pick of the Week

Daniel - Benz Biome concept car

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189. TWiV 286: Boston TWiV party
http://www.twiv.tv/2014/05/25/... download (audio/mpeg, 64.96Mb)

Description:

Hosts: Vincent Racaniello and Alan Dove

Guests: Julie Pfeiffer and Paul Duprex

Vincent and Alan meet up with Julie and Paul at the General Meeting of the American Society for Microbiology in Boston, to talk about their work on the pathogenesis of poliovirus and measles virus.

Links for this episode Threading the NEIDL (YouTube) Transmission of measles virus from macaques (J Gen Virol) Tropism of green measles virus in macaques (J Virol) Intestinal microbiota promote enteric virus replication (Science) Bacterial LPS enhances poliovirus stability (Cell Host Micr) Video of this episode - view below or at YouTube Weekly Science Picks

Vincent - ASM Live 2014
Alan - I will not follow the herd
Paul - Invisible Threat
Julie - The importance of stupidity in biological research

Listener Pick of the Week

Neil - WEHI movies and VIZBI

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190. TWiV 285: Hokies go viral
http://www.twiv.tv/2014/05/18/... download (audio/mpeg, 60.84Mb)

Description:

Host: Vincent Racaniello

Guests: XJ Meng and Sarah McDonald

Vincent meets up with XJ and Sarah at Virginia Tech to talk about their work on viruses of swine and rotaviruses.

Links for this episode Hepatitis E virus (Int J Env Res Pub Health) Porcine and human anelloviruses (J Virol) Origin of porcine epidemic diarrhea virus in US (mBio) Distinguishing rotaviruses (J Virol) Molecular epidemiology of rotaviruses  (J Virol) Core domains in rotavirus polymerase encapsidation (J Gen Virol)

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191. TWiV 284: By the pricking of my thumbs, something wicked this way comes
http://www.twiv.tv/2014/05/11/... download (audio/mpeg, 70.66Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierRich Condit, and Kathy Spindler

The TWiV team discusses how skin scarification promotes a nonspecific immune response, and whether remaining stocks of smallpox virus should be destroyed.

Links for this episode Skin scarification protects against vaccinia virus disease (J Virol) Smallpox research agenda (PLoS Path) WHO report on variola research (pdf) Review of smallpox research program for WHO (pdf) How I record my lectures (virology blog) Letters read on TWiV 284 Weekly Science Picks

Rich - EPCOT
Vincent - Medical Biotechnology
Kathy - Alan Alda interview and Flame Challenge winner
Dickson - NASA live from space

Listener Pick of the Week

Nicola - 50 cent microscope (be a beta tester)
Jon - Camtasia Studio

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192. TWiV 283: No Reston for the weary
http://www.twiv.tv/2014/05/04/... download (audio/mpeg, 76.02Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Guest: Jens H. Kuhn

Jens speaks with the TWiV team about filoviruses, including the recent Ebola virus outbreak in Guinea.

Links for this episode Review of Zanamavir clinical trials (Brit Med J) Ebola virus disease in Guinea (NEJM) Filovirus nomenclature (virology blog) Ebola virus disease, West Africa (ProMedMail) How lethal are ebolaviruses? (virology blog) Letters read on TWiV 283 Weekly Science Picks

Alan - AMNH digital special collections
Vincent - Viral entry into host cells (Stefan Pöhlmann PhD, Graham Simmons PhD, eds)
Kathy - Papilloma song lyrics (pdf)
Jens - The Logic of Chance by Eugene V. Koonin

Listener Pick of the Week

Joe - Poor showing of 2012 influenza vaccine (Nature)
Phil - Emerging disease or emerging diagnosis? (YouTube)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



193. TWiV 282: Tamiflu and tenure too
http://www.twiv.tv/2014/04/27/... download (audio/mpeg, 71.90Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

The TWiV team reviews a meta-analysis of clinical trial reports on using Tamiflu for influenza, and suggestions on how to rescue US biomedical research from its systemic flaws.

Links for this episode World Malaria Day Review of oseltamivir clinical trials (Brit Med J) Effectiveness of Tamiflu questioned (NHS choices) Tamiflu campaign (Brit Med J) Rescuing US biomedical research (PNAS) Letters read on TWiV 282 Weekly Science Picks

Alan - Northampton Airport
Vincent - Particle Fever
Kathy - Turn iPhone into microscope
Rich - My favorite science gifs

Listener Pick of the Week

Nathan - The Ascent of Man (YouTube)

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194. TWiV 281: The Salk legacy with Peter L. Salk
http://www.twiv.tv/2014/04/20/... download (audio/mpeg, 62.58Mb)

Description:

Host: Vincent Racaniello

Guest: Peter L. Salk

Vincent meets up with Peter L. Salk to talk about development of the first poliovaccine, eradication of poliomyelitis, and Jonas Salk's 100th birth anniversary.

Links for this episode Jonas Salk Legacy Foundation The Cutter Incident by Paul Offit Splendid Solution by Jeffrey Kluger (review) Coming soon: Video of this episode

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195. TWiV 280: Post viral
http://www.twiv.tv/2014/04/13/... download (audio/mpeg, 67.87Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiVmeisters answer listener email about the NEIDL, negative results, patenting MERS-coronavirus, human papillomavirus transmission, canine distemper virus, and much, much more.

Links for this episode Poxvirus viability in historical relics (EID) TWiM 74: It came from the Siberian permafrost How to read a scientific paper Image credit: Not only quilts Letters read on TWiV 280 Weekly Science Picks

Alan - Heartbleed explanation
Vincent - Agriculture science today podcast
Kathy - Quizlet flashcards (online and iTunes)
Rich - Why nothing is truly alive

Listener Pick of the Week

Lance - Myles Power (YouTube and Facebook)
Raihan - Cheap DIY microscope
Gerald - DaVinci Press
Neal - I'm a virus

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196. TWiV 279: The missing LNC
http://www.twiv.tv/2014/04/06/... download (audio/mpeg, 61.67Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

Vincent, Alan, and Kathy reveal how a retrovirus in the human genome keeps embryonic stem cells in a pluripotent state, from where they can differentiate into all cells of the body.

Links for this episode Retrovirus needed for stem cell identity (Nat Struc Mol Biol) HERV-H is a marker for pluripotency (Retrovirology) Letters read on TWiV 279 Weekly Science Picks

Alan - Heathkit
Vincent - How to think about autism risk and Autism prevalence
Kathy - Distortions

Listener Pick of the Week

Joseph - The real process of science
Marion - Zometool
Kevin - Audioimmunity and Emmunity

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197. TWiV 278: Flushing HIV down the zinc
http://www.twiv.tv/2014/03/30/... download (audio/mpeg, 70.68Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

Vincent, Dickson, Alan, and Kathy discuss disruption of the ccr5 gene in lymphocytes of patients infected with HIV-1.

Links for this episode Gene editing of ccr5 in AIDS patients (NEJM) HIV gets the zinc finger (TWiV 144) Genome engineering with zinc finger nucleases (Genetics) Photo credit: Watty's Wall Stuff Mice lie, monkeys exaggerate t-shirt design (thanks, Christophe) Letters read on TWiV 278 Weekly Science Picks

Alan - Digital scale model of solar system
Dickson - Font of knowledge
Vincent - Measles outbreaks trends, and NYC measles (onetwo)
Kathy - Winner, funding basic science to revolutionize medicine

Listener Pick of the Week

Stephen & Jon - Watty's Wall Stuff
Johyne - Macro views of snowflakes
Ricardo & Stephen - Vaccine exemptions
Bill - Books by John Janovy
Marshall - Animation of DNA replication
Steve - Debunking influenza vaccine myths

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198. TWiV 277: My podcast Vinny
http://www.twiv.tv/2014/03/22/... download (audio/mpeg, 53.86Mb)

Description:

Hosts: Glenn RallAnn Skalka, and Vincent Racaniello

Glenn and Ann meet up with Vincent to talk about his career in science and science communication.

Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



199. TWiV 276: Ramblers go viral
http://www.twiv.tv/2014/03/16/... download (audio/mpeg, 48.19Mb)

Description:

Host: Vincent Racaniello

Guests: Susan Baker and Thomas Gallagher

Vincent meets up with Susan Baker and Tom Gallagher at Loyola University to talk about their work on coronaviruses.

Links for this episode Papain-like viral proteases (Virus Res) MERS-CoV papain-like protease (Virology) Mouse model for MERS-CoV (PNAS) Receptor and MERS-CoV infection (J Virol) Letters read on TWiV 276 Video of this episode - view at YouTube Weekly Science Picks

Vincent - First demonstration of Macintosh, 1984

Listener Pick of the Week

Lance - The Signal and the Noise by Nate Silver

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



200. TWiV 275: Virocentricity with Eugene Koonin
http://www.twiv.tv/2014/03/09/... download (audio/mpeg, 89.25Mb)

Description:

Hosts: Vincent Racaniello and Rich Condit

Guest: Eugene Koonin

Vincent and Rich meet up with Eugene Koonin to talk about the central role of viruses in the evolution of all life.

Links for this episode Virocentric view of evolution (Curr Op Virol) Proposed order Megavirales (Arch Virol) Pithovirus (PNAS) Selfish virus-like elements (Virol J) Pandoraviruses are derived Phycodnaviruses (Biol Direct) Video of this episode - view below at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



201. TWiV 274: Data dump
http://www.twiv.tv/2014/03/02/... download (audio/mpeg, 82.63Mb)

Description:


Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiV team discusses recent cases of polio-like paralysis in California, and the virome of 14th century paleofeces.

Links for this episode MERS-CoV in dromedary camels (EID) Virologist Al Kapikian dies Polio-like illness in CA (ProMedMail) Acute flaccid paralysis AFP in India (EID) Enterovirus 68 (MMWR) EV 68 CNS infection (Arch Path Lab Med) Polio-free does not mean paralysis-free (The Hindu) Viruses in 14th century coprolite (AEM) Coprolite and paleofeces Ancient poxvirus (EID) Giant coprolite (WordADay) Letters read on TWiV 274 Weekly Science Picks

Alan - The science of science communication
Rich - Command and Control by Eric Schlosser
Dickson - Top 10 plant viruses
Vincent - Is the Nobel Prize good for science?
Kathy - Time to rethink graduate and postdoc education (YouTube)

Listener Pick of the Week

Jon - Lessons from a Kansas graveyard
Mike -  Cross a fashion designer with a microbiologist

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



202. TWiV special: MERS-coronavirus in dromedary camels
http://www.twiv.tv/2014/02/25/... download (audio/mpeg, 26.42Mb)

Description:

Host: Vincent Racaniello

Guests: W. Ian Lipkin and Thomas Briese

Vincent meets up with Ian and Thomas to discuss their finding that MERS-coronavirus has been circulating in dromedary camels in the Kingdom of Saudi Arabia since at least 1992.

Links for this episode MERS-CoV in dromedary camels (mBio)
TWiV 251: Don't kiss the camel TWiV 247: Today's weather in virology TWiV 239: Filterable camels

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



203. TWiV 273: Lambda is not just a phage
http://www.twiv.tv/2014/02/23/... download (audio/mpeg, 71.21Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierRich Condit, and Kathy Spindler

The TWiVome dissect the finding that interferon lambda alleles predict the outcome of hepatitis C virus infection.

Links for this episode Interferon lambda and HCV outcome (Cell Host Micr) Laser capture microdissection (Wikipedia) HCV dependent fluorescent reporter (Nat Biotech) Bats and viruses (PLoS Path) White nose syndrome (PLoS Path) Mouse phenome database Letters read on TWiV 273 Weekly Science Picks

Rich - Think like a scientist (onetwo); Science controversies
Dickson - Visualization challenge 2013
Vincent - Orphan Black
Kathy - Alberta worm invasion project

Listener Pick of the Week

Timothy - How do vaccines cause autism?
Anne - Luke Jerram's glass viruses
Jim - NLM Communications Engineering Branch
Steve - Synapse by synapse
J
acob - Tiny technology creates a buzz

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



204. TWiV 272: Give peas a chance
http://www.twiv.tv/2014/02/16/... download (audio/mpeg, 74.35Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiV team describes aphid control by using a viral capsid protein to deliver a spider toxin to plants, and a human endogenous retrovirus that enhances expression of a neuronal gene.

Links for this episode Toxin delivery to plants by viral capsid protein (Nat Biotech) Pea enation mosaic virus (ViralZone) Image credit: Aphid membrane feeding chamber (Sci Rep) Aphid feeding chamber (YouTube) Parafilm (Wikipedia) Human endogenous retrovirus enhances neural gene (PNAS) Flu, common cold, alternative medicine (NCCAM) Cold vs flu (CDC) Phage hunters Bed bugs and infectious disease (PLoS Path) Letters read on TWiV 272 Weekly Science Picks

Alan - Statistical error (Nature)
Rich - 12 oldest animal species
Dickson - When liquids collide
Vincent - HIV denial and just asking questions
Kathy - Sun's canyon of fire

Listener Pick of the Week

Sandra - Women physicists keep female students psyched
Judi - HHMI's Biointeractive
Jacob - Influenza virus HA

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



205. TWiV 271: To bee, or not to bee, that is the infection
http://www.twiv.tv/2014/02/09/... download (audio/mpeg, 66.18Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Ashlee Bennett

The TWiV crew discusses two reports on viruses that might have crossed kingdoms, from plants to honeybees and from plants to vertebrates.

Links for this episode Tobacco ringspot virus in honeybees (mBio) Plant virus that switched to vertebrates (PNAS) CDC influenza activity and surveillance With Esmeralda at ASM Biodefense (jpg) Image credit: Virginia Tech Learning Resources Center Letters read on TWiV 271 Weekly Science Picks

Alan - Nagasaki bombing (YouTube)
Rich - GoPro Red Bull Stratos (YouTube)
Dickson - Solar orbs
Vincent - Socrative

Listener Pick of the Week

Basel - Pathology course online
Russell - Sochi 2014: Encyclopedia of spending
Yegor - Visual Science

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



206. TWiV 270: Homeland virology
http://www.twiv.tv/2014/02/02/... download (audio/mpeg, 58.16Mb)

Description:

Hosts: Vincent Racaniello and Rich Condit

Guests: Dennis Hruby and Yoshihiro Kawaoka

Vincent and Rich discuss avian influenza virus and an antiviral drug against smallpox with Dennis and Yoshi at the ASM Biodefense and Emerging Diseases Research Meeting in Washington, DC.

Links for this episode ASM Biodefense Meeting Influenza H5N1 transmission (Virus Res) Aerosol transmission of H5N1 virus in ferrets (Nature) Characterization of H7N9 virus from humans (Nature) ST-246 efficacy in primates (AAC) Antiviral options for biodefense (Curr Op Virol) ST-246 safety in humans (Antimicrob Agents Chemother) Gain-of-function experiments (Science) Letters read on TWiV 270 Video of this episode - view at Vimeo Weekly Science Picks

Vincent - Quanta Magazine
Rich - Colour is in the eye of the beholder

Listener Pick of the Week

Kehau - Beautiful but deadly viruses

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



207. TWiV 269: Herpesvirus stops a nuclear attack
http://www.twiv.tv/2014/01/26/... download (audio/mpeg, 70.52Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The complete TWiV team reviews evidence for sensing of herpesviral DNA in the nucleus by the cell protein IFI16. 

Links for this episode IFI16 is a nuclear pathogen sensor (Cell Host Micr) Nuclear IFI16 sensing of and antagonism by herpesvirus (PNAS) Acetylation regulates IFI16 location (PNAS) Letters read on TWiV 269 Weekly Science Picks

Kathy - Female conveners and speakers
Alan - Sandgrains
Rich - 2013 Lamborghini Aventador
Vincent - Happy Birthday Mac and 128K Mac teardown
Dickson - Farmdominion

Listener Pick of the Week

Peter - The Microscope and The Next Global Killer
Richard - Glass viruses

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



208. TWiV 268: Transmission is inevitable
http://www.twiv.tv/2014/01/19/... download (audio/mpeg, 73.06Mb)

Description:

Hosts: Vincent RacanielloAlan DoveKathy Spindler, and Ashlee Bennett

Vincent, Alan, Kathy, and Ashlee discuss fomites in physicians offices, plant virus factories involved in aphid transmission, and clues from the bat genome about flight and immunity.

Links for this episode How viruses cause disease (Coursera) How clean is your iPad (Which?) Meeting announcement: From emerging to pandemic viruses CaMV virus factories involved in aphid transmission (J Virol) Caulimovirus (ViralZone) CaMV responds instantly to vector (eLIFE) Aphid acquiring CaMV (J Virol) Bat genomes, flight, and immunity (Science) Letters read on TWiV 268 Weekly Science Picks

Kathy - Jean-Luc Doumont (slidescommunicating science, website, Scitable)
Alan - Wireless thermometer
Vincent - LORiOLA viral necklaces

Listener Pick of the Week

Jessica - Knit icosahedron
Robert - Practical computing for biologists by Haddock and Dunn
Stephen - Fourteen years of US weather (YouTube)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



209. TWiV 267: Snow in the headlights
http://www.twiv.tv/2014/01/12/... download (audio/mpeg, 65.56Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Vincent, Alan, Rich and Kathy review a protease essential for influenza pathogenesis in mice, and directionality of rhinovirus RNA exit from the capsid.

Links for this episode Protease essential for influenza pathogenesis in mice (PLoS Path) Rhinovirus uncoating is directional (PLoS Path) Fluorescence correlation spectroscopy Capillary electrophoresis (Wiki) Letters read on TWiV 267 Weekly Science Picks

Kathy - Amazing maps
Alan - Florida to NJ in 156 seconds (YouTube)
Rich - Whiteout over Great Lakes from Space
Vincent - LORiOLA viral necklaces

Listener Pick of the Week

Carol - Knit picornavirus
Robert - RNA: Life's Indispensible Molecule by James Darnell,
and Biochemical Pathways by Michal and Schomburg

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



210. TWiV 266: A pathogenic vicious cycle
http://www.twiv.tv/2014/01/05/... download (audio/mpeg, 66.79Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

Vincent, Alan, and Kathy discuss finding viruses in outer space, varying results obtained from personal genetic testing, and depletion of CD4 cells during HIV infection by pyroptosis.

Links for this episode We should hunt for viruses in space (New Scientist) I had my DNA picture taken (NY Times) CD4 cell death by pyroptosis (Nature) Abortive HIV infection in lymphoid tissue (Cell) IFI16 sensor required for HIV mediated cell death (Science) PubMed Commons Preferential CTL targeting of Gag (Cell Rep) Exonic transcription protein binding (Science) Letters read on TWiV 266 Video of this episode - view at YouTube Weekly Science Picks

Kathy - 17 mundane things, mind blowing views
Alan - Snowovel
Vincent - Public's views on human evolution

Listener Pick of the Week

Emily - Dengue pillow 

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



211. TWiV 265: This year in virology
http://www.twiv.tv/2013/12/29/... download (audio/mpeg, 71.21Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

In their final episode of the year, the TWiV team reviews ten compelling virology stories from 2013.

Links for this episode Antiviral RNAi (TWiV 255256263) MERS-CoV (TWiV 215223224233239247251258) Placental trophoblasts confer viral resistance (TWiV 241) Origin of REV (TWiV 248) Phage T7 gets a cat scan (TWiV 220) It's a cGAS! (TWiV 222) Dual virus-host arms race (TWiV 242) Pandoraviruses (TWiV 246261) CMV based SIV vaccine (TWiV 254) Threading the NEIDL Letters read on TWiV 265 Video of this episode - view at YouTube Weekly Science Picks

Kathy - Women in Science
Alan - Contagium
Rich - RC helicopter (demo)
Vincent - The athletic power of quadcopters

Listener Pick of the Week

Lindsay - Alcohol consumption and vaccines (Vaccine)
Johnye - The Singing Microbiologist

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



212. TWiV 264: We should do an all-email show some day
http://www.twiv.tv/2013/12/22/... download (audio/mpeg, 68.97Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

The TWiVites read listener questions and comments about public engagement in science, vaccines, RNAi, reprogramming CD8 cells to treat cancer, rabies, and much more.

Links for this episode Viral gifts Controlling plant viruses by vector control (Ann Rev Phyto) Flavivirus RNAi suppressor (J Virol) Entre probetas podcast (iTunes) Hedgehog central Reprogramming T cells for leukemia therapy (NEJM) Petri Dish podcast On Your Mind podcast Letters read on TWiV 264 Weekly Science Picks

Kathy - Sorting algorithms visualized
Alan - Stratodean
Rich - Art in Science by Polyxeni Potter
Vincent - Pixel Genes

Listener Pick of the Week

Judi - Olympus BioScapes Winner

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



213. TWiV 263: Game of clones
http://www.twiv.tv/2013/12/15/... download (audio/mpeg, 71.39Mb)

Description:

Hosts: Vincent Racaniello, Dickson Despommier, Alan DoveRich ConditKathy Spindler, and Ben tenOever

Ben joins the TWiV team to reveal the winner of his contest in which influenza viruses carrying different interferon-stimulated genes vie against one another in mice.

Links for this episode Virusninja Game of clones (Vax Rep) Game of clones bracket Letters read on TWiV 263 Weekly Science Picks

Kathy - The Brain Scoop, esp. Where My Ladies At
Alan - Say 'hi' to a spaceship (YouTube)
Rich - Garmin BlueChart Mobile and Active Captain
Vincent - Journal boycott (onetwo)
Dickson - Futurescape TV show

Listener Pick of the Week

Luis - Spillover by David Quammen
Ken - Gravity

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



214. TWiV 262: Wrong form, right professor
http://www.twiv.tv/2013/12/08/... download (audio/mpeg, 65.99Mb)

Description:

Host: Vincent Racaniello

Guest: Ann Palmenberg

Vincent returns to the University of Wisconsin - Madison to speak with Ann Palmenberg about her career in virology.

Links for this episode Palmenberg lab website - great resources Genome sequences of all rhinoviruses (J All Clin Imm) Cardioviral poly(C) tracts (Arch Virol Supp) EMCV disruption of nuclear transport (PNAS) Picornavirus protease in replicase gene (J Virol) Bacteriophage Qbeta replicase (J Virol) Thanks to Jordan for the episode title! Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



215. TWiV 261: Giants among viruses
http://www.twiv.tv/2013/11/30/... download (audio/mpeg, 49.90Mb)

Description:

Hosts: Vincent Racaniello and James Van Etten

Guests: Chantal Abergel and Jean-Michel Claverie

Vincent meets up with Chantal and Jean-Michel at the first International Symposium on Giant Virus Biology in Tegernsee, Germany, to discuss their work on Mimivirus, Megavirus, and Pandoravirus.

Links for this episode Unanswered giant virus questions (Adv Virus Res) Fourth domain of life (Commun Integr Biol) Pandoraviruses (Science) Phaeocystis globosa virus (PNAS) Cafeteria roenbergensis virus (PNAS) Symposium group photo (jpg) Video of this episode - view at YouTube

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216. TWiV 260: Badgers go viral
http://www.twiv.tv/2013/11/24/... download (audio/mpeg, 65.63Mb)

Description:

Host: Vincent Racaniello

Guests: Tom FriedrichTony Goldberg, and David O'Connor

Vincent visits the University of Wisconsin, Madison and speaks with Tom, Tony, and David about their work on virus discovery at the AIDS Vaccine Research Laboratory.

Links for this episode A tick in Tony's nose (Am J Trop Med Hyg) Two new SIV from colobus monkeys in Uganda (Biomed Cent) Pegivirus diversity in Uganda (J Gen Virol) Simian hemorrhagic fever virus diversity in African primates (J Virol) Video of this episode - coming soon

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



217. TWiV 259: Windows into the soul of a cell
http://www.twiv.tv/2013/11/16/... download (audio/mpeg, 59.84Mb)

Description:

Hosts: Vincent Racaniello and Rich Condit

Guest: Jaquelin Dudley

Vincent and Rich join Jackie at the University of Texas, Austin to talk about her work on mouse mammary tumor virus.

Links for this episode Rem signal peptide processing and function (J Virol) MMTV null mice and tumorigenesis (J Virol) Jackie's publications (PubMed) I want my MMTV (TWiV 242) Live at ASV in Madison (TWiV 193) Symbiotic safecrackers (TWiV 154)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



218. TWiV 258: Hedging our bats
http://www.twiv.tv/2013/11/10/... download (audio/mpeg, 59.13Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich ConditKathy Spindler, and Matt Frieman

Matt joins the TWiV team to discuss the discovery of a SARS-like coronavirus in bats that can infect human cells, and what is going on with MERS-coronavirus.

Links for this episode SARS-like virus in bats binds ACE2 (Nature) Bat SARS-like virus that infects human cells (virology blog) Coronavirus infections update (WHO) Lack of MERS coronavirus antibodies in humans (EID) Mice not susceptible to MERS-CoV (J Gen Virol) MERS-CoV case imported into Spain MERS-CoV like virus in European hedgehogs (J Virol) DPP4 amino acids positively selected in bats (Virol J) Image credit: Richie Frieman Letters read on TWiV 258 Weekly Science Picks

Kathy - Optical illusion (YouTube)
Alan - Amboceptor
Matt - Reply all by Richie Frieman (audio sample)
Vincent - The microbiology of beer

Listener Pick of the Week

Cassie - NeatoShop
Peter - Synapse evolution with Seth Grant (BSP 101)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



219. TWiV 257: Caveat mTOR
http://www.twiv.tv/2013/11/03/... download (audio/mpeg, 70.07Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The TWiV team consider how the kinase mTOR modulates the antibody response to provide broad protection against influenza virus, and explore the problems with scientific research.

Links for this episode Two lives intertwined (Ann Rev Imm) John Holland, 83 Kinase mTOR modulates antibody response (Nat Imm) Drug widens immunity to flu (TheScientist) Concerto in B (TWiV 161) How science goes wrong (Economist) Trouble at the lab (Economist) Reforming science (TWiV 184) Letters read on TWiV 257 Weekly Science Picks

Dickson - Tesla Motors supercharger
Kathy - FASEB contest: Stand out for science
Alan - Natural History Museum virtual tour
Rich - Mauna Kea heavens
Vincent - FAA expands use of electronics on planes

Listener Pick of the Week

Peter - Score and ignore (pdf)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



220. TWiV 256: How mice say nodavirus
http://www.twiv.tv/2013/10/27/... download (audio/mpeg, 66.29Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

Vincent, Dickson, Alan, Rich, and Kathy review two papers that present evidence for RNA interference as an antiviral immunity mechanism in mammals.

Links for this episode: World Polio Day Mole Day John Holland's publications RNAi is antiviral in mammals (Science) Antiviral RNA interference in mammals (Science) RNAi, antiviral after all (Science) Is RNA interference antiviral in mammals? (Cell Host Microbe) Nodamura virus (Nature) Ebolavirus proteins suppress RNAi (J Virol) Illustrated is an siRNA (orange), dicer (top right), and argonaute (bottom) Letters read on TWiV 256 Weekly Science Picks

Dickson - Wildlife Photographers of the Year 2013
Kathy - John Holland's Emerging Infectious Disease lecture (YouTube)
Alan - The worst part is not
Rich - The Universe in a Single Atom by Dalai Lama (Mind and Life Institute)
Vincent - The Truth about T. Rex by Brian Switek

Listener Pick of the Week

Stephen - International Institute for Species Exploration (Top 10 species choice

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



221. TWiV 255: Longhorns go viral
http://www.twiv.tv/2013/10/20/... download (audio/mpeg, 51.07Mb)

Description:

Hosts: Vincent Racaniello and Rich Condit

Guests: Robert Krug and Christopher Sullivan

Vincent and Rich visit the University of Texas at Austin and meet up with Bob and Chris to talk about their work on influenza virus and microRNAs.

Links for this episode: Virus-encoded microRNAs (PLoS Path) microRNA targetomes of polyomavirus (J Virol) Innate and RNAi reciprocal inhibition (Cell) ISG15 pathway (Trends Micro) Role of viral NS1 protein (Virology) Cap-snatching (Cell) Weekly Science Picks

Rich - Unraveling Bolero
Vincent - New botulinum toxinDURC implications, and inconvenient truths

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



222. TWiV 254: Ninety-nine macaques on the wall
http://www.twiv.tv/2013/10/13/... download (audio/mpeg, 65.56Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and Kathy Spindler

Vincent, Dickson, Alan, and Kathy review clearance of simian immunodeficiency virus infection from macaques by immunization with SIV proteins encoded in a rhesus cytomegalovirus vector.

Links for this episode: Immune clearance of SIV infection (Nature) Rhesus CMV vectors (Nature Medicine) Types of memory T cells (WikiPedia) Goldilocks approach to vaccines (Scilogs) Chimeric HA influenza vaccine (J Virol) Influenza vaccine matched vs mismatched (BMC Medicine) Letters read on TWiV 254 Weekly Science Picks

Dickson - The Man Who Planted Trees by Jean Giono
Kathy - A boy and his atom and Moving Atoms (YouTube)
Alan - It is pitch dark and Get Lamp (YouTube)
Vincent - Who's afraid of peer review? (Science)

Listener Pick of the Week

Maren - Hello Maestro (episodes on YouTube)
Ayesha - Why you don't f****** love science
Jon - A Capella Science (YouTube)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



223. TWiV 253: I don't know anything about sorghum
http://www.twiv.tv/2013/10/06/... download (audio/mpeg, 95.98Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

In this second consecutive all-email episode, the complete TWiV team reads questions and comments from listeners about systemic antiviral responses, wild type poliovirus in Israel, Turkish scientists, viral symbiotes, and much more.

Links for this episode: One Nation in support of biomedical research? Bilim Kazani (The Cauldron of Science) Science for Gezi State of Turkish Science Pathogenesis of feline coronavirus (EID) Dinosaurs plagued by infection (PLoS One) Dinosaur renaissance (WikiPedia) Birds are dinosaurs (AMNH) Influenza vaccine enhances disease in pigs (Sci Transl Med) Gut microbes influence B-cell development (Nature) Circovirus in dogs (EID) We the microbiologist Letters read on TWiV 251 Weekly Science Picks

Dickson - HD slow motion montage (YouTube)
Kathy - Damselflies and Eyewitness app
Alan - Space weather forecast (YouTube)
Rich - 1984 by George Orwell (Doublethink)
Vincent - PopSci comments off and Why so few women in science?

Listener Pick of the Week

Meika - Flip action roll (YouTube)
CN - Blink: The Power of Thinking without Thinking by Malcolm Gladwell
Bernadeta - Higgs Boson wins Nobel Prize

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



224. TWiV 252: Who read the last email?
http://www.twiv.tv/2013/09/29/... download (audio/mpeg, 69.22Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The complete TWiV team reads email from listeners about anti-vaccine activists, a career in microbiology, placentas, a virology textbook, the HeLa cell genome, norovirus, and much more.

Links for this episode: Anthropic principle 1999 vaccine article by Alan Dove (Nature) Image credit: Jason Roberts Letters read on TWiV 251 Weekly Science Picks

Dickson - A Sand County Almanac by Aldo Leopold
Kathy - Noctilucent clouds and aurora over Scotland
Alan - Flu vaccination map
Rich - There's a fly in my urinal
Vincent - Picornaviridae.com

Listener Pick of the Week

Peter - PDB-101
Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



225. TWiV 251: Don't kiss the camel
http://www.twiv.tv/2013/09/22/... download (audio/mpeg, 67.80Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The complete TWiV crew reviews work on MERS-coronavirus, including serological studies in camels, production of an infectious DNA clone, and identification of an interferon antagonist.

Links for this episode: Stephan Chron dies (NY Times) Philip Marcus dies (NY Times) Philip Marcus on TWiV #197 Ellen Fanning dies (news@Vanderbilt) Donald Low dies (CBC News) MERS timeline MERS-CoV seroepidemiology (Eurosurveillance) MERS-CoV neutralizing antibodies in camels (Lancet Inf Dis) MERS-CoV vaccine candidate (mBio) MERS-CoV infectious DNA (PNAS) MERS-CoV protein 4a is IFN antagonist (J Virol) Letters read on TWiV 251 Weekly Science Picks

Dickson - Scharf Photo
Kathy - Blaschka glass models (NY TimesCornell)
Alan - Digital Public Library of America
Rich - Dengue virus life cycle animation
Vincent - Creative Live

Listener Pick of the Week

John - Last person to get smallpox (NPR)
Peter - SARS documentary (BBC)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



226. TWiV 250: Wookie viruses
http://www.twiv.tv/2013/09/15/... download (audio/mpeg, 63.52Mb)

Description:

Hosts: Vincent Racaniello and Robert Garcea

Vincent and Robert recorded this episode at the 53rd ICAAC in Denver, where they talked about polyomaviruses.

Links for this episode: A cornucopia of human polyomaviruses (Nat Rev Micro) Polyoma assembly factories in nucleus (PLoS Path) Overprinting gene in Merkel cell polyomavirus (PNAS) Human JCV as population marker (PLoS One) Letters read on TWiV 250 Video of this episode (YouTube) Weekly Science Picks

Robert - The Panic Virus by Seth Mnookin
Vincent - Aliens chestburster behind the scenes

Listener Pick of the Week

Adam - Virology Fact of the Day
Christophe - dr Karl

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



227. TWiV 249: An inordinate fondness for viruses
http://www.twiv.tv/2013/09/08/... download (audio/mpeg, 62.58Mb)

Description:

Hosts: Vincent RacanielloDickson Despommier, Alan Dove, and Rich Condit

Vincent, Dickson, Alan and Rich discuss an estimate of the number of different mammalian viruses on Earth.

Links for this episode: Estimate of unknown viral diversity in mammals (mBio) How many viruses on Earth? (virology blog) Letters read on TWiV 249 Weekly Science Picks

Alan - Extreme macrophotography
Dickson - Baloney detection kit
Rich - Mutant silkworms spin colored silk (original article)
Vincent - FlightRadar24

Listener Pick of the Week

Jenn - Ebola by William Close
Jenn - Eleven Blue Men by Berton Roueche
Nissin -Profiles in Science

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



228. TWiV 248: TWiP infects TWiV
http://www.twiv.tv/2013/09/01/... download (audio/mpeg, 71.03Mb)

Description:

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

Vincent, Dickson, and Rich reveal how experiments with a malaria parasite lead to the introduction of a mammalian retrovirus into birds.

Links for this episode: Scientists cast doubt on MERS origin (NY Times) Animal reservoirs of SARS coronavirus (Virus Res) Jo Handelsman in the White House Origins of REV (PLoS Biology) Inadvertent transfer (virology blog) Mongoose, pheasant, pox, retrovirus (PLoS Biol) Evolutionary history of REVs Amazing story (Ed Yong) My wife's P. lophurae paper (Mol Bio Parasitol) William Trager's SNV paper (Exp Biol Med) EBV detection tests (Clin Diag Lab Immunol) Letters read on TWiV 248 Weekly Science Picks

Dickson - Google Sky
Rich - Vanishing of the Bees (see also Bee Apocalypse Now)
Vincent - Not Exactly Rocket Science

Listener Pick of the Week

Saira - Reproducibility Initiative

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



229. TWiV 247: Today's weather in virology
http://www.twiv.tv/2013/08/25/... download (audio/mpeg, 75.97Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Special guest: Ian Lipkin

Ian joins Vincent, Alan, Rich, and Kathy to describe how his laboratory is searching for the origin of MERS-coronavirus.

Links for this episode: MERS-CoV in bats (EID) Mystery virus (NY Times) Part of MERS-CoV found in bat (virology blog() T. perforatus Frag virus (Virol J) Even Nature got it wrong! (Nature) Bats: Important reservoirs of emerging viruses (Clin Micro Rev) Letters read on TWiV 247 Weekly Science Picks

Kathy - Rainbows explained (Frazz)
Alan - Challenge.gov
Vincent - 23andme
Rich - Spot the station

Listener Pick of the Week

Frank - Pacifier cleaning practices and risk of allergy development (Pediatrics)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



230. TWiV 246: Pandora, pandemics, and privacy
http://www.twiv.tv/2013/08/18/... download (audio/mpeg, 59.54Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Vincent, Alan, Rich, and Kathy discuss the huge Pandoravirus, virologists planning H7N9 gain of function experiments, and limited access to the HeLa cell genome sequence.

Links for this episode: Pandoraviruses (Science) Unlike anything seen before (virology blog) H7N9 gain of function experiments planned (NatureScience) Virologists plan H7N9 gain of function experiments (virology blog) Creating a deadly virus? Not!! (USA Today) HeLa cell genome sequence (Nature) NIH Director explains HeLa agreement (Nature) HeLa deal (Nature) Biospecimen policy (Nature) Sequencing HeLa the right way (turbidplaque) Skloot on HeLa deal (The Scientist) HeLa deal (NY TimesUSA Today) Picture on Condit's wall (EID) Letters read on TWiV 246 Video of this episode - view below or at YouTube  Weekly Science Picks

Kathy - GeoGuesser
Alan - From one, many (YouTube)
Vincent - Dave Bhella: The Wildy Award Talk (Microbeworld video)
Rich - 1981 primitive internet report (YouTube)

Listener Pick of the Week

CN - How the Mind Works by Steven Pinker

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



231. TWiV 245: Writing Principles of Virology
http://www.twiv.tv/2013/08/11/... download (audio/mpeg, 43.77Mb)

Description:

Host: Vincent Racaniello

Guests: S. Jane Flint, Lynn Enquist, Glenn Rall, and Ann Skalka

The authors of the popular textbook Principles of Virology discuss how the book was conceived and written.

Links for this episode: Principles of Virology Lahiere's General Virology by SE Luria

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232. TWiV 244: Back in the CVVR
http://www.twiv.tv/2013/08/04/... download (audio/mpeg, 56.86Mb)

Description:

Hosts: Vincent Racaniello and Alan Dove

Guests: Dan Barouch and Jeff Teigler

This episode of TWiV was recorded before an audience at the Beth Israel Deaconess Medical Center, where Vincent and Alan spoke with Dan and Jeff about AIDS vaccines.

Links for this episode: Human study of adenovirus 26 HIV-1 envelope vaccine (J Inf Dis) Seroepidemiology of adenovirus serotypes (Vaccine) SIV infection associated with expansion of gut virome (Cell, TWiV #204) Global approach to HIV-1 vaccine development (Immunol Rev) Innate cytokine responses to adenoviruses (J Virol) microRNAs as mediators of viral evasion (Nat Immunol) Letters read on TWiV 244
Weekly Science Picks

Jeff - Science in the News; How to succeed in science (part one and part two)
Alan - Nanostructure flowers
Vincent - Scientific culture

Listener Pick of the Week

Basel - The sequester blues

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



233. TWiV 243: Live from ASV at Penn State
http://www.twiv.tv/2013/07/28/... download (audio/mpeg, 48.12Mb)

Description:

Hosts: Vincent RacanielloRich Condit, and Kathy Spindler

Guests: Rebecca Dutch and Christiane Wobus

On this episode of TWiV, which was recorded before a large enthusiastic audience at the annual meeting of the American Society for Virology, Vincent, Rich, and Kathy speak with Rebecca and Christiane about their work on metapneumoviruses and noroviruses.

Links for this episode: TWiV 143 with Stephanie Karst American Society for Virology Mouse model for human norovirus (mBio) Paramyxovirus fusion (Viruses) Photo credit: Matt Evans Weekly Science Picks

Kathy - Shuffling cards
Vincent - Dave Bhella - Electron cryomicroscopy
Rich - Seven-year postdoc

Listener Pick of the Week

Judi - Reading for science literacy

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



234. TWiV 242: I want my MMTV
http://www.twiv.tv/2013/07/21/... download (audio/mpeg, 64.30Mb)

Description:

Hosts: Vincent RacanielloDickson DespommierAlan DoveRich Condit, and Kathy Spindler

The complete TWiV team talks about how two different viruses shape the evolution of an essential housekeeping protein.

Links for this episode: Dual virus-host arms race (PLoS Biology) Dual virus-receptor duel (see comments - virology blog) Ferritin and transferrin (Protein Data Bank) Money for nothing (YouTube) Letters read on TWiV 242 Weekly Science Picks

Dickson - Mantid images
Kathy - No email? (phd comics)
Alan - The turbid plaque
Vincent - AAM Faq: West Nile Virus
Rich - Science is awesome

Listener Pick of the Week

Luis - Public Health Image Library
Stephen - Hopkins closes graduate science-writing program

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



235. TWiV 241: The ferret looks ill
http://www.twiv.tv/2013/07/14/... download (audio/mpeg, 69.61Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Vincent, Alan, Rich and Kathy review how human placental trophoblasts confer viral resistance via exosome-mediated delivery of microRNAs, and isolation of the first human influenza virus in 1933.

Links for this episode:

Human placental trophoblasts confer viral resistance (PNAS) Placental circulation (Wikipedia) Ovum in uterine decidua (Wikipedia) A virus obtained from influenza patients (Lancet) 80 years ago today (the guardian) Influenza: Exposing the true killer (J Exp Med) Letters read on TWiV 239 Weekly Science Picks

Matt - The Kid Should See This
Alan - Cassini to photograph Earth 
Vincent -Cockroaches! (YouTube)
Rich - Sydney Brenner (Web of Stories)

Listener Pick of the Week

Joe - Grand challenges in science education (Science)
Mark - Weather Underground

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



236. TWiV 240: Virology in Vermont
http://www.twiv.tv/2013/07/07/... download (audio/mpeg, 51.18Mb)

Description:

Host: Vincent Racaniello

Guests: Markus Thali and Jason Botten

Vincent travels to the University of Vermont to talk with Markus and Jason about their work on HIV, influenza virus, arenaviruses and hantaviruses.

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



237. TWiV 239: Filterable camels
http://www.twiv.tv/2013/06/30/... download (audio/mpeg, 70.20Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, Rich Condit, and Matt Frieman

Matt joins Vincent, Alan, and Rich to summarize what we know and what we do not know about the MERS coronavirus.

Links for this episode: MERS-CoV update (WHO) MERS-CoV evolution (epidemic) Sick camel linked to MERS-CoV death (7Days) MERS-CoV hospital outbreak (NEJM) MERS-CoV French hospital cluster (Lancet) MERS-CoV family cluster (NEJM) Matt on MERS-CoV on the Voice of Russia Letters read on TWiV 239 Weekly Science Picks

Matt - The Kid Should See This
Alan - Cassini to photograph Earth 
Vincent -Cockroaches! (YouTube)
Rich - Sydney Brenner (Web of Stories)

Listener Pick of the Week

Ebrahim - Virus Hunter by CJ Peters and Mark Olshaker

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



238. TWiV 238: Lost in translation
http://www.twiv.tv/2013/06/23/... download (audio/mpeg, 69.47Mb)

Description:

Hosts: Vincent RacanielloRich Condit, and Kathy Spindler

Vincent, Rich and Kathy discuss mechanisms of protein synthesis and regulation in virus-infected cells.

Links for this episode: Slides for this episode (pdf) T7 ribosomal binding sites (CSH Symp Quant Biol) Tinkering with translation (CSH Persp) Translation at nexus of infection and immunity (Cell Host Microbe) Viral subversion of protein synthesis machinery (Nat Rev Micr) Weekly Science Picks

Kathy - Vaccine-preventable outbreaks
Rich -  To Catch a Virus by John Booss and Marilyn J. August
Vincent - This is Water by David Foster Wallace

Listener Pick of the Week

Jon - Confessions of a converted lecturer by Eric Mazur
Peter - FameLab

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



239. TWiV 237: Paleovirology with Michael Emerman
http://www.twiv.tv/2013/06/16/... download (audio/mpeg, 56.08Mb)

Description:

Hosts: Vincent Racaniello and Rich Condit

Guest: Michael Emerman

Vincent and Rich recorded this episode at the Fred Hutchinson Cancer Research Center in Seattle, WA, where they met up with Michael to talk about his work on the molecular and evolutionary basis of HIV replication and pathogenesis.

Links for this episode:  Ancient origins of SIV (PLoS Path) Paleovirology (PLoS Biology) Harmit Malik on TWiV 205 Sara Sawyer on TWiV 193 Listener Pick of the Week

Molly - Facts in the case of Dr. Andrew Wakefield

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240. TWIV 236: Flu gets the VIP treatment
http://www.twiv.tv/2013/06/09/... download (audio/mpeg, 61.39Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

Vincent, Alan and Kathy review novel approaches to preventing influenza virus infection.

Links for this episode: Ultraprotective influenza vaccine in mice (PNAS) Vectored immunoprophylaxis of influenza in mice (Nat Biotech) Intranasal antibody gene transfer protects agains influenza (Sci Transl Med) Estimating influenza associated deaths (CDC) Multistate HAV outbreak (CDC) Subscribe to Microbeworld video (YouTube) Save podcasting (EFF) Letters read on TWiV 236 Weekly Science Picks

Alan - Psychology of antivaccinationists
Vincent -  Virology on Coursera
Kathy - Meteorites through the ages

Listener Pick of the Week

Basel - Self-medication in animals
Sheryl - Noadi's art
Felicity - Survival of the Sickest by Sharon Moalem

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



241. TWiV 235: Live in Edmonton, eh?
http://www.twiv.tv/2013/06/02/... download (audio/mpeg, 53.04Mb)

Description:

Hosts: Vincent Racaniello and Rich Condit

Guests: Dave EvansStan Lemon, and Lorne Tyrrell

Vincent and Rich recorded this episode before an audience at the 2nd Li Ka Shing Institute of Virology Symposium at the University of Alberta, where they spoke with Dave, Stan, and Lorne about their work on poxvirus vaccines and recombination, an enveloped picornavirus, antivirals against hepatitis B and C viruses, and supporting virology research in Alberta.

Links for this episode:  Li Ka Shing Institute of Virology Alberta Heritage Foundation for Medical Research Raised on a farm (YouTube) Vaccinia virus strains in Dryvax vaccine (J Virol) Vaccinia DNA polymerase and recombination (J Virol) Picornavirus hijacks cell membrane (Nature)

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242. TWiV 234: Live in Denver
http://www.twiv.tv/2013/05/26/... download (audio/mpeg, 55.58Mb)

Description:

Hosts: Vincent Racaniello and Kathy Spindler

Guests: Nels Elde and Tom Shenk

Vincent and Kathy recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Nels and Tom about their work on the evolution of virus-host conflict and how viruses influence the cell metabolome.

Links for this episode:  cross-species view on viruses (Curr Op Virol) Pox has got a squeeze box (TWiV 198) Saturated fatty acids needed for CMV (PLoS Path) CMV and HSV metabolomes differ (PLoS Path) Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



243. TWiV 233: We're surrounded
http://www.twiv.tv/2013/05/19/... download (audio/mpeg, 67.80Mb)

Description:

Hosts: Vincent RacanielloRich ConditAlan Dove, and Kathy Spindler

Vincent, Rich, Alan and Kathy review aerosol transmission studies of influenza H1N1 x H5N1 reassortants, H7N9 infections in China, and the MERS coronavirus.

Links for this episode: Aerosol transmission of H1N1 x H5N1 reassortants (Science) It's good science (virology blog) Viral engineering dangers (Nature) Colorblind web page filter Influenza H7N9 update (ProMedMail) Influenza H7N9 risk assessment (WHO, pdf) Influenza H7N9 confirmed cases (WHO) New coronavirus gets a new name (ScienceInsider) Novel coronavirus infection update (WHO) Coronavirus infections (WHO) Letters read on TWiV 233 Weekly Science Picks

Alan - Space Oddity (YouTube)
Rich - Walk through giant colon
Vincent -  Transport proteins
Kathy - Vomiting Larry (YouTube)

Listener Pick of the Week

Tom - US patent system is broken (DailyTech)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



244. TWiV 232: Gophers go viral
http://www.twiv.tv/2013/05/12/... download (audio/mpeg, 57.62Mb)

Description:

Hosts: Vincent RacanielloRoberto CattaneoReuben HarrisLou Mansky, and Leslie Schiff

Vincent meets up with Roberto, Reuben, Lou, and Leslie at the University of Minnesota to talk about their work on HIV-1, APOBEC proteins, measles virus, and teaching virology to undergraduates.

Links for this episode:  University of Minnesota virology timeline Revisiting HIV-1 lethal mutagenesis (Trends Micro) Exploiting HIV-1 drug repositioning (J Virol) 5-azaC induces HIV-1 lethal mutagenesis (J Virol) HIV-1 fitness and mutation rate (J Mol Biol) APOBEC3 mutagenesis in breast cancer (Nature) Restriction factors of HIV (J Biol Chem) Nectin-4 is epithelial measles receptor (Nature) Photographs of this episode: Click here Video of this episode - YouTube

 Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



245. TWiV 231: Hepaciviruses and pegiviruses in bats and rodents
http://www.twiv.tv/2013/05/05/... download (audio/mpeg, 52.49Mb)

Description:


Hosts: Vincent RacanielloAmit KapoorLan Quan, and Ian Lipkin

Vincent meets up with Amit, Lan, and Ian to discuss their discovery of hepaciviruses and pegiviruses in bats and rodents.

Links for this episode:  Canine hepacivirus (TWiV 137) Rodent homologs of hepaciviruses and pegiviruses (mBio) Bats are a reservoir of hepaciviruses and pegiviruses (PNAS)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



246. TWiV 230: Gene goes to Washington, flu chickens out
http://www.twiv.tv/2013/04/28/... download (audio/mpeg, 69.24Mb)

Description:

Hosts: Vincent RacanielloRich ConditAlan Dove, and Kathy Spindler

Vincent, Rich, Alan and Kathy review H7N9 infections in China, the debate over patenting genes, and receptor-binding by ferret-transmissible avian H5 influenza virus.

Links for this episode: Francois Jacob dies (The Loom)
WHO updates on H7N9 H7N9 is unusually dangerous (ScienceInsider) H7N9 case imported into Taiwan No H7N9 in poultry farms (Xinhua) Supreme Court considers gene patents (TheScientistNature) Patent my jeans, not my genes (Michael Wosnick) Receptor binding by ferret transmissible H5 virus (Nature) Microscale thermophoresis and bio-layer interferometry (Wikipedia) Letters read on TWiV 230 Weekly Science Picks

Alan - World Science Festival
Rich - 3 years of the sun in 3 minutes
Vincent -  The Origin of AIDS by Jacques Pepin
Kathy - Wringing out a wet washcloth in space (YouTube)

Listener Pick of the Week

Mark - Will it blend? (iPhone app)
Marianne - Enjoy your Cells

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



247. TWiV 229: Partly cloudy with a high of H7N9
http://www.twiv.tv/2013/04/21/... download (audio/mpeg, 65.63Mb)

Description:

Hosts: Vincent RacanielloRich ConditDickson Despommier, and Alan Dove

Vincent, Rich, Dickson, and Alan review the current status of human infections with avian influenza H7N9 virus.

Links for this episode: Hilary Koprowski, 96 (NY Times) Koprowski, Kessin, Racaniello photo Listen to the Music by Roger Vaughan Influenza ocular infections (onetwo) H7N9 global concerns (NEJM) Human infection with H7N9 (NEJM) WHO Global Alert and Response, H7N9 Avian influenza A(H7N9) virus (WHO) Novel H7N9 reassortant, implications for Europe (Eurosurveill) Genetic analysis of H7N9 (Eurosurveill) H7N9 compared with H7N7 outbreaks (Eurosurveill) Image credit: Eurosurveillance Letters read on TWiV 229 Weekly Science Picks

Alan - Nature PastCast
Rich - How dengue does it
Vincent -  Squeaky Squeegee Art by Deb Sklut
Dickson - Agritecture

Listener Pick of the Week

Mike - Chemistry in its element: Elements and Compounds

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



248. TWiV 228: Cal Bears go viral
http://www.twiv.tv/2013/04/14/... download (audio/mpeg, 46.88Mb)

Description:

Hosts: Vincent RacanielloBritt Glausinger, and Eva Harris

Vincent visits the University of California at Berkeley and speaks with Britt Glaunsinger and Eva Harris about their work on Kaposi's sarcoma associated herpesvirus and dengue virus.

Thanks to the Microbiology Graduate Students for hosting me at their annual symposium, and especially to Emma, Lisa, and Zoe for their wonderful hospitality during my stay.

Links for this episode: RNA element in IL-6 confers SOX resistance (J Virol) Dual uORFs regulate herpesviral translation (PLoS Path) Common viral strategy for RNA degradation (J Virol) KSHV SOX and Xrn1 together degrade host mRNAs (PLoS Path) Dengue treatment with Fc null antibodies (PLoS Path) Early clinical features of dengue in Nicaraguan children (PLoS Negl Trop Dis) Intrahuman dengue virus diversity (J Virol) Dynamics of dengue disease severity (Sci Transl Med)

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249. TWiV 227: Lacks security and bad poultry
http://www.twiv.tv/2013/04/07/... download (audio/mpeg, 65.33Mb)

Description:

Hosts: Vincent RacanielloRich ConditDickson DespommierAlan Dove, and Kathy Spindler

The complete TWiV team reviews the controversial publication of the HeLa cell genome, a missing vial of Guanarito virus in a BSL-4 facility, and human infections with avian influenza H7N9 virus.

Links for this episode: Containment plan for poliovirus (pdf, WHO) Post-eradication of polio Ocular tropism of respiratory viruses (MMBR) Rally for medical research HeLa genome sequence withdrawn (ScienceInsider) Immortal life sequel (Rebecca Skloot) HeLa genome sequence published, withdrawn (virology blog) Vial of Guanarito virus missing (ABC news) Human H7N9 infections (ProMedMail) WHO H7N9 updates China escalates H7N9 response (NY Times) Brian Kimble on H7N9 Compatibility of H9N2 and H1N1 genes (PNAS) Letters read on TWiV 227 Weekly Science Picks

Kathy - NIAID YouTube videos
Alan - Lego insects
Rich - How to see the world in a grain of sand
Vincent -  Vaccines, viruses, and the anti-vax movement
Dickson - Edinburgh Science Festival

Listener Pick of the Week

Stephen - Nature iOS app
Mehul - Voices for vaccines

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



250. TWiV 226: Taking the viral A train with Terry Dermody
http://www.twiv.tv/2013/03/31/... download (audio/mpeg, 63.93Mb)

Description:

Hosts: Vincent RacanielloDickson Despommier, and Terry Dermody

Vincent and Dickson speak with Terry Dermody about his career in medicine and virology.

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



251. TWiV 225: Transcripts from the inbox
http://www.twiv.tv/2013/03/24/... download (audio/mpeg, 69.52Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

Vincent, Rich, and Kathy read listener comments and questions on viral oncotherapy, science communication, a functional HIV cure in an infant, and much more.

Links for this episode: Plant viruses alter insect behavior (Sci Rep) Circovirus in Shanghai Letters read on TWiV 225 Weekly Science Picks

Kathy - Case stories about CoV-EMC (onetwo)
Rich - The Self-Illusion by Bruce Hood
Vincent - Moving Targets

Listener Pick of the Week

Liam - eLIFE and Rubriq
Steve - Plant virus ecology (mp3)
Neil - World Immunization Week

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv



252. TWiV 224: A wide receiver and a natural defense
http://www.twiv.tv/2013/03/17/... download (audio/mpeg, 65.31Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

Vincent, Alan, Kathy, and Dickson discuss identification of a cell receptor for the coronavirus-EMC, and the role of interferon-epsilon in protecting the female reproductive tract.

Links for this episode: Dipeptidyl peptidase 4 is CoV-EMC receptor (Nature) Receptor for new coronavirus (Nature) Broad reception for coronavirus (Nature) SARS 10th anniversary (Science) Interferon-epsilon protects female reproductive tract (Science) Families fighting flu (YouTube) Monitoring infections with online data (TWiM 41) Natalie Portman was a scientist (NY Times) Letters read on TWiV 223 Weekly Science Picks

Kathy - 2013 Intel Science Talent Search awards
Alan - Krebs Cycle Rap (CDC)
Vincent -  Jetpens (favorite one and two)
ickson - Rabies death in organ recipients (CDC)

Listener Pick of the Week

Justin - The DNA Store
Jim - Massive Open Online Classrooms
Chris - Feedly

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253. TWiV 223: EEEV and the serpent
http://www.twiv.tv/2013/03/10/... download (audio/mpeg, 61.28Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

Vincent, Alan, and Kathy discuss new influenza virus NA inhibitors, detection of EEEV antibody and RNA in snakes, and replication of the coronavirus EMC in human airway epithelial cells.

Links for this episode: International Women's Day 2013 Condit Dam, 6 weeks later (Vimeo) Influenza HA assay Covalent influenza NA inhibitors (ScienceExpress) Defective influenza HA mutants (Virology) New flu drug (BBCe! Science) EEEV antibody, RNA in snakes (Am J Trop Med Hyg) EEEV (CDC) Zoonotic potential of CoV-EMC (mBio) CoV-EMC update (ProMedMailCDC) CoV-EMC travel update (CDC) Letters read on TWiV 223 Weekly Science Picks

Kathy - Finkbeiner test and Women in Science
Alan - New flu vaccine efficacy study (CDC)
Vincent -  Threading the NEIDL video

Listener Pick of the Week

Steve - Prof. Joan Steitz on viral RNA
Ed - Archiving history of molecular biology: Press releasevideo, CSHL archives and videos

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254. TWiV 222: Jumpin' Jack Flash, it's a GAS GAS GAS
http://www.twiv.tv/2013/03/03/... download (audio/mpeg, 66.68Mb)

Description:

Hosts: Vincent RacanielloRich ConditDickson DespommierAlan Dove, and Kathy Spindler

The complete TWiV team discusses the amazing finding that cyclic GMP-AMP synthase is a cytosolic innate immune DNA sensor.

Links for this episode: Zhijian J. Chen (Wikipedia) Sensing the dark side of DNA (Science) cGAMP is an endogenous second messenger (Science) cGAMP synthase is a DNA sensor (Science) Pore-forming toxin (Wikipedia) Letters read on TWiV 222 Weekly Science Picks

Kathy - Graphene batteries
Alan - How do we get cures? (YouTube)
Rich - Explosive breach of Condit Dam (Vimeo)
Vincent -  10 things you can do to support open access (Tree of Life)

Listener Pick of the Week

Mark - The real story of Stuxnet
John - D-connector virus

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255. TWiV 221: Bunya there, done that
http://www.twiv.tv/2013/02/24/... download (audio/mpeg, 62.76Mb)

Description:

Hosts: Vincent RacanielloDickson Despommier, and Kathy Spindler

Vincent, Dickson, and Kathy review two emerging bunyaviruses, SFTSV and SBV.

Links for this episode: Human transmission of SFTSV (JID) SFTSV serosurvey (EID) SFTSV on TWiV 147 SFTSV in Japan (ProMedMail) SFTSV mouse model (PNAS) SBV infectious DNA and mouse model (PLoS Path) SBV in Sweden (ProMedMail) Letters read on TWiV 221 Weekly Science Picks

Kathy - Winners, 2012 Science & Engineering Visualization Challenge
Vincent -  The Operator and Dr. Oz's Problem

Listener Pick of the Week

Shane - OpenPCR
John - Python

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256. TWiV 220: Flu watches the clock while T7 gets a CAT scan
http://www.twiv.tv/2013/02/17/... download (audio/mpeg, 65.69Mb)

Description:

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler

Vincent, Rich, Alan, and Kathy discuss regulation of influenza virus replication by splicing, and the bacteriophage T7 random walk.

Links for this episode: Influenza splicing regulates infection (Cell Reports) Reporting on flu splicing from NPRBBCNBC Splicing of influenza RNA 8 (jpg) Bacteriophage T7 remodeling during infection (Science) Cryo-ET of intact cells (Trends Cell Biol) T7: The Movie (YouTube) Cry0-EM vs Cryo-ET (Wikipedia) Virus caught in the act (e! Science News) Letters read on TWiV 220 Weekly Science Picks

Kathy - Journal of Virology Image Gallery
Rich - Phage T7 Genetics and Physiology and slab gels
Alan - PeerJ (press release)
Vincent -  Virologia en Español

Listener Pick of the Week

Dave - Thingiverse pathogens and proteins 

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257. TWiV 219: Fauci pharmacy
http://www.twiv.tv/2013/02/10/... download (audio/mpeg, 43.79Mb)

Description:

Hosts: Vincent RacanielloRich Condit, and Anthony S. Fauci

Vincent and Rich meet up with Anthony S. Fauci, MD, Director of the National Institute of Allergy and Infectious Diseases.

Links for this episode: Fauci history (J Clin Inves)  Fauci Pharmacy Anthony Fauci (Wikipedia) Anthony Fauci: Unfinished business (Lens)

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258. TWiV 218: Monkeys turning valves and pushing buttons
http://www.twiv.tv/2013/02/03/... download (audio/mpeg, 61.44Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Welkin Johnson

Vincent, Alan, and Welkin discuss how endogenous retroviruses in mice are held in check by the immune response.

Links for this episode:  Kuan-Teh Jeang, 54
Resurrection of ERVs (Nature) Toll-like receptors control ERVs (Immunity) Retroviral danger from within (Immunity) Ancient viruses wreak havoc (The Scientist) Letters read on TWiV 218 Weekly Science Picks

Welkin - Viruses: Essential Agents of Life (review at STC)
Alan - Infinity Imagined
Vincent - Spaceship built for son

Listener Pick of the Week

Amanda - Written? Kitten!
Kevin - Protein synthesis: An epic (YouTube)
Daria - The Baltimore Scheme

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259. TWiV 217: I just flu in and my arms are shot
http://www.twiv.tv/2013/01/27/... download (audio/mpeg, 65.35Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Dickson Despommier

Vincent, Alan, Rich, and Dickson review influenza vaccines.

Links for this episode:  FDA licensed flu vaccines Seasonal influenza vaccine distributed How flu vaccine strains are selected (onetwo) WHO report on flu vaccine strain selection (pdf) Derek Smith on antigenic mapping Salk's 1945 influenza vaccine TIV preparation: FluzoneAgrifluFluvirinFluarixFlulavalAfluria (pdfs) LAIV preparation (pdf) Efficacy of flu vaccine 2012-13 (MMWRvirology blog) Meta-analysis of flu vaccine efficacy (Lancet) Two new flu vaccines FDA approved Flublok Flublok clinical trial Pandemrix and narcolepsy (YahooPLoS OnePLoS One) CIDRAP analysis of flu vaccines Letters read on TWiV 217 Weekly Science Picks

Rich - Repoopulate (original article), Robogut (new clinical trial)
Alan - WTF, Evolution?
Dickson - The Beauty and Benefits of Science
Vincent - Supercomputing modeling of poliovirus

Listener Pick of the Week

Bjorn, Marshall, Meaghan - Glass sculptures of Luke Jerram

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260. TWiV 216: Processing VIRALGUUAACACCAGRNA
http://www.twiv.tv/2013/01/20/... download (audio/mpeg, 63.82Mb)

Description:

Hosts: Vincent RacanielloAlan DoveRich Condit, and Kathy Spindler

Vincent, Alan, Rich, and Kathy resume the virology 101 series with a discussion of RNA capping, splicing, and export.

Links for this episode: Slides for this episode (pdf) Spliced Ad 2 late mRNAs (Cell) An amazing sequence arrangement (Cell) Adenovirus late mRNA undecanucleotide (Cell) Aaron Shatkin, 72 (virology blog) Schrödinger's cat (Wikipedia) Letters read on TWiV 216 Weekly Science Picks

Rich - Linus Pauling's explanation of science (YouTube)
Alan - Underwater experiments
Kathy - I'm a virus (YouTube)
Vincent - Stem cells (Bizarro Comics)

Listener Pick of the Week

Tom - The President's Analyst
D
anielle - Overly honest methods (HuffPost and ASBMB Today)

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261. TWiV 215: Illuminating rabies and unwrapping a SARI
http://www.twiv.tv/2013/01/13/... download (audio/mpeg, 63.41Mb)

Description:

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler

Vincent, Alan, and Kathy review the finding that rabies virus infection alters but does not kill neurons, and provide an update on the novel coronavirus in the Middle East.

Links for this episode: Neuronal survival after rabies virus infection (PLoS Path) Clusters of coronavirus cases (Nature) ProMedMail on novel coronavirus Novel coronavirus outbreak news (Int J Inf Dis) Genomic characterization of novel coronavirus (mBio) Broad cell tropism of novel coronavirus (mBio) Are viruses alive? (poll at virology blog) Antibodies taken up by endocytosis (PNAS) Antibody eliminates alphaviruses from neurons (Science) Image: Virus in the garden by Helen Hache Letters read on TWiV 215 Weekly Science Picks

Alan - I'm a Scientist - The Film
Kathy - Humorous units of measurement (Wikipedia)
Vincent - Open access must enable open use (Nature)

Listener Pick of the Week

Tarwin - Plague Inc.

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262. TWiV 214: This is your brain on polyomavirus
http://www.twiv.tv/2013/01/06/... download (audio/mpeg, 53.52Mb)

Description:

Hosts: Vincent RacanielloRich Alan Dove, and Kathy Spindler

Vincent, Alan, and Kathy discuss how coagulation factor X binding to adenovirus activates the innate immune system, and a novel polyomavirus associated with