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| Podcast title | Seminars from Cure4Kids.org
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| http://www.cure4kids.org/podca... | ||
| Description | This podcast is brought to you by St. Jude Children's Research Hospital. It includes selected seminars that are produced by the Cure4Kids educational program which provides continuing education and online collaboration tools to pediatric oncologis | |
| Updated | Sat, 20 Mar 2010 23:54:16 -0500 | |
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| Category | Science & Medicine Education Health |
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1. Acute Lymphoblastic Leukemia: Recent Advances http://feedproxy.google.com/~r... download (video/x-m4v, 115.68Mb) Description: Remarkable advances in the treatment of childhood acute lymphoblastic leukemia (ALL) are due to the effectiveness of risk-directed therapy developed through well-designed clinical trials. Ching-Hon Pui, MD, presents the development, implementation and outcomes of the St. Jude Total XV. Total XV adopts the effective treatment components of successful clinical trials, individualizes therapy by using risk-assessment strategies and limits the use of treatment modalities known to have significant late effects. Dario Campana, MD, PhD, discusses the significance of measuring minimal residual disease to assess treatment response and to further gauge the need for intensification of therapy. Campana also presents cell therapy for leukemia, using redirected natural killer cells. James Downing, PhD, discusses the remarkable advances in defining molecular abnormalities involved in leukomogenesis. Genomic-wide analysis can identify cooperating oncogenic lesions that potentially contributes to ALL pathogenesis. With new knowledge and understanding of the biological features of leukemic cells, host genetics and the amount of residual disease, the cure rate for childhood acute lymphoblastic leukemia should continue to improve.
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2. Postoperative Mutism in Children with Infratentorial Tumors http://feedproxy.google.com/~r... download (video/x-m4v, 80.34Mb) Description: Clinicians have often recognized the occurrence of mutism after resection of posterior fossa tumors in pediatric patients; however, the pathophysiology of this occurrence remains unclear. Commonly referred to as cerebellar mutism syndrome, this unique postoperative event typically arises one-to-two days after tumor resection. The syndrome includes diminished speech progressing to mutism, emotional lability, hypotonia and ataxia. Brannon Morris, MD, reviews pediatric brain tumors and posterior fossa syndrome. He presents the case of a 4-year-old patient who develops mutism two days after undergoing a total gross resection of a posterior fossa mass. Allison Jacobs-Levine discusses the role of occupational and physical therapy in managing mutism in children. Nicholas Phillips presents a study that uses functional imaging to evaluate the cortical language centers of a patient with transient mutism immediately after surgery. |
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3. Influenza from Genome to Vaccine http://feedproxy.google.com/~r... download (video/x-m4v, 99.72Mb) Description: This seminar is divided into four sections, where Robert Webster, PhD begins the first part of the presentation with the historical aspects of the influenza A virus. He describes how the virus mutates through several mechanisms and how it is transmitted from various species to affect humans. The avian birds, in particular the mallard ducks, are the prominent species spreading the virus worldwide. Influenza A is an RNA virus, and mutations are prominent because there is no proofreading mechanism during replication. Clayton Naeve, PhD, then describes the Influenza Genome Project currently taking place at St. Jude Children’s Research Hospital. Setting up a sequencing database of the virus in several species has been successful and now genotype-phenotype correlation studies are taking place along with bioinformatic analyses of the avian and human influenza viruses. Jie Zheng, PhD, describes the specific protein domains of the virus and how the protein-protein interactions were found through NMR and chemical shift perturbation studies. This information is critical for development of effective vaccines. Richard Webby, PhD, concludes the seminar by describing the current need and status of designing vaccines based on the protein sequencing data (changes in the hemagglutanin and neuraminidase sequences). Vaccines will be made now and in the future since the virus mutates at such a rapid pace and has the potential for such high mortality if widespread infection occurs in humans. |
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